Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Jens Y, Humrich"'
Autor:
Stefan Rosenberger, Reinmar Undeutsch, Reza Akbarzadeh, Justus Ohmes, Philipp Enghard, Gabriela Riemekasten, Jens Y. Humrich
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionProgressive loss of regulatory T cell (Treg)-mediated control over autoreactive effector T cells contributes to the development of systemic lupus erythematosus (SLE). Accordingly, we hypothesized that Treg may also have the capacity to su
Externí odkaz:
https://doaj.org/article/fe8d1c2579bb4584a528e5e7932965ff
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Systemic sclerosis (SSc) is a chronic, multisystem connective tissue, and autoimmune disease with the highest case-specific mortality and complications among rheumatic diseases. It is characterized by complex and variable features such as autoimmunit
Externí odkaz:
https://doaj.org/article/aa2478da932b4365b44898f2604c5125
Autor:
Otavio Cabral-Marques, Gilad Halpert, Lena F. Schimke, Yuri Ostrinski, Aristo Vojdani, Gabriela Crispim Baiocchi, Paula Paccielli Freire, Igor Salerno Filgueiras, Israel Zyskind, Miriam T. Lattin, Florian Tran, Stefan Schreiber, Alexandre H. C. Marques, Desirée Rodrigues Plaça, Dennyson Leandro M. Fonseca, Jens Y. Humrich, Antje Müller, Lasse M. Giil, Hanna Graßhoff, Anja Schumann, Alexander Hackel, Juliane Junker, Carlotta Meyer, Hans D. Ochs, Yael Bublil Lavi, Carmen Scheibenbogen, Ralf Dechend, Igor Jurisica, Kai Schulze-Forster, Jonathan I. Silverberg, Howard Amital, Jason Zimmerman, Harry Heidecke, Avi Z. Rosenberg, Gabriela Riemekasten, Yehuda Shoenfeld
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
COVID-19, similarly to systemic autoimmune diseases, is characterised by the presence of autoantibodies. Authors show here that the abundance and network signature of autoantibodies targeting G protein-coupled receptors and RAS-related proteins are a
Externí odkaz:
https://doaj.org/article/0bbb149f6584414f963ec84a8ac62f94
Autor:
Florian Tran, Danielle M.M. Harris, Alena Scharmacher, Hanna Graßhoff, Kristina Sterner, Susanne Schinke, Nadja Käding, Jens Y. Humrich, Otávio Cabral-Marques, Joana P. Bernardes, Neha Mishra, Thomas Bahmer, Jeanette Franzenburg, Bimba F. Hoyer, Andreas Glück, Martina Guggeis, Alexander Ossysek, Andre Küller, Derk Frank, Christoph Lange, Jan Rupp, Jan Heyckendorf, Karoline I. Gaede, Howard Amital, Philip Rosenstiel, Yehuda Shoenfeld, Gilad Halpert, Avi Z. Rosenberg, Kai Schulze-Forster, Harald Heidecke, Gabriela Riemekasten, Stefan Schreiber
Publikováno v:
ERJ Open Research, Vol 8, Iss 4 (2022)
Externí odkaz:
https://doaj.org/article/691defcda09b4e119f6b69f200851390
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In the normal immune system, T cell activation is tightly regulated and controlled at several levels to ensure that activation occurs in the right context to prevent the development of pathologic conditions such as autoimmunity or other harmful immun
Externí odkaz:
https://doaj.org/article/0ccd4200f9ca4358b17681cc47944ebe
Autor:
Hanna Graßhoff, Sara Comdühr, Luisa R. Monne, Antje Müller, Peter Lamprecht, Gabriela Riemekasten, Jens Y. Humrich
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Regulatory T cells (Treg) are crucial for the maintenance of peripheral tolerance and for the control of ongoing inflammation and autoimmunity. The cytokine interleukin-2 (IL-2) is essentially required for the growth and survival of Treg in the perip
Externí odkaz:
https://doaj.org/article/b01bf753314b4a9f9b56c2ba976e9d02
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Immunophenotyping on the molecular and cellular level is a central aspect for characterization of patients with inflammatory diseases, both to better understand disease etiopathogenesis and based on this to develop diagnostic and prognostic biomarker
Externí odkaz:
https://doaj.org/article/9c2e7f0d61bd446b8960bd6310295262
Autor:
Otavio Cabral-Marques, Alexandre Marques, Lasse Melvær Giil, Roberta De Vito, Judith Rademacher, Jeannine Günther, Tanja Lange, Jens Y. Humrich, Sebastian Klapa, Susanne Schinke, Lena F. Schimke, Gabriele Marschner, Silke Pitann, Sabine Adler, Ralf Dechend, Dominik N. Müller, Ioana Braicu, Jalid Sehouli, Kai Schulze-Forster, Tobias Trippel, Carmen Scheibenbogen, Annetine Staff, Peter R. Mertens, Madlen Löbel, Justin Mastroianni, Corinna Plattfaut, Frank Gieseler, Duska Dragun, Barbara Elizabeth Engelhardt, Maria J. Fernandez-Cabezudo, Hans D. Ochs, Basel K. al-Ramadi, Peter Lamprecht, Antje Mueller, Harald Heidecke, Gabriela Riemekasten
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Autoantibodies are implicated in autoimmunity, but may also be present in healthy individuals. Here the authors find that the autoantibody specificity signatures against various G protein-coupled receptors are associated with multiple parameters, inc
Externí odkaz:
https://doaj.org/article/ce22418439234ad18d21d372dba2db52
Autor:
Peter Lamprecht, Anja Kerstein, Sebastian Klapa, Susanne Schinke, Christian M. Karsten, Xinhua Yu, Marc Ehlers, Jörg T. Epplen, Konstanze Holl-Ulrich, Thorsten Wiech, Kathrin Kalies, Tanja Lange, Martin Laudien, Tamas Laskay, Timo Gemoll, Udo Schumacher, Sebastian Ullrich, Hauke Busch, Saleh Ibrahim, Nicole Fischer, Katrin Hasselbacher, Ralph Pries, Frank Petersen, Gesche Weppner, Rudolf Manz, Jens Y. Humrich, Relana Nieberding, Gabriela Riemekasten, Antje Müller
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Anti-neutrophil cytoplasmic autoantibodies (ANCA) targeting proteinase 3 (PR3) and myeloperoxidase expressed by innate immune cells (neutrophils and monocytes) are salient diagnostic and pathogenic features of small vessel vasculitis, comprising gran
Externí odkaz:
https://doaj.org/article/3c4143f1c46040ea99bc33548a389fea
Autor:
Angelika Rose, Caroline von Spee-Mayer, Lutz Kloke, Kaiyin Wu, Anja Kühl, Philipp Enghard, Gerd-Rüdiger Burmester, Gabriela Riemekasten, Jens Y. Humrich
Publikováno v:
Cells, Vol 8, Iss 10, p 1234 (2019)
An acquired deficiency of interleukin-2 (IL-2) and related disturbances in regulatory T cell (Treg) homeostasis play an important role in the pathogenesis of systemic lupus erythematosus (SLE). Low-dose IL-2 therapy was shown to restore Treg homeosta
Externí odkaz:
https://doaj.org/article/6c6ebae72a8047be855d2126190e7c85