MYC activity at enhancers drives prognostic transcriptional programs through an epigenetic switch.

Autor: Jakobsen ST; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Jensen RAM; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Madsen MS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Ravnsborg T; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Vaagenso CS; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Siersbæk MS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Einarsson H; Department of Biology, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Andersson R; Department of Biology, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jensen ON; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Siersbæk R; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark. siersbaek@bmb.sdu.dk.

Publikováno v: Nature genetics [Nat Genet] 2024 Apr; Vol. 56 (4), pp. 663-674. Date of Electronic Publication: 2024 Mar 07.

An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors.

Autor: Garcia DA; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20893, USA; Department of Physics, University of Maryland, College Park, MD 20742, USA., Johnson TA; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20893, USA., Presman DM; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), CONICET-Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, C1428EGA Buenos Aires, Argentina., Fettweis G; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20893, USA., Wagh K; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20893, USA; Department of Physics, University of Maryland, College Park, MD 20742, USA., Rinaldi L; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20893, USA., Stavreva DA; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20893, USA., Paakinaho V; Institute of Biomedicine, University of Eastern Finland, Kuopio, P.O. Box 1627, 70211 Kuopio, Finland., Jensen RAM; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20893, USA; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Mandrup S; Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742, USA., Upadhyaya A; Department of Physics, University of Maryland, College Park, MD 20742, USA; Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742, USA. Electronic address: arpitau@umd.edu., Hager GL; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20893, USA. Electronic address: hagerg@exchange.nih.gov.

Publikováno v: Molecular cell [Mol Cell] 2021 Apr 01; Vol. 81 (7), pp. 1484-1498.e6. Date of Electronic Publication: 2021 Feb 08.