Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency

Autor: Melanie Werner-Klein, Ana Grujovic, Christoph Irlbeck, Milan Obradović, Martin Hoffmann, Huiqin Koerkel-Qu, Xin Lu, Steffi Treitschke, Cäcilia Köstler, Catherine Botteron, Kathrin Weidele, Christian Werno, Bernhard Polzer, Stefan Kirsch, Miodrag Gužvić, Jens Warfsmann, Kamran Honarnejad, Zbigniew Czyz, Giancarlo Feliciello, Isabell Blochberger, Sandra Grunewald, Elisabeth Schneider, Gundula Haunschild, Nina Patwary, Severin Guetter, Sandra Huber, Brigitte Rack, Nadia Harbeck, Stefan Buchholz, Petra Rümmele, Norbert Heine, Stefan Rose-John, Christoph A. Klein

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

Metastatic dissemination in breast cancer patients occurs early in malignant transformation, raising questions about how disseminated cancer cells (DCC) progress at distant sites. Here, the authors show that DCCs in bone marrow are activated via IL6-

Externí odkaz: https://doaj.org/article/852fb79d2cfa456b923be4f3ce115b15

Quiescence-inducing 3D-engineered matrix uncovers mechanosensitive and drug protective FHL2-p21 signaling axis

Autor: Sadra Bakhshandeh, Hubert M. Taïeb, Adithi R. Varadarajan, Susanna M. Lissek, Sarah M. Hücker, Xin Lu, Daniela S. Garske, Sarah A. E. Young, Jörg Contzen, Manfred Gossen, Stefan Kirsch, Jens Warfsmann, Kamran Honarnejad, Christoph A. Klein, Amaia Cipitria

Resected tumors frequently relapse with distant metastasis, despite systemic treatment. Cellular quiescence has been identified as an important mechanism underlying such drug resistance enabling late relapse. Nonetheless, hurdles associated with dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82a24605666b1a7b87c30e6988c35238
https://doi.org/10.1101/2023.01.25.525382

mdm2 gene amplification is associated with luminal breast cancer progression in humanized PDX mice and a worse outcome of estrogen receptor positive disease

Autor: Anja Kathrin Wege, Eva‐Maria Rom‐Jurek, Paul Jank, Carsten Denkert, Peter Ugocsai, Christine Solbach, Jens‐Uwe Blohmer, Bruno Sinn, Marion Mackelenbergh, Volker Möbus, Andreas Trumpp, Elisabetta Marangoni, Nicole Pfarr, Christoph Irlbeck, Jens Warfsmann, Bernhard Polzer, Florian Weber, Olaf Ortmann, Sibylle Loibl, Valentina Vladimirova, Gero Brockhoff

Publikováno v: International journal of cancerREFERENCES. 150(8)

Estrogen receptor-positive breast cancer is a highly prevalent but heterogeneous disease among women. Advanced molecular stratification is required to enable individually most efficient treatments based on relevant prognostic and predictive biomarker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ebf18cff910f6ab631dcd954b1883a
https://pubmed.ncbi.nlm.nih.gov/34927257

Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during periods of clinical latency

Autor: Huiqin Koerkel-Qu, Sandra Grunewald, Stefan Rose-John, Stefan Kirsch, Melanie Werner-Klein, Martin Hoffmann, Severin Guetter, Isabell Blochberger, Catherine Botteron, Elisabeth Schneider, Petra Ruemmele, Miodrag Guzvic, Stefan Buchholz, Gundula Haunschild, Kamran Honarnejad, Christoph Klein, Christoph Irlbeck, Nina Patwary, Sandra Huber, Caecilia Koestler, Kathrin Weidele, Ana Grujovic, Milan Obradovic, Zbigniew T. Czyz, Steffie Treitschke, Norbert Heine, Xin Lu, Jens Warfsmann, Bernhard Polzer, Christian Werno

Although thousands of breast cancer cells disseminate and home to bone marrow until primary surgery, usually less than a handful will succeed in establishing manifest metastases months to years later. To identify signals that support survival or outg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6e8f731ee4d130ef1923858cc0248cb
https://doi.org/10.1101/2020.05.28.121145

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury

Autor: Yuan Zhuang, Dirk Brenner, Verena Keitel, Haifeng C. Xu, Philipp A. Lang, Ertan Mayatepek, Diran Herebian, Mohamed S. Taha, Prashant V. Shinde, Klaus Pfeffer, Karl S. Lang, Kristina Behnke, Balamurugan Sundaram, Dieter Häussinger, Jens Warfsmann, Jelena Vasilevska, Aleksandra A. Pandyra, Mohammad Reza Ahmadian, Jessica I. Hoell, Dagmar Wieczorek, Jun Huang, Arndt Borkhardt

Publikováno v: Zhuang, Y, Xu, H C, Shinde, P V, Warfsmann, J, Vasilevska, J, Sundaram, B, Behnke, K, Huang, J, Hoell, J I, Borkhardt, A, Pfeffer, K, Taha, M S, Herebian, D, Mayatepek, E, Brenner, D, Ahmadian, M R, Keitel, V, Wieczorek, D, Häussinger, D, Pandyra, A A, Lang, K S & Lang, P A 2020, ' Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury ', Gut, vol. 69, no. 1, pp. 133-145 . https://doi.org/10.1136/gutjnl-2019-318215

ObjectiveThe Fragile X mental retardation (FMR) syndrome is a frequently inherited intellectual disability caused by decreased or absent expression of the FMR protein (FMRP). Lack of FMRP is associated with neuronal degradation and cognitive dysfunct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8035b8aa4f85ff7afda6e7042856a9
https://pubmed.ncbi.nlm.nih.gov/31554707