The GPI sidechain of Toxoplasma gondii inhibits parasite pathogenesis.

Autor: Alvarez JA; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, USA.; Quantitative and Systems Biology Graduate Program, University of California, Merced, California, USA., Gas-Pascual E; Department of Biochemistry and Molecular Biology, Center for Tropical and Emerging Global Diseases, and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA., Malhi S; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, USA., Sánchez-Arcila JC; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, USA., Njume FN; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, USA., van der Wel H; Department of Biochemistry and Molecular Biology, Center for Tropical and Emerging Global Diseases, and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA., Zhao Y; Department of Medicine and Center for Immunity and Inflammation, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA., García-López L; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, USA.; Quantitative and Systems Biology Graduate Program, University of California, Merced, California, USA., Ceron G; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, USA., Posada J; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, USA., Souza SP; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, USA.; Quantitative and Systems Biology Graduate Program, University of California, Merced, California, USA., Yap GS; Department of Medicine and Center for Immunity and Inflammation, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA., West CM; Department of Biochemistry and Molecular Biology, Center for Tropical and Emerging Global Diseases, and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA., Jensen KDC; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, USA.; Health Sciences Research Institute, University of California, Merced, California, USA.

Publikováno v: MBio [mBio] 2024 Oct 16; Vol. 15 (10), pp. e0052724. Date of Electronic Publication: 2024 Sep 20.

Variation in CD8 T cell IFNγ differentiation to strains of Toxoplasma gondii is characterized by small effect QTLs with contribution from ROP16.

Autor: Kongsomboonvech AK; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA, United States.; Quantitative Systems Biology Graduate Program, University of California, Merced, Merced, CA, United States., García-López L; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA, United States.; Quantitative Systems Biology Graduate Program, University of California, Merced, Merced, CA, United States., Njume F; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA, United States., Rodriguez F; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA, United States., Souza SP; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA, United States.; Quantitative Systems Biology Graduate Program, University of California, Merced, Merced, CA, United States., Rosenberg A; The Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, United States., Jensen KDC; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA, United States.; Health Sciences Research Institute, University of California, Merced, Merced, CA, United States.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 May 23; Vol. 13, pp. 1130965. Date of Electronic Publication: 2023 May 23 (Print Publication: 2023).

Genetic mapping reveals Nfkbid as a central regulator of humoral immunity to Toxoplasma gondii.

Autor: Souza SP; School of Natural Sciences, Department of Molecular and Cell Biology, University of California, Merced, Merced, California, United States of America.; Graduate Program in Quantitative and Systems Biology, University of California, Merced, Merced, California, United States of America., Splitt SD; School of Natural Sciences, Department of Molecular and Cell Biology, University of California, Merced, Merced, California, United States of America.; Graduate Program in Quantitative and Systems Biology, University of California, Merced, Merced, California, United States of America., Sànchez-Arcila JC; School of Natural Sciences, Department of Molecular and Cell Biology, University of California, Merced, Merced, California, United States of America., Alvarez JA; School of Natural Sciences, Department of Molecular and Cell Biology, University of California, Merced, Merced, California, United States of America.; Graduate Program in Quantitative and Systems Biology, University of California, Merced, Merced, California, United States of America., Wilson JN; School of Natural Sciences, Department of Molecular and Cell Biology, University of California, Merced, Merced, California, United States of America.; Graduate Program in Quantitative and Systems Biology, University of California, Merced, Merced, California, United States of America., Wizzard S; School of Natural Sciences, Department of Molecular and Cell Biology, University of California, Merced, Merced, California, United States of America., Luo Z; Center for Immunology & Infectious Diseases, and Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, California, United States of America., Baumgarth N; Center for Immunology & Infectious Diseases, and Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, California, United States of America., Jensen KDC; School of Natural Sciences, Department of Molecular and Cell Biology, University of California, Merced, Merced, California, United States of America.; Health Science Research Institute, University of California, Merced, Merced, California, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2021 Dec 06; Vol. 17 (12), pp. e1010081. Date of Electronic Publication: 2021 Dec 06 (Print Publication: 2021).

The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages

Autor: Hassan, MA, Butty, V, Jensen, KDC, Saeij, JPJ

Publikováno v: Hassan, MA; Butty, V; Jensen, KDC; & Saeij, JPJ. (2014). The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages. Genome Research, 24(3), 377-389. doi: 10.1101/gr.166033.113. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/0fm1626m

Alternative splicing and mRNA editing are known to contribute to transcriptome diversity. Although alternative splicing is pervasive and contributes to a variety of pathologies, including cancer, the genetic context for individual differences in isof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::71407d11c1cad221adf223b232d1fd72
http://www.escholarship.org/uc/item/0fm1626m

T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice.

Autor: Mullins GN; Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, CA, 95343, USA.; Health Sciences Research Institute, University of California Merced, Merced, CA, 95343, USA., Valentine KM; Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, CA, 95343, USA.; Health Sciences Research Institute, University of California Merced, Merced, CA, 95343, USA., Al-Kuhlani M; Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA., Davini D; Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA., Jensen KDC; Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, CA, 95343, USA.; Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA.; Health Sciences Research Institute, University of California Merced, Merced, CA, 95343, USA., Hoyer KK; Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, CA, 95343, USA. khoyer2@ucmerced.edu.; Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA. khoyer2@ucmerced.edu.; Health Sciences Research Institute, University of California Merced, Merced, CA, 95343, USA. khoyer2@ucmerced.edu.

Publikováno v: Scientific reports [Sci Rep] 2020 Dec 15; Vol. 10 (1), pp. 21994. Date of Electronic Publication: 2020 Dec 15.