Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Jens V Stein"'
Autor:
Federica M. Conedera, Despina Kokona, Martin S. Zinkernagel, Jens V. Stein, Charles P. Lin, Clemens Alt, Volker Enzmann
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Retinal degeneration results from disruptions in retinal homeostasis due to injury, disease, or aging and triggers peripheral leukocyte infiltration. Effective immune responses rely on coordinated actions of resident microglia and
Externí odkaz:
https://doaj.org/article/916c1fd49e544c4fb67ae384fc06888f
Autor:
Federica M. Conedera, Judith M. Runnels, Jens V. Stein, Clemens Alt, Volker Enzmann, Charles P. Lin
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-22 (2023)
Abstract Background Retinal degeneration is a disease affecting the eye, which is an immune-privileged site because of its anatomical and physiological properties. Alterations in retinal homeostasis—because of injury, disease, or aging—initiate i
Externí odkaz:
https://doaj.org/article/f5536de96706455296677f8e9dd16d31
Autor:
Diego von Werdt, Bilgi Gungor, Juliana Barreto de Albuquerque, Thomas Gruber, Daniel Zysset, Cheong K. C. Kwong Chung, Antonia Corrêa-Ferreira, Regina Berchtold, Nicolas Page, Mirjam Schenk, John H. Kehrl, Doron Merkler, Beat A. Imhof, Jens V. Stein, Jun Abe, Gleb Turchinovich, Daniela Finke, Adrian C. Hayday, Nadia Corazza, Christoph Mueller
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Members of the Regulator of G-protein signaling (Rgs) family regulate the extent and timing of G protein signaling by increasing the GTPase activity of Gα protein subunits. The Rgs family member Rgs1 is one of the most up-regulated genes in tissue-r
Externí odkaz:
https://doaj.org/article/6d79eafde35e4c45ade9ec45a1191aae
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Naive B cells use the chemokine receptor CXCR5 to enter B cell follicles, where they scan CXCL13-expressing ICAM-1+ VCAM-1+ follicular dendritic cells (FDCs) for the presence of antigen. CXCL13-CXCR5-mediated motility is mainly driven by the Rac guan
Externí odkaz:
https://doaj.org/article/271c322feb1741a78daf35683af79de4
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/4efbf611167548fcb684783457ed6650
Autor:
Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes
Externí odkaz:
https://doaj.org/article/a29fe9ea7a8d465093c19a3301a148f3
Autor:
Jenifer C Kaldun, Shahnaz R Lone, Ana M Humbert Camps, Cornelia Fritsch, Yves F Widmer, Jens V Stein, Seth M Tomchik, Simon G Sprecher
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001412 (2021)
Alzheimer disease (AD) is one of the main causes of age-related dementia and neurodegeneration. However, the onset of the disease and the mechanisms causing cognitive defects are not well understood. Aggregation of amyloidogenic peptides is a patholo
Externí odkaz:
https://doaj.org/article/58cca99fbadd4f4a824ce76c47662ce6
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
To effectively navigate complex tissue microenvironments, immune cells sense molecular concentration gradients using G-protein coupled receptors. However, due to the complexity of receptor activity, and the multimodal nature of chemokine gradients in
Externí odkaz:
https://doaj.org/article/6eb0626067c14dae95482605da0c95c2
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Naïve T cells (TN) constitutively recirculate through secondary lymphatic organs (SLOs), where they scan dendritic cells (DCs) for cognate peptide-loaded major histocompatibility complexes (pMHC). Continuous trafficking between SLOs not only enables
Externí odkaz:
https://doaj.org/article/dae30e21212b4a0c8a6ea7ff4f9ef814
Autor:
Mona O. Mohsen, Matthew D. Heath, Gustavo Cabral-Miranda, Cyrill Lipp, Andris Zeltins, Marcos Sande, Jens V. Stein, Carsten Riether, Elisa Roesti, Lisha Zha, Paul Engeroff, Aadil El-Turabi, Thomas M. Kundig, Monique Vogel, Murray A. Skinner, Daniel E. Speiser, Alexander Knuth, Matthias F. Kramer, Martin F. Bachmann
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Induction of strong T cell responses, in particular cytotoxic T cells, is a key for the generation of efficacious therapeutic cancer vaccines which yet, remains a major challenge for the vaccine developing world. Here we demonstra
Externí odkaz:
https://doaj.org/article/990f850b12da41e5993abd4c2dba075c