Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jens Uldum Erlandsen"'
Autor:
Josephine Geertsen Keller, Kirstine Mejlstrup Hymøller, Maria Eriksen Thorsager, Noriko Y Hansen, Jens Uldum Erlandsen, Cinzia Tesauro, Anne Katrine W Simonsen, Anne Bech Andersen, Kamilla Vandsø Petersen, Lise Lolle Holm, Magnus Stougaard, Brage Storstein Andresen, Peter Kristensen, Rikke Frøhlich, Birgitta R Knudsen
Publikováno v:
Keller, J G, Hymøller, K M, Thorsager, M E, Hansen, N Y, Erlandsen, J U, Tesauro, C, Simonsen, A K W, Andersen, A B, VandsøPetersen, K, Holm, L L, Stougaard, M, Andresen, B S, Kristensen, P, Frøhlich, R & Knudsen, B R 2022, ' Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation ', Nucleic Acids Research, vol. 50, no. 11, pp. 6332-6342 . https://doi.org/10.1093/nar/gkac482
Keller, J G, Hymøller, K M, Thorsager, M E, Hansen, N Y, Erlandsen, J U, Tesauro, C, Simonsen, A K W, Andersen, A B, Vandsø Petersen, K, Holm, L L, Stougaard, M, Andresen, B S, Kristensen, P, Frøhlich, R & Knudsen, B R 2022, ' Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation ', Nucleic Acids Research, vol. 50, no. 11, pp. 6332-6342 . https://doi.org/10.1093/nar/gkac482
Keller, J G, Hymøller, K M, Thorsager, M E, Hansen, N Y, Erlandsen, J U, Tesauro, C, Simonsen, A K W, Andersen, A B, Vandsø Petersen, K, Holm, L L, Stougaard, M, Andresen, B S, Kristensen, P, Frøhlich, R & Knudsen, B R 2022, ' Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation ', Nucleic Acids Research, vol. 50, no. 11, pp. 6332-6342 . https://doi.org/10.1093/nar/gkac482
We have investigated the function of human topoisomerase 1 (TOP1) in regulation of G-quadruplex (G4) formation in the Pu27 region of the MYC P1 promoter. Pu27 is among the best characterized G4 forming sequences in the human genome and it is well kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606b4feca49e6ce6db36ead898879b1b
https://vbn.aau.dk/da/publications/547d3b84-5a5b-4882-947d-67ad863246d1
https://vbn.aau.dk/da/publications/547d3b84-5a5b-4882-947d-67ad863246d1
Autor:
Cinzia Tesauro, Birgitta R. Knudsen, Pavel Gromov, Rikke Frøhlich, Jens Uldum Erlandsen, Magnus Stougaard, Irina Gromova, Anni H. Andersen, Josephine Geertsen Keller
Publikováno v:
Cancers
Volume 12
Issue 5
Cancers, Vol 12, Iss 1240, p 1240 (2020)
Tesauro, C, Keller, J G, Gromova, I, Gromov, P, Frøhlich, R, Erlandsen, J U, Andersen, A H, Stougaard, M & Knudsen, B R 2020, ' Different camptothecin sensitivities in subpopulations of colon cancer cells correlate with expression of different phospho-isoforms of topoisomerase i with different activities ', Cancers, vol. 12, no. 5, 1240 . https://doi.org/10.3390/cancers12051240
Volume 12
Issue 5
Cancers, Vol 12, Iss 1240, p 1240 (2020)
Tesauro, C, Keller, J G, Gromova, I, Gromov, P, Frøhlich, R, Erlandsen, J U, Andersen, A H, Stougaard, M & Knudsen, B R 2020, ' Different camptothecin sensitivities in subpopulations of colon cancer cells correlate with expression of different phospho-isoforms of topoisomerase i with different activities ', Cancers, vol. 12, no. 5, 1240 . https://doi.org/10.3390/cancers12051240
The heterogeneity of tumor cells and the potential existence of rare cells with reduced chemotherapeutic response is expected to play a pivotal role in the development of drug resistant cancers. Herein, we utilized the colon cancer cell lines, Caco2