Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus

Autor: Theresa S. Rimmele, Shaomin Li, Jens Velde Andersen, Emil W. Westi, Alexander Rotenberg, Jianlin Wang, Blanca Irene Aldana, Dennis J. Selkoe, Chiye J. Aoki, Chris G. Dulla, Paul Allen Rosenberg

Publikováno v: Frontiers in Cellular Neuroscience, Vol 15 (2021)

GLT-1, the major glutamate transporter in the mammalian central nervous system, is expressed in presynaptic terminals that use glutamate as a neurotransmitter, in addition to astrocytes. It is widely assumed that glutamate homeostasis is regulated pr

Externí odkaz: https://doaj.org/article/bd922351081f490ab166d4b63a3be5b0

Milestone Review: Metabolic dynamics of glutamate and GABA mediated neurotransmission — The essential roles of astrocytes

Autor: Arne Schousboe, Jens Velde Andersen

Publikováno v: Andersen, J V & Schousboe, A 2023, ' Milestone Review : Metabolic dynamics of glutamate and GABA mediated neurotransmission — The essential roles of astrocytes ', Journal of Neurochemistry, vol. 166, no. 2, pp. 109-137 . https://doi.org/10.1111/jnc.15811

Since it was first generally accepted that the two amino acids glutamate and GABA act as principal neurotransmitters, several landmark discoveries relating to this function have been uncovered. Synaptic homeostasis of these two transmitters involves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6028bc446d1d06acb0ca8d74261a7a7d
https://doi.org/10.1111/jnc.15811

Progressive Mitochondrial Dysfunction of Striatal Synapses in R6/2 Mouse Model of Huntington's Disease

Autor: Maria Hvidberg Petersen, Cecilie Wennemoes Willert, Jens Velde Andersen, Mette Madsen, Helle Sønderby Waagepetersen, Niels Henning Skotte, Anne Nørremølle

Publikováno v: Journal of Huntington's disease. 11(2)

Background: Huntington’s disease (HD) is a neurodegenerative disorder characterized by synaptic dysfunction and loss of white matter volume especially in the striatum of the basal ganglia and to a lesser extent in the cerebral cortex. Studies inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63688c6101d57aac431866c6f9df378
https://pubmed.ncbi.nlm.nih.gov/35311711

Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand. Role of ammonia-induced increased GABAergic tone

Autor: Michael Sørensen, Anne Byriel Walls, Gitte Dam, Lasse Kristoffer Bak, Jens Velde Andersen, Peter Ott, Hendrik Vilstrup, Arne Schousboe

Publikováno v: Sørensen, M, Walls, A B, Dam, G, Bak, L K, Andersen, J V, Ott, P, Vilstrup, H & Schousboe, A 2022, ' Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand. Role of ammonia-induced increased GABAergic tone ', Analytical Biochemistry, vol. 654, 114766 . https://doi.org/10.1016/j.ab.2022.114766

Hepatic encephalopathy (HE) is a frequent and devastating but generally reversible neuropsychiatric complication secondary to chronic and acute liver failure. During HE, brain energy metabolism is markedly reduced and it remains unclear whether this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecc6e88b0e7f6f2416120f3adbe4b9a
https://doi.org/10.1016/j.ab.2022.114766

Review for 'Entering a new era of quantifying glutamate clearance in health and disease'

Autor: Jens Velde Andersen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ac58f714d58533a06fdf47ea45b468
https://doi.org/10.1002/jnr.24810/v1/review1