Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jens-Uwe Marquardt"'
Autor:
Wafaa Abumustafa, Darko Castven, Fatemeh Saheb Sharif-Askari, Batoul Abi Zamer, Mawieh Hamad, Jens-Uwe Marquardt, Jibran Sualeh Muhammad
Publikováno v:
Biology, Vol 13, Iss 4, p 216 (2024)
Protein arginine N-methyltransferase 5 (PRMT5) has been identified as a potential therapeutic target for various cancer types. However, its role in regulating the hepatocellular carcinoma (HCC) transcriptome remains poorly understood. In this study,
Externí odkaz:
https://doaj.org/article/7ed6f199d3964bc5b98456735e80f93e
Autor:
Hendrik Ungefroren, Julissa Reimann, Björn Konukiewitz, Rüdiger Braun, Ulrich F. Wellner, Hendrik Lehnert, Jens-Uwe Marquardt
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 199 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type characterized by a marked desmoplastic tumor stroma that is formed under the influence of transforming growth factor (TGF)-β. Data from mouse models of pancreatic cancer have
Externí odkaz:
https://doaj.org/article/75f8d918348c4e9f8c269ab2a220640b
Autor:
Rüdiger Braun, Olha Lapshyna, Jessica Watzelt, Maren Drenckhan, Axel Künstner, Benedikt Färber, Ahmed Ahmed Mohammed Hael, Louisa Bolm, Kim Christin Honselmann, Björn Konukiewitz, Darko Castven, Malte Spielmann, Sivahari Prasad Gorantla, Hauke Busch, Jens-Uwe Marquardt, Tobias Keck, Ulrich Friedrich Wellner, Hendrik Ungefroren
Publikováno v:
Cells, Vol 12, Iss 4, p 587 (2023)
The prognosis of pancreatic ductal adenocarcinoma (PDAC) is exceedingly poor. Although surgical resection is the only curative treatment option, multimodal treatment is of the utmost importance, as only about 20% of tumors are primarily resectable at
Externí odkaz:
https://doaj.org/article/217dd6f9a824404c944446bfa3c6760d
Autor:
Hendrik Ungefroren, Axel Künstner, Hauke Busch, Sören Franzenburg, Kim Luley, Fabrice Viol, Jörg Schrader, Björn Konukiewitz, Ulrich F. Wellner, Sebastian M. Meyhöfer, Tobias Keck, Jens-Uwe Marquardt, Hendrik Lehnert
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15868 (2022)
GEP-NETs are heterogeneous tumors originating from the pancreas (panNET) or the intestinal tract. Only a few patients with NETs are amenable to curative tumor resection, and for most patients, only palliative treatments to successfully control the di
Externí odkaz:
https://doaj.org/article/8a63e6aa18064cb3bcbb3b785dd08a42
Autor:
Hendrik Ungefroren, Rüdiger Braun, Olha Lapshyna, Björn Konukiewitz, Ulrich F. Wellner, Hendrik Lehnert, Jens-Uwe Marquardt
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2640 (2022)
Pancreatic ductal adenocarcinoma (PDAC) cells are known for their high invasive/metastatic potential, which is regulated in part by the transforming growth factor β1 (TGFβ1). The involvement of at least two type I receptors, ALK5 and ALK2, that tra
Externí odkaz:
https://doaj.org/article/08893937907d4b909e6c3d7605ba1f5d
Autor:
Felix Thol, Simon Johannes Gairing, Carolin Czauderna, Thomas Thomaidis, Thomas Gamstätter, Yvonne Huber, Johanna Vollmar, Johanna Lorenz, Maurice Michel, Fabian Bartsch, Lukas Müller, Roman Kloeckner, Peter Robert Galle, Marcus-Alexander Wörns, Jens Uwe Marquardt, Markus Moehler, Arndt Weinmann, Friedrich Foerster
Publikováno v:
JHEP Reports, Vol 4, Iss 3, Pp 100417- (2022)
Background & Aims: Advanced biliary tract cancer (ABTC) is associated with a poor prognosis. Real-world data on the outcome of patients with ABTC undergoing sequential chemotherapies remain scarce, and little is known about treatment options beyond t
Externí odkaz:
https://doaj.org/article/ca54cc67fe5d403f87475984aa7900e7
Autor:
Svenja Meyhöfer, Armin Steffen, Kirstin Plötze-Martin, Christian Lange, Jens-Uwe Marquardt, Karl-Ludwig Bruchhage, Sebastian M. Meyhöfer, Ralph Pries
Publikováno v:
ImmunoHorizons. 7:191-199
Obesity is a dramatically increasing disease, accompanied with comorbidities such as cardiovascular disease and obstructive sleep apnea syndrome (OSAS). Both obesity and OSAS per se are associated with systemic inflammation. However, the multifactori
Publikováno v:
Gastroenterologie up2date. 18:369-388
Autor:
Sophia Heinrich, Thomas Austgen, Darko Castven, Moritz Hess, Christian Labenz, Martha Kirstein, Carolin Zimpel, Lena Stockhoff, Benjamin Maasoumy, Bernd Heinrich, Hans Heinrich Wedemeyer, Peter Robert Galle, Harald Binder, Marc Nguyen‐Tat, Jens Uwe Marquardt
Publikováno v:
United European gastroenterology journalREFERENCES.
Hepatorenal syndrome is a major complication in patients with cirrhosis and associated with high mortality. Predictive biomarkers for therapy response are largely missing. Cytokeratin18-based cell death markers are significantly elevated in patients
Autor:
Simon Johannes Gairing, Robert Kuchen, Lukas Müller, Alper Cankaya, Jan Weerts, Akin Kapucu, Simon Sachse, Carolin Zimpel, Fabian Stoehr, Michael B. Pitton, Jens Mittler, Beate Katharina Straub, Jens Uwe Marquardt, Jörn M. Schattenberg, Christian Labenz, Roman Kloeckner, Arndt Weinmann, Peter Robert Galle, Marcus-Alexander Wörns, Friedrich Foerster
Publikováno v:
Clinical and translational gastroenterology. 13(10)
The 13 C-methacetin breath test ( 13 C-MBT) is a dynamic method for assessing liver function. This proof-of-concept study aimed to investigate the association between 13 C-MBT values and outcomes in patients with hepatocellular carcinoma (HCC) underg