Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target

Autor: Waters, Nigel J., Daigle, Scott R., Rehlaender, Bruce N., Basavapathruni, Aravind, Campbell, Carly T., Jensen, Tyler B., Truitt, Brett F., Olhava, Edward J., Pollock, Roy M., Stickland, Kim A., Dovletoglou, Angelos

Publikováno v: In Journal of Controlled Release 28 December 2015 220 Part B:758-765

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Tracing the evolution of single-cell cancer 3D genomes: an atlas for cancer gene discovery.

Autor: Liu M; Department of Genetics, Yale School of Medicine, Yale University; New Haven, CT 06510, USA., Jin S; Department of Genetics, Yale School of Medicine, Yale University; New Haven, CT 06510, USA., Agabiti SS; Department of Genetics, Yale School of Medicine, Yale University; New Haven, CT 06510, USA.; Yale Cancer Biology Institute, Yale University; West Haven, CT 06516, USA., Jensen TB; Department of Genetics, Yale School of Medicine, Yale University; New Haven, CT 06510, USA.; M.D.-Ph.D. Program, Yale University; New Haven, CT 06510, USA., Yang T; Department of Genetics, Yale School of Medicine, Yale University; New Haven, CT 06510, USA., Radda JSD; Department of Genetics, Yale School of Medicine, Yale University; New Haven, CT 06510, USA., Ruiz CF; Department of Genetics, Yale School of Medicine, Yale University; New Haven, CT 06510, USA.; Yale Cancer Biology Institute, Yale University; West Haven, CT 06516, USA., Baldissera G; Department of Genetics, Yale School of Medicine, Yale University; New Haven, CT 06510, USA., Rajaei M; Department of Biostatistics, Yale School of Public Health, Yale University; New Haven, CT 06510, USA., Townsend JP; Department of Biostatistics, Yale School of Public Health, Yale University; New Haven, CT 06510, USA.; Program in Computational Biology and Bioinformatics, Yale University; New Haven, CT 06510, USA.; Program in Genetics, Genomics, and Epigenetics, Yale Cancer Center, Yale University; New Haven, CT 06510, USA., Muzumdar MD; Department of Genetics, Yale School of Medicine, Yale University; New Haven, CT 06510, USA.; Yale Cancer Biology Institute, Yale University; West Haven, CT 06516, USA.; M.D.-Ph.D. Program, Yale University; New Haven, CT 06510, USA.; Program in Genetics, Genomics, and Epigenetics, Yale Cancer Center, Yale University; New Haven, CT 06510, USA.; Department of Internal Medicine, Section of Medical Oncology, Yale School of Medicine, Yale University; New Haven, CT 06510, USA.; Yale Combined Program in the Biological and Biomedical Sciences, Yale University; New Haven, CT 06510, USA.; Molecular Cell Biology, Genetics, and Development Program, Yale University; New Haven, CT 06510, USA., Wang S; Department of Genetics, Yale School of Medicine, Yale University; New Haven, CT 06510, USA.; M.D.-Ph.D. Program, Yale University; New Haven, CT 06510, USA.; Yale Combined Program in the Biological and Biomedical Sciences, Yale University; New Haven, CT 06510, USA.; Molecular Cell Biology, Genetics, and Development Program, Yale University; New Haven, CT 06510, USA.; Department of Cell Biology, Yale School of Medicine, Yale University; New Haven, CT 06510, USA.; Biochemistry, Quantitative Biology, Biophysics, and Structural Biology Program, Yale University; New Haven, CT 06510, USA.; Yale Center for RNA Science and Medicine, Yale University School of Medicine; New Haven, CT 06510, USA.; Yale Liver Center, Yale University School of Medicine; New Haven, CT 06510, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 09. Date of Electronic Publication: 2024 Sep 09.