Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jeon, Yoon T."'
Autor:
Arunachalam Arumugam, Dietmar A. Seiffert, Arvind Mathur, Joanna J. Zheng, Ruth R. Wexler, Jeon Yoon T, Premsai Rai Neithnadka, Earl J. Crain, Paul J. Gilligan, Patrick Y.S. Lam, Yiming Wu, Mahammed Kaspady, Pancras C. Wong, Tianan Fang, Silvi A. Chacko, William R. Ewing, Pabbisetty Kumar Balashanmuga, Zhen Lou, Steven Sheriff, Joseph M. Luettgen, Joseph E. Myers, Wu Yang, Karen A. Rossi, Richard Rampulla, James R. Corte, Amy Lai, Charles G. Clark, Jeffrey M. Bozarth, Yufeng Wang, Sivashankaran Raju
Publikováno v:
Journal of Medicinal Chemistry. 63:7226-7242
Oral factor XIa (FXIa) inhibitors may provide a promising new antithrombotic therapy with an improved benefit to bleeding risk profile over existing antithrombotic agents. Herein, we report application of a previously disclosed cyclic carbamate P1 li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ab508367fcb2f182343eb9240eeb1b
https://doi.org/10.1021/acs.jmedchem.0c00464
https://doi.org/10.1021/acs.jmedchem.0c00464
Autor:
Timothy W. Harper, Danshi Li, Huabin Sun, Mei-Mann Hsueh, Alexander Kover, Paul Levesque, Heather Finlay, James A. Johnson, John Lloyd, Ruth R. Wexler, Mary Lee Conder, Ningning Xu, Jeon Yoon T
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3018-3022
Phenethylaminoheterocycles have been prepared and assayed for inhibition of the Kv1.5 potassium ion channel as a potential approach to the treatment of atrial fibrillation. A diverse set of heterocycles were identified as potent Kv1.5 inhibitors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fef5b55ecd47e4b988296865f4c6b5
https://doi.org/10.1016/j.bmcl.2014.05.035
https://doi.org/10.1016/j.bmcl.2014.05.035
Autor:
Qian Xiang, Dietmar A. Seiffert, Wu Yang, Tianan Fang, Joseph E. Myers, Joanne M. Smallheer, Patrick Y.S. Lam, Jeon Yoon T, Zhen Lou, Joanna Zheng, Joseph M. Luettgen, Jeffrey M. Bozarth, Steven Sheriff, Yufeng Wang, William R. Ewing, Zilun Hu, Indawati De Lucca, Donald J. P. Pinto, Michael J. Orwat, James R. Corte, Charles G. Clark, Karen A. Rossi, Alan R. Rendina, Timothy W. Harper, Ruth R. Wexler, David S. Nirschl, Baomin Xin, Yiming Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:126604
This manuscript describes the discovery of a series of macrocyclic inhibitors of FXIa with oral bioavailability. Assisted by structure based drug design and ligand bound X-ray crystal structures, the group linking the P1 moiety to the macrocyclic cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2efb9337fd87b82e6dbe509f35d0ce6
https://doi.org/10.1016/j.bmcl.2019.08.008
https://doi.org/10.1016/j.bmcl.2019.08.008
Autor:
Gary J. Grover, Narayanan Hariharan, Wei Wang, Dennis Farrelly, Jeon Yoon T, Fucheng Qu, Rajasree Golla, Zhengping Ma, Lisa Moore, Arthur M. Doweyko, Gamini Chandrasena, Pratik Devasthale, Denis E. Ryono, Lin Cheng, Chen Sean, Peter T. W. Cheng, Wei Sun, Ramakrishna Seethala, Paul G. Sleph, Hao Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2312-2316
A novel series of potent dual agonists of PPARα and PPARγ, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure–activity relationships of this series of dual PPARα/γ agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd833e6d647f89a09342d5bb9c6b46a1
https://doi.org/10.1016/j.bmcl.2007.01.060
https://doi.org/10.1016/j.bmcl.2007.01.060
Autor:
Narayanan Hariharan, Kasim A. Mookhtiar, Liqun Gu, Jimmy Ren, Chen Sean, Ramakrishna Seethala, Michael Cap, Lori Kunselman, Min Zhou, Peter T. W. Cheng, William Fenderson, Chunning Shao, Cuixia Chu, Scott A. Biller, Hao Zhang, Fucheng Qu, Pratik Devasthale, Dennis Farrelly, Jeon Yoon T, Randolph P. Ponticiello, John R. Wetterau, Wei Wang, Wen-Pin Yang, Thomas Harrity, Aaron Tieman, Denis E. Ryono, Richard E. Gregg
Publikováno v:
Diabetes. 55:240-248
Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor (PPAR) activator, was investigated for its antidiabetic properties and its effects on metabolic abnormalities in genetically obese diabetic db/db mice. In db/db mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4d94ba455d51e1e5f39b4a1484a6b08
https://doi.org/10.2337/diabetes.55.01.06.db05-0648
https://doi.org/10.2337/diabetes.55.01.06.db05-0648
Autor:
Jeon, Yoon T., Yang, Wu, Qiao, Jennifer X., Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C., Wang, Yufeng, Liu, Yajun, Clark, Charles G., Wong, Henry S., Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A., Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S., Schumacher, William A., Bostwick, Jeffrey S., Stewart, Anne B., Price, Laura A., Hua, Ji, Li, Danshi, Levesque, Paul C., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 March 2014 24(5):1294-1298
Autor:
Robert P. Rehfuss, Paul Levesque, Juliang Zhu, Arvind Mathur, Dietmar A. Seiffert, Bang-Chi Chen, Rejean Ruel, Laura Price, Yufeng Wang, Mary F. Malley, Xue-Qing Chen, Wu Yang, Ji Hua, Tammy C. Wang, William A. Schumacher, Yajun Liu, Dauh-Rurng Wu, Silvi A. Chacko, Jeffrey S. Bostwick, Charles G. Clark, Danshi Li, Patrick Y.S. Lam, Henry S. Wong, Anne B. Stewart, Dawn Sun, Ruth R. Wexler, Hong Shen, Sheldon Hiebert, Christine Huang, Ling Li, Jeon Yoon T, Carl Thibeault, Jennifer X. Qiao
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(5)
Spiropiperidine indoline-substituted diaryl ureas had been identified as antagonists of the P2Y1 receptor. Enhancements in potency were realized through the introduction of a 7-hydroxyl substitution on the spiropiperidinylindoline chemotype. SAR stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87ed0cd8e9411cf0132670a06c19e56
https://pubmed.ncbi.nlm.nih.gov/24513044
https://pubmed.ncbi.nlm.nih.gov/24513044
Autor:
Denis E. Ryono, Chen Sean, Pratik Devasthale, Shu Y Chang, John R. Wetterau, W. Griffith Humphreys, Gary J. Grover, Dennis Farrelly, Jeon Yoon T, Fucheng Qu, Ramakrishna Seethala, Narayanan Hariharan, Wei Wang, Zhengping Ma, Scott A. Biller, Rajasree Golla, Lisa Moore, Arthur M. Doweyko, Michael Cap, Fred Selan, Jimmy Ren, Paul G. Sleph, Hao Zhang, Aaron Tieman, Vito G. Sasseville, Thomas Harrity, Gamini Chandrasena, Chunning Shao, Peter T. W. Cheng, Lin Cheng, Wei Sun
Publikováno v:
Journal of Medicinal Chemistry. 48:2248-2250
Muraglitazar/BMS-298585 (2) has been identified as a non-thiazolidinedione PPAR alpha/gamma dual agonist that shows potent activity in vitro at human PPARalpha (EC(50) = 320 nM) and PPARgamma(EC(50) = 110 nM). Compound 2 shows excellent efficacy for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4290978295e11d6657e63d9f0bae7a68
https://doi.org/10.1021/jm0496436
https://doi.org/10.1021/jm0496436
Autor:
Chi Luo, Carlos Forray, Charles Gluchowski, Pierre J.-J. Vaysse, Jeon Yoon T, Theresa Branchek
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2255-2258
As a part of a program directed at the identification of subtype selective α2 agonists, a series of analogs of UK-14,304 (1) were synthesized. Binding affinities and functional efficacies were measured at cloned human α adrenergic receptors. A numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7314d97d90c88062498c168785d9b5b8
https://doi.org/10.1016/0960-894x(95)00391-6
https://doi.org/10.1016/0960-894x(95)00391-6
Autor:
Jeon, Yoon T.1, Yang, Wu1 wu.yang@bms.com, Qiao, Jennifer X.1 jennifer.qiao@bms.com, Li, Ling1, Ruel, Rejean1, Thibeault, Carl1, Hiebert, Sheldon1, Wang, Tammy C.1, Wang, Yufeng1, Liu, Yajun1, Clark, Charles G.1, Wong, Henry S.1, Zhu, Juliang1, Wu, Dauh-Rurng1, Sun, Dawn1, Chen, Bang-Chi1, Mathur, Arvind1, Chacko, Silvi A.2, Malley, Mary2, Chen, Xue-Qing2
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. Mar2014, Vol. 24 Issue 5, p1294-1298. 5p.