Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jenson Verghese"'
Autor:
Eric Yu, Hari P. R. Mangunuru, Nakul S. Telang, Caleb J. Kong, Jenson Verghese, Stanley E. Gilliland III, Saeed Ahmad, Raymond N. Dominey, B. Frank Gupton
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 583-592 (2018)
Numerous synthetic methods for the continuous preparation of fine chemicals and active pharmaceutical ingredients (API’s) have been reported in recent years resulting in a dramatic improvement in process efficiencies. Herein we report a highly effi
Externí odkaz:
https://doaj.org/article/edaae01b8fa240dc90d1188373e91ee9
Autor:
Wolfgang Jud, Chase A. Salazar, Joseph Imbrogno, Jenson Verghese, Steven M. Guinness, Jean-Nicolas Desrosiers, C. Oliver Kappe, David Cantillo
Publikováno v:
Organic Process Research & Development. 26:1486-1495
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::221a714ae91ae32b6007cb29fd821852
https://doi.org/10.1021/acs.oprd.2c00064
https://doi.org/10.1021/acs.oprd.2c00064
Autor:
D. Tyler McQuade, Katherine Belecki, Caleb J. Kong, B. Frank Gupton, Julie B. Manley, Saeed Ahmad, Daniel Rivalti, Rudy Krack, Jesús Alcázar, Eric C. Yu, Jenson Verghese
Publikováno v:
Green Chemistry. 19:2986-2991
Access to affordable medications continues to be one of the most pressing issues for the treatment of disease in developing countries. For many drugs, synthesis of the active pharmaceutical ingredient (API) represents the most financially important a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1874817cc48e5f5e24dfd7771f2c29e0
https://doi.org/10.1039/c7gc00937b
https://doi.org/10.1039/c7gc00937b
Autor:
Keith C. Ellis, Lisa M. Oppegard, Hiroshi Hiasa, Lauren M. Seivert, Jenson Verghese, Thuy Nguyen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5874-5877
The increasing occurrence of drug-resistant bacterial infections in the clinic has created a need for new antibacterial agents. Natural products have historically been a rich source of both antibiotics and lead compounds for new antibacterial agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8227d23988bb215bf90e5803cf0017c1
https://doi.org/10.1016/j.bmcl.2013.08.094
https://doi.org/10.1016/j.bmcl.2013.08.094
Publikováno v:
Medicinal Chemistry Research. 21:624-633
We report both automated rigid and flexible ligand docking simulations performed on fifty peroxisome proliferator-activated receptor (PPAR-γ) agonists, namely, glitazones. The binding conformations and binding affinities of these agonists were obtai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::288d72138bc79f6589262f220e78f320
https://doi.org/10.1007/s00044-011-9548-x
https://doi.org/10.1007/s00044-011-9548-x
Strategies to inhibit kinases by targeting the substrate binding site offer many advantages, including naturally evolved selectivity filters, but normally suffer from poor potency. In this work we propose a strategy to design and prepare covalent sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4621ea84a0ee98b8373b8e915b883116
https://europepmc.org/articles/PMC4027749/
https://europepmc.org/articles/PMC4027749/
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
Designing non-saccharide functional mimics of heparin is a major challenge. In this work, a library of small, aromatic molecules based on the sulfated DHP scaffold was synthesized and screened against thrombin and factor Xa. The results reveal that (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4ea8909b49bcbd2a6105a64c33b45d
https://pubmed.ncbi.nlm.nih.gov/19540113
https://pubmed.ncbi.nlm.nih.gov/19540113