Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Jens-Uwe Marquardt"'
1
Akademický článek
PRMT5 Mediated HIF1α Signaling and Ras-Related Nuclear Protein as Promising Biomarker in Hepatocellular Carcinoma
Autor: Wafaa Abumustafa, Darko Castven, Fatemeh Saheb Sharif-Askari, Batoul Abi Zamer, Mawieh Hamad, Jens-Uwe Marquardt, Jibran Sualeh Muhammad
Publikováno v: Biology, Vol 13, Iss 4, p 216 (2024)
Protein arginine N-methyltransferase 5 (PRMT5) has been identified as a potential therapeutic target for various cancer types. However, its role in regulating the hepatocellular carcinoma (HCC) transcriptome remains poorly understood. In this study,
Externí odkaz: https://doaj.org/article/7ed6f199d3964bc5b98456735e80f93e
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2
Akademický článek
RAC1b Collaborates with TAp73α-SMAD4 Signaling to Induce Biglycan Expression and Inhibit Basal and TGF-β-Driven Cell Motility in Human Pancreatic Cancer
Autor: Hendrik Ungefroren, Julissa Reimann, Björn Konukiewitz, Rüdiger Braun, Ulrich F. Wellner, Hendrik Lehnert, Jens-Uwe Marquardt
Publikováno v: Biomedicines, Vol 12, Iss 1, p 199 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type characterized by a marked desmoplastic tumor stroma that is formed under the influence of transforming growth factor (TGF)-β. Data from mouse models of pancreatic cancer have
Externí odkaz: https://doaj.org/article/75f8d918348c4e9f8c269ab2a220640b
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3
Akademický článek
Establishment and Molecular Characterization of Two Patient-Derived Pancreatic Ductal Adenocarcinoma Cell Lines as Preclinical Models for Treatment Response
Autor: Rüdiger Braun, Olha Lapshyna, Jessica Watzelt, Maren Drenckhan, Axel Künstner, Benedikt Färber, Ahmed Ahmed Mohammed Hael, Louisa Bolm, Kim Christin Honselmann, Björn Konukiewitz, Darko Castven, Malte Spielmann, Sivahari Prasad Gorantla, Hauke Busch, Jens-Uwe Marquardt, Tobias Keck, Ulrich Friedrich Wellner, Hendrik Ungefroren
Publikováno v: Cells, Vol 12, Iss 4, p 587 (2023)
The prognosis of pancreatic ductal adenocarcinoma (PDAC) is exceedingly poor. Although surgical resection is the only curative treatment option, multimodal treatment is of the utmost importance, as only about 20% of tumors are primarily resectable at
Externí odkaz: https://doaj.org/article/217dd6f9a824404c944446bfa3c6760d
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4
Akademický článek
Suppressive Role of ACVR1/ALK2 in Basal and TGFβ1-Induced Cell Migration in Pancreatic Ductal Adenocarcinoma Cells and Identification of a Self-Perpetuating Autoregulatory Loop Involving the Small GTPase RAC1b
Autor: Hendrik Ungefroren, Rüdiger Braun, Olha Lapshyna, Björn Konukiewitz, Ulrich F. Wellner, Hendrik Lehnert, Jens-Uwe Marquardt
Publikováno v: Biomedicines, Vol 10, Iss 10, p 2640 (2022)
Pancreatic ductal adenocarcinoma (PDAC) cells are known for their high invasive/metastatic potential, which is regulated in part by the transforming growth factor β1 (TGFβ1). The involvement of at least two type I receptors, ALK5 and ALK2, that tra
Externí odkaz: https://doaj.org/article/08893937907d4b909e6c3d7605ba1f5d
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5
Plasma Leptin Levels, Obstructive Sleep Apnea Syndrome, and Diabetes Are Associated with Obesity-Related Alterations of Peripheral Blood Monocyte Subsets
Autor: Svenja Meyhöfer, Armin Steffen, Kirstin Plötze-Martin, Christian Lange, Jens-Uwe Marquardt, Karl-Ludwig Bruchhage, Sebastian M. Meyhöfer, Ralph Pries
Publikováno v: ImmunoHorizons. 7:191-199
Obesity is a dramatically increasing disease, accompanied with comorbidities such as cardiovascular disease and obstructive sleep apnea syndrome (OSAS). Both obesity and OSAS per se are associated with systemic inflammation. However, the multifactori
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8699b8cf86975ce7596a77298c25bc6c
https://doi.org/10.4049/immunohorizons.2300009
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7
Differential Effects of Somatostatin, Octreotide, and Lanreotide on Neuroendocrine Differentiation and Proliferation in Established and Primary NET Cell Lines: Possible Crosstalk with TGF-β Signaling
Autor: Hendrik Ungefroren, Axel Künstner, Hauke Busch, Sören Franzenburg, Kim Luley, Fabrice Viol, Jörg Schrader, Björn Konukiewitz, Ulrich F. Wellner, Sebastian M. Meyhöfer, Tobias Keck, Jens-Uwe Marquardt, Hendrik Lehnert
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 15868
GEP-NETs are heterogeneous tumors originating from the pancreas (panNET) or the intestinal tract. Only a few patients with NETs are amenable to curative tumor resection, and for most patients, only palliative treatments to successfully control the di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1345e811fe0965e8d2be90c82c2551e2
https://pubmed.ncbi.nlm.nih.gov/36555512
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8
Markers of cell death predict therapy response in patients with cirrhosis and hepatorenal syndrome
Autor: Sophia Heinrich, Thomas Austgen, Darko Castven, Moritz Hess, Christian Labenz, Martha Kirstein, Carolin Zimpel, Lena Stockhoff, Benjamin Maasoumy, Bernd Heinrich, Hans Heinrich Wedemeyer, Peter Robert Galle, Harald Binder, Marc Nguyen‐Tat, Jens Uwe Marquardt
Publikováno v: United European gastroenterology journalREFERENCES.
Hepatorenal syndrome is a major complication in patients with cirrhosis and associated with high mortality. Predictive biomarkers for therapy response are largely missing. Cytokeratin18-based cell death markers are significantly elevated in patients
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b749144511f9b7b45db7c7438e1f7c3
https://pubmed.ncbi.nlm.nih.gov/36441143
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