Výsledky vyhledávání - "Jeong Eun Jang"

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Chimeric crRNAs with 19 DNA residues in the guide region show the retained DNA cleavage activity of Cas9 with potential to improve the specificity

Autor: Jinsu An, Dae-Ro Ahn, Hee Jae Lee, Duhee Bang, Jong Seong Ahn, Cherlhyun Jeong, Jihyun Park, Hak Suk Chung, Seong Jae Kang, Hyo Young Kim, Yongmoon Jeon, Jeong Eun Jang

Publikováno v: Chemical Communications. 55:3552-3555

We demonstrated that 19 out of 20 RNA residues in the guide region of crRNA can be replaced with DNA residues with high GC-contents. The cellular activity of the chimeric crRNAs to disrupt the target gene was comparable to that of the native crRNA.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d61a5e0481fe4c4847dfc6f9a01075
https://doi.org/10.1039/c8cc08468h

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A brain tumor-homing tetra-peptide delivers a nano-therapeutic for more effective treatment of a mouse model of glioblastoma

Autor: Eugene Huh, Dokyoung Kim, Seung Geun Yeo, Jeong Eun Jang, Seong Jae Kang, Rae Hyung Kang, Hyo Young Kim, Michael J. Sailor, Dae-Ro Ahn, Myung Sook Oh, Jae Seung Kang

Publikováno v: Nanoscale horizons. 5(8)

Organ-specific cell-penetrating peptides (CPPs) are a class of molecules that can be highly effective at delivering therapeutic cargoes, and they are currently of great interest in cancer treatment strategies. Herein, we describe a new CPP (amino aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197f741734a0e93f3fada9184ec873ff
https://pubmed.ncbi.nlm.nih.gov/32510090

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Dimeric Human β-Defensin 3 as a Universal Platform for Intracellular Delivery of Nucleic Acid Cargos

Autor: Dae-Ro Ahn, Jeong-Eun Jang, Hyo Young Kim

Publikováno v: ACS Applied Bio Materials. 1:100-109

Functional nucleic acids including siRNA, mRNA, and plasmid DNA are promising bioactive molecules to regulate cellular functions uncontrollable by conventional small molecule regulators. To realize successful cellular applications of these nucleic ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::433ead02579ee5e12f1bb6d212cd4bd7
https://doi.org/10.1021/acsabm.8b00024

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Lectin, Galactoside-Binding Soluble 3 Binding Protein Promotes 17-N-Allylamino-17-demethoxygeldanamycin Resistance through PI3K/Akt Pathway in Lung Cancer Cell Line

Autor: Seung Hyun Oh, Ju-Hee Kang, Hyoung-Chin Kim, Je Kyung Seong, Sang-Jin Lee, Yeo Sung Yoon, Jong Kyu Woo, Jeong-Eun Jang

Publikováno v: Molecular Cancer Therapeutics. 16:1355-1365

Heat shock protein 90 (HSP90) stabilizing oncoproteins has been an attractive target in cancer therapy. 17-N-Allylamino-17-demethoxygeldanamycin (17-AAG), an HSP90 inhibitor, was tested in phase II/III clinical trials, but due to lack of efficacy, cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b99c50009b416386261096445dc9156
https://doi.org/10.1158/1535-7163.mct-16-0574

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Wasabia japonica is a potential functional food to prevent colitis via inhibiting the NF-κB signaling pathway

Autor: Prakash Ramalingam, Seung-Ho Choi, Seung Hyun Oh, Ju-Hee Kang, Jeong-Eun Jang, Young Tag Ko, Sun Yeou Kim

Publikováno v: Food & Function. 8:2865-2874

Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are prevalent and debilitating health problems worldwide. Many types of drugs are used to treat IBDs, but they exhibit adverse effects such as vomiting, n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0160ad8ac7c93c03518424ec96c122
https://doi.org/10.1039/c7fo00576h

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