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MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation.

Autor: Pantier R; The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, The King's Buildings, Edinburgh, EH9 3BF, UK., Brown M; The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, The King's Buildings, Edinburgh, EH9 3BF, UK., Han S; The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, The King's Buildings, Edinburgh, EH9 3BF, UK., Paton K; The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, The King's Buildings, Edinburgh, EH9 3BF, UK., Meek S; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK., Montavon T; Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108, Freiburg, Germany., Shukeir N; Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108, Freiburg, Germany., McHugh T; The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, The King's Buildings, Edinburgh, EH9 3BF, UK., Kelly DA; The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, The King's Buildings, Edinburgh, EH9 3BF, UK., Hochepied T; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Libert C; Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Jenuwein T; Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108, Freiburg, Germany., Burdon T; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK., Bird A; The Wellcome Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Max Born Crescent, The King's Buildings, Edinburgh, EH9 3BF, UK. a.bird@ed.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 May 08; Vol. 15 (1), pp. 3880. Date of Electronic Publication: 2024 May 08.

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Akademický článek

Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis.

Autor: Djeghloul D; Epigenetic Memory Group, MRC London Institute of Medical Sciences, Imperial College London, London, UK. d.djeghloul@lms.mrc.ac.uk., Dimond A; Epigenetic Memory Group, MRC London Institute of Medical Sciences, Imperial College London, London, UK., Cheriyamkunnel S; Epigenetic Memory Group, MRC London Institute of Medical Sciences, Imperial College London, London, UK., Kramer H; Biological Mass Spectrometry and Proteomics Facility, MRC London Institute of Medical Sciences, Imperial College London, London, UK., Patel B; Flow Cytometry Facility, MRC London Institute of Medical Sciences, Imperial College London, London, UK., Brown K; Epigenetic Memory Group, MRC London Institute of Medical Sciences, Imperial College London, London, UK., Montoya A; Biological Mass Spectrometry and Proteomics Facility, MRC London Institute of Medical Sciences, Imperial College London, London, UK., Whilding C; Microscopy Facility, MRC London Institute of Medical Sciences, Imperial College London, London, UK., Wang YF; Bioinformatics, MRC London Institute of Medical Sciences, Imperial College London, London, UK., Futschik ME; Bioinformatics, MRC London Institute of Medical Sciences, Imperial College London, London, UK., Veland N; Epigenetic Memory Group, MRC London Institute of Medical Sciences, Imperial College London, London, UK., Montavon T; Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Jenuwein T; Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Merkenschlager M; Lymphocyte Development Group, MRC London Institute of Medical Sciences, Imperial College London, London, UK., Fisher AG; Epigenetic Memory Group, MRC London Institute of Medical Sciences, Imperial College London, London, UK. amanda.fisher@lms.mrc.ac.uk.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2023 Apr; Vol. 30 (4), pp. 489-501. Date of Electronic Publication: 2023 Mar 20.

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Additional file 3 of Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia

Autor: Onishi-Seebacher, M., Erikson, G., Sawitzki, Z., Ryan, D., Greve, G., Lübbert, M., Jenuwein, T.

Additional file 3: Figure S3: MA plots for distinct repeat element expression in M1, M2 and M4 AML patient samples (Uniklinik Freiburg). MA-plots (mean expression versus the log2 fold change) depicting changes in repeat expression in the CD34+ contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa4713c1019319236118540e107a3e4

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Additional file 10 of Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia

Autor: Onishi-Seebacher, M., Erikson, G., Sawitzki, Z., Ryan, D., Greve, G., Lübbert, M., Jenuwein, T.

Additional file 10: Figure S10. Correlation between recurring gene mutations and R/G ratios in TCGA AML patient samples. (A) Box plot showing the most frequent gene mutations (x axis) in the TCGA AML cohort (n=98), as they were identified using metad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c72c84008454e07bd08d4bfb676248e

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Additional file 7 of Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia

Autor: Onishi-Seebacher, M., Erikson, G., Sawitzki, Z., Ryan, D., Greve, G., Lübbert, M., Jenuwein, T.

Additional file 7: Figure S7. Coverage and distribution of repeat transcripts in Uniklinik Freiburg samples and in the Blueprint and TCGA data sets. (A) Fraction of all repeat transcripts (blue segment) versus the fraction of all protein coding trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2793414137290475a24e063a068512c3

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Additional file 6 of Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia

Autor: Onishi-Seebacher, M., Erikson, G., Sawitzki, Z., Ryan, D., Greve, G., Lübbert, M., Jenuwein, T.

Additional file 6: Figure S6: Inter-patient variation plots for expression of 12 LTR/ERV repeat subtypes in TCGA AML samples. Inter-patient variation plots display normalized read counts of distinct LTR/ERV repeat transcripts that are above the expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6185d83c5a4248bd593369a0ac737018

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Additional file 5 of Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia

Autor: Onishi-Seebacher, M., Erikson, G., Sawitzki, Z., Ryan, D., Greve, G., Lübbert, M., Jenuwein, T.

Additional file 5: Figure S5: Inter-patient variation plots for expression of 12 Satellite repeat subtypes in TCGA AML samples. Inter-patient variation plots display normalized read counts of distinct Satellite repeat transcripts that are above the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c664ad5ec005121a226c2f8005b7501

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Additional file 4 of Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia

Autor: Onishi-Seebacher, M., Erikson, G., Sawitzki, Z., Ryan, D., Greve, G., Lübbert, M., Jenuwein, T.

Additional file 4: Figure S4. Heatmaps for dysregulated repeat element expression in Uniklinik Freiburg and Blueprint AML samples. (A) Top 30 statistically significant (absolute value of log2FoldChange >1; adjusted p-value 1; adjusted p-value

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45baf20fc54a557d09dbe617db23de48

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Additional file 8 of Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia

Autor: Onishi-Seebacher, M., Erikson, G., Sawitzki, Z., Ryan, D., Greve, G., Lübbert, M., Jenuwein, T.

Additional file 8: Figure S8: Inter-patient variation plots for expression of repeat element subclasses in ‘low-repeat’, ‘mid-repeat’ and ‘high-repeat’ AML patient samples. Inter-patient variation plots display normalized read counts in e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bd10d34918b9f12cf2303960a00da2

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Akademický článek

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