Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jens Wolfard"'
Autor:
David F. Nippa, Kenneth Atz, Alex T. Müller, Jens Wolfard, Clemens Isert, Martin Binder, Oliver Scheidegger, David B. Konrad, Uwe Grether, Rainer E. Martin, Gisbert Schneider
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Enhancing the properties of advanced drug candidates is aided by the direct incorporation of specific chemical groups, avoiding the need to construct the entire compound from the ground up. Nevertheless, their chemical intricacy often poses
Externí odkaz:
https://doaj.org/article/0c3ef404943e479386fe466df39811e2
Autor:
David F. Nippa, Kenneth Atz, Alex T. Müller, Jens Wolfard, Clemens Isert, Martin Binder, Oliver Scheidegger, David B. Konrad, Uwe Grether, Rainer E. Martin, Gisbert Schneider
Optimizing the properties of advanced drug candidates can be facilitated by directly introducing certain chemical groups without having to synthesize the molecules from scratch. However, their chemical complexity often renders reactivity predictions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::496094363bb7b38f70377b58eee6febd
https://doi.org/10.26434/chemrxiv-2023-8hdmv
https://doi.org/10.26434/chemrxiv-2023-8hdmv
Autor:
David F. Nippa, Kenneth Atz, Remo Hohler, Alex T. Müller, Andreas Marx, Christian Bartelmus, Georg Wuitschik, Irene Marzuoli, Vera Jost, Jens Wolfard, Martin Binder, Antonia F. Stepan, David B. Konrad, Uwe Grether, Rainer E. Martin, Gisbert Schneider
Late-stage functionalization (LSF) is an economical approach to optimize the properties of drug candidates. However, the chemical complexity of drug molecules often makes late-stage diversification challenging. To address this problem, an LSF platfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e94ba64b1839e2dc654f462367284c
https://doi.org/10.26434/chemrxiv-2022-gkxm6-v2
https://doi.org/10.26434/chemrxiv-2022-gkxm6-v2
Autor:
Nippa, David F.1,2 (AUTHOR), Atz, Kenneth3 (AUTHOR), Müller, Alex T.1 (AUTHOR), Wolfard, Jens1 (AUTHOR), Isert, Clemens3 (AUTHOR), Binder, Martin1 (AUTHOR), Scheidegger, Oliver1 (AUTHOR), Konrad, David B.2 (AUTHOR) david.konrad@cup.lmu.de, Grether, Uwe1 (AUTHOR) uwe.grether@roche.com, Martin, Rainer E.1 (AUTHOR) rainer_e.martin@roche.com, Schneider, Gisbert3 (AUTHOR) gisbert@ethz.ch
Publikováno v:
Communications Chemistry. 11/20/2023, Vol. 6 Issue 1, p1-11. 11p.