Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Jens Waschke"'
Autor:
Sina Moztarzadeh, Sara Sepic, Ibrahim Hamad, Jens Waschke, Mariya Y. Radeva, Alexander García-Ponce
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Vascular permeability is mediated by Cortactin (Cttn) and regulated by several molecules including cyclic-adenosine-monophosphate, small Rho family GTPases and the actin cytoskeleton. However, it is unclear whether Cttn directly interacts wi
Externí odkaz:
https://doaj.org/article/9b742ba604454b9e89c3d5e3445d2ae8
Autor:
Juna-Lisa Knop, Natalie Burkard, Mahshid Danesh, Sebastian Kintrup, Thomas Dandekar, Mugdha Srivastava, Rebecca Springer, Matthias Hiermaier, Nana-Maria Wagner, Jens Waschke, Sven Flemming, Nicolas Schlegel
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108049- (2023)
Summary: Breakdown of endothelial barrier integrity determines organ dysfunction and outcome of patients with sepsis. Increased levels of soluble vascular endothelial (VE)-cadherin fragments (sVE-cadherin) have previously been linked with inflammatio
Externí odkaz:
https://doaj.org/article/b7ca474599744819a3b24f21ed44a516
Autor:
Anna M. Sigmund, Markus Winkler, Sophia Engelmayer, Daniela Kugelmann, Desalegn T. Egu, Letyfee S. Steinert, Michael Fuchs, Matthias Hiermair, Mariya Y. Radeva, Franziska C. Bayerbach, Elisabeth Butz, Stefan Kotschi, Christoph Hudemann, Michael Hertl, Sunil Yeruva, Enno Schmidt, Amir S. Yazdi, Kamran Ghoreschi, Franziska Vielmuth, Jens Waschke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies which destabilize cell adhesion of keratinocytes. The phosphodiesterase 4 inhibitor apremilast prevents skin blistering by stabilizing the keratin filament anch
Externí odkaz:
https://doaj.org/article/a933bd3a4505443a83704c045d6c6602
Autor:
Sina Moztarzadeh, Mariya Y. Radeva, Sara Sepic, Katharina Schuster, Ibrahim Hamad, Jens Waschke, Alexander García-Ponce
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Adducin (Add) is an actin binding protein participating in the stabilization of actin/spectrin networks, epithelial junctional turnover and cardiovascular disorders such as hypertension. Recently, we demonstrated that Add is required for adh
Externí odkaz:
https://doaj.org/article/5e24de4b0ae84ce5960eca3d9c9a20ab
Autor:
Thomas Schmitt, Christoph Hudemann, Sina Moztarzadeh, Michael Hertl, Ritva Tikkanen, Jens Waschke
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPemphigus is an autoantibody driven disease that impairs the barrier function of the skin and mucosa by disrupting desmosomes and thereby impeding cellular cohesion. It is known that the different clinical phenotypes of pemphigus vulgaris
Externí odkaz:
https://doaj.org/article/5b41d7ba431f4dc7be55d92a1827209e
Autor:
Maria Shoykhet, Orsela Dervishi, Philipp Menauer, Matthias Hiermaier, Sina Moztarzadeh, Colin Osterloh, Ralf J. Ludwig, Tatjana Williams, Brenda Gerull, Stefan Kääb, Sebastian Clauss, Dominik Schüttler, Jens Waschke, Sunil Yeruva
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
Arrhythmogenic cardiomyopathy (AC) is a familial heart disease partly caused by impaired desmosome turnover. Thus, stabilization of desmosome integrity may provide new treatment options. Desmosomes, apart from cellular cohesion, provide the structura
Externí odkaz:
https://doaj.org/article/2beededbb67b40438a622d5e5d48e306
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
A Disintegrin And Metalloprotease (ADAM) family proteins are involved in several cardiac diseases, and some ADAMs have been associated with cardiomyopathies. ADAM17 is known to cleave desmoglein 2 (DSG2), one of the proteins involved in the pathogene
Externí odkaz:
https://doaj.org/article/d6004f7e95a64e4cb2c8d70fd9870bd1
Autor:
Ramona A. Eichkorn, Morna F. Schmidt, Elias Walter, Michael Hertl, Jens Malte Baron, Jens Waschke, Amir S. Yazdi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Molecular mechanisms underlying auto-antibody-induced acantholysis in pemphigus vulgaris are subject of current research to date. To decipher the discrepancy between ubiquitous antibody binding to the epidermal desmosomes, but discontinuous disease m
Externí odkaz:
https://doaj.org/article/8f58a2610e804d33bb3ea13d2f772f35
Autor:
Daniela Kugelmann, Maresa Anders, Anna M. Sigmund, Desalegn T. Egu, Ramona A. Eichkorn, Amir S. Yazdi, Miklós Sárdy, Michael Hertl, Dario Didona, Takashi Hashimoto, Jens Waschke
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The severe autoimmune blistering disease Pemphigus vulgaris (PV) is mainly caused by autoantibodies (IgG) against desmoglein (Dsg) 3 and Dsg1. The mechanisms leading to the development of blisters are not fully understood, but intracellular signaling
Externí odkaz:
https://doaj.org/article/bf9ecf11ae6e48e982490804fb4a2c1c
Autor:
Martina Meßner, Melanie M. Mandl, Mathias W. Hackl, Till Reinhardt, Maximilian A. Ardelt, Karolina Szczepanowska, Julian E. Frädrich, Jens Waschke, Irmela Jeremias, Anja Fux, Matthias Stahl, Angelika M. Vollmar, Stephan A. Sieber, Johanna Pachmayr
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The human mitochondrial ClpXP protease complex (HsClpXP) has recently attracted major attention as a target for novel anti-cancer therapies. Despite its important role in disease progression, the cellular role of HsClpXP is poorly characteri
Externí odkaz:
https://doaj.org/article/547435541d554b50bc1ec5f3fc98a476