Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Jens V Stein"'
Autor:
Jenifer C Kaldun, Shahnaz R Lone, Ana M Humbert Camps, Cornelia Fritsch, Yves F Widmer, Jens V Stein, Seth M Tomchik, Simon G Sprecher
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001412 (2021)
Alzheimer disease (AD) is one of the main causes of age-related dementia and neurodegeneration. However, the onset of the disease and the mechanisms causing cognitive defects are not well understood. Aggregation of amyloidogenic peptides is a patholo
Externí odkaz:
https://doaj.org/article/58cca99fbadd4f4a824ce76c47662ce6
Autor:
Mariana De Niz, Jessica Kehrer, Nicolas M B Brancucci, Federica Moalli, Emmanuel G Reynaud, Jens V Stein, Friedrich Frischknecht
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238134 (2020)
Malaria is a life-threatening disease, caused by Apicomplexan parasites of the Plasmodium genus. The Anopheles mosquito is necessary for the sexual replication of these parasites and for their transmission to vertebrate hosts, including humans. Imagi
Externí odkaz:
https://doaj.org/article/be9ec899051142d9b9b87742dc8b579f
Autor:
Mario Novkovic, Lucas Onder, Jovana Cupovic, Jun Abe, David Bomze, Viviana Cremasco, Elke Scandella, Jens V Stein, Gennady Bocharov, Shannon J Turley, Burkhard Ludewig
Publikováno v:
PLoS Biology, Vol 14, Iss 7, p e1002515 (2016)
Fibroblastic reticular cells (FRCs) form the cellular scaffold of lymph nodes (LNs) and establish distinct microenvironmental niches to provide key molecules that drive innate and adaptive immune responses and control immune regulatory processes. Her
Externí odkaz:
https://doaj.org/article/afacd1170e1b46d2837051a68b3869c0
Autor:
Federica M. Conedera, Despina Kokona, Martin S. Zinkernagel, Jens V. Stein, Charles P. Lin, Clemens Alt, Volker Enzmann
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Retinal degeneration results from disruptions in retinal homeostasis due to injury, disease, or aging and triggers peripheral leukocyte infiltration. Effective immune responses rely on coordinated actions of resident microglia and
Externí odkaz:
https://doaj.org/article/916c1fd49e544c4fb67ae384fc06888f
Autor:
Mona O. Mohsen, Matthew D. Heath, Gustavo Cabral-Miranda, Cyrill Lipp, Andris Zeltins, Marcos Sande, Jens V. Stein, Carsten Riether, Elisa Roesti, Lisha Zha, Paul Engeroff, Aadil El-Turabi, Thomas M. Kundig, Monique Vogel, Murray A. Skinner, Daniel E. Speiser, Alexander Knuth, Matthias F. Kramer, Martin F. Bachmann
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Induction of strong T cell responses, in particular cytotoxic T cells, is a key for the generation of efficacious therapeutic cancer vaccines which yet, remains a major challenge for the vaccine developing world. Here we demonstra
Externí odkaz:
https://doaj.org/article/990f850b12da41e5993abd4c2dba075c
Autor:
Laura Sanz-Ortega, José M. Rojas, Ana Marcos, Yadileiny Portilla, Jens V. Stein, Domingo F. Barber
Publikováno v:
Journal of Nanobiotechnology, Vol 17, Iss 1, Pp 1-20 (2019)
Abstract Background T lymphocytes are highly dynamic elements of the immune system with a tightly regulated migration. T cell-based transfer therapies are promising therapeutic approaches which in vivo efficacy is often limited by the small proportio
Externí odkaz:
https://doaj.org/article/ae6b268b298442dbb8202bcc80b0afe1
Autor:
Stefan Milutinovic, Jun Abe, Emma Jones, Inken Kelch, Kathryn Smart, Sarah N. Lauder, Michelle Somerville, Carl Ware, Andrew Godkin, Jens V. Stein, Gib Bogle, Awen Gallimore
Publikováno v:
Cancer Research Communications. 2:1641-1656
High endothelial venules (HEV) are specialized post capillary venules that recruit naïve T cells and B cells into secondary lymphoid organs (SLO) such as lymph nodes (LN). Expansion of HEV networks in SLOs occurs following immune activation to suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f421d60081ee93185577183075cec8d
https://doi.org/10.1158/2767-9764.crc-21-0123
https://doi.org/10.1158/2767-9764.crc-21-0123
Autor:
Neda Haghayegh Jahromi, Luca Marchetti, Federica Moalli, Donovan Duc, Camilla Basso, Heidi Tardent, Elisa Kaba, Urban Deutsch, Caroline Pot, Federica Sallusto, Jens V. Stein, Britta Engelhardt
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), myelin-specific T cells are activated in the periphery and differentiate in T helper (Th) 1 and Th17 effector cells, which cross the blood-brain barrier (
Externí odkaz:
https://doaj.org/article/1892b1576fe14ed993834d7fed2d5ea3
Autor:
Frank P. Assen, Jun Abe, Miroslav Hons, Robert Hauschild, Shayan Shamipour, Walter A. Kaufmann, Tommaso Costanzo, Gabriel Krens, Markus Brown, Burkhard Ludewig, Simon Hippenmeyer, Carl-Philipp Heisenberg, Wolfgang Weninger, Edouard Hannezo, Sanjiv A. Luther, Jens V. Stein, Michael Sixt
Publikováno v:
Nature Immunology. 23:1246-1255
Lymph nodes (LNs) comprise two main structural elements: fibroblastic reticular cells that form dedicated niches for immune cell interaction and capsular fibroblasts that build a shell around the organ. Immunological challenge causes LNs to increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7fc21304d69d6ec029ae8be77a22618
https://doi.org/10.1038/s41590-022-01257-4
https://doi.org/10.1038/s41590-022-01257-4
Autor:
Sujana Sivapatham, Xenia Ficht, Juliana Barreto de Albuquerque, Nicolas Page, Doron Merkler, Jens V. Stein
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
T cell activation in lymphoid tissue occurs through interactions with cognate peptide-major histocompatibility complex (pMHC)-presenting dendritic cells (DCs). Intravital imaging studies using ex vivo peptide-pulsed DCs have uncovered that cognate pM
Externí odkaz:
https://doaj.org/article/13270ed9fe624790a21c2fd182857a09