Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jens T. Bukrinski"'
Autor:
Pernille Sønderby, Jens T. Bukrinski, Max Hebditch, Günther H. J. Peters, Robin A. Curtis, Pernille Harris
Publikováno v:
ACS Omega, Vol 3, Iss 11, Pp 16105-16117 (2018)
Externí odkaz:
https://doaj.org/article/53142283614a46ada5a0a30ec1b960b9
Publikováno v:
Edwards, J M, Harris, P, Bukrinski, J T & Golovanov, A P 2019, ' Use of 19F Differential Labelling for the Simultaneous Detection and Monitoring of Three Individual Proteins in a Serum Environment ', ChemPlusChem, vol. 84, no. 5, pp. 443-446 . https://doi.org/10.1002/cplu.201900110
Protein behavior in complex mixtures, such as biological fluids, is often modeled by simplified buffer systems in solution. Here we have used the recently described differential 19 F labelling approach (with NMR detection) to monitor and compare the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb75349ba6e59d5bbfeca5b56c98d1e
https://doi.org/10.1002/cplu.201900110
https://doi.org/10.1002/cplu.201900110
Autor:
Pernille Sønderby, Jesper J. Madsen, Jens T. Bukrinski, Pernille Harris, Åsmund Rinnan, Guenther H. H. J. Peters
Publikováno v:
Journal of Chemical Information and Modeling. 57:2463-2475
We have performed a benchmark to evaluate the relative success of using small-angle X-ray scattering (SAXS) data as constraints (hereafter termed SAXSconstrain) in the RosettaDock protocol (hereafter termed RosettaDockSAXS). For this purpose, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e1de118dd7f6ce6752f88bf86dd039
https://doi.org/10.1021/acs.jcim.6b00789
https://doi.org/10.1021/acs.jcim.6b00789
Autor:
Birgitte Andersen, Jens T. Bukrinski, Pernille Harris, Filipa Antunes, Esben G. W. Schmidt, Pernille Sønderby, Guenther H. H. J. Peters
Publikováno v:
Bukrinski, J T, Sønderby, P, Antunes, F, Andersen, B, Schmidt, E G W, Peters, G H J & Harris, P 2017, ' Glucagon-like Peptide 1 Conjugated to Recombinant Human Serum Albumin Variants with Modified Neonatal Fc Receptor Binding Properties. Impact on Molecular Structure and Half-Life ', Biochemistry, vol. 56, no. 36, pp. 4860-4870 . https://doi.org/10.1021/acs.biochem.7b00492
Glucagon-like peptide 1 (GLP-1) is a small incretin hormone stimulated by food intake, resulting in an amplification of the insulin response. Though GLP-1 is interesting as a drug candidate for the treatment of type 2 diabetes mellitus, its short pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9298496e875b2de64e42e9206d31d837
https://doi.org/10.1021/acs.biochem.7b00492
https://doi.org/10.1021/acs.biochem.7b00492
Autor:
Christian Grundahl Frankær, Christopher A. G. Söderberg, Günther H.J. Peters, Ana Labrador, Pernille Sønderby, Jens T. Bukrinski, Tomás S. Plivelic, Pernille Harris
Publikováno v:
Sønderby, P, Söderberg, C, Frankær, C G, Peters, G H J, Bukrinski, J T, Labrador, A, Plivelic, T S & Harris, P 2020, ' Concentrated protein solutions investigated using acoustic levitation and small-angle X-ray scattering ', Journal of Synchrotron Radiation, vol. 27, no. 2, pp. 396-404 . https://doi.org/10.1107/s1600577519016977
An acoustically levitated droplet has been used to collect synchrotron SAXS data on human serum albumin protein solutions up to a protein concentration of 400 mg ml−1. A careful selection of experiments allows for fast data collection of a large am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7cc70d192264fd4026630db19c2d68
https://pubmed.ncbi.nlm.nih.gov/32153278
https://pubmed.ncbi.nlm.nih.gov/32153278
Publikováno v:
ChemPlusChem. 84(5)
Protein behavior in complex mixtures, such as biological fluids, is often modeled by simplified buffer systems in solution. Here we have used the recently described differential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b456e9b79b65ff8055a110182695362
https://pubmed.ncbi.nlm.nih.gov/31943902
https://pubmed.ncbi.nlm.nih.gov/31943902
Autor:
Line A. Ryberg, Günther H.J. Peters, Jens T. Bukrinski, Fabian Barrientos, Pernille Sønderby, Pernille Harris
Publikováno v:
Ryberg, L A, Sønderby, P, Barrientos, F, Bukrinski, J T, Peters, G H J & Harris, P 2019, ' Solution structures of long-acting insulin analogues and their complexes with albumin ', Acta crystallographica Section D: Structural biology, vol. 75, no. 3, pp. 272-282 . https://doi.org/10.1107/S2059798318017552
The lipidation of peptide drugs is one strategy to obtain extended half-lives, enabling once-daily or even less frequent injections for patients. The half-life extension results from a combination of self-association and association with human serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddd178fda9999d3f306a251c6374b8c
https://pubmed.ncbi.nlm.nih.gov/30950398
https://pubmed.ncbi.nlm.nih.gov/30950398
Autor:
Anne M. Scharff-Poulsen, Maria Northved Elf-Lind, Pernille Sønderby, Pernille Harris, Günther H.J. Peters, Tine Maja Frederiksen, Line A. Ryberg, Jens T. Bukrinski
Publikováno v:
Frederiksen, T M, Sønderby, P, Ryberg, LA, Harris, P, Bukrinski, JT, Scharff-Poulsen, AM, Elf-Lind, M N & Peters, G H J 2015, ' Oligomerization of a Glucagon-like Peptide 1 Analog: Bridging Experiment and Simulations ', Biophysical Journal, vol. 109, no. 6, pp. 1202-1213 . https://doi.org/10.1016/j.bpj.2015.07.051
The glucagon-like peptide 1 (GLP-1) analog, liraglutide, is a GLP-1 agonist and is used in the treatment of type-2 diabetes mellitus and obesity. From a pharmaceutical perspective, it is important to know the oligomerization state of liraglutide with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21dd0a5e54c887032027e6a5de6114d4
https://doi.org/10.1016/j.bpj.2015.07.051
https://doi.org/10.1016/j.bpj.2015.07.051
Autor:
Ramona Valentina Mateiu, Jens T. Bukrinski, Pernille Harris, Christian Grundahl Frankær, Maria Blanner Bang, Minna Groenning, Pernille Sønderby
Publikováno v:
Frankær, C G, Sønderby, P, Bang, M B, Mateiu, R V, Groenning, M, Bukrinski, J & Harris, P 2017, ' Insulin fibrillation: The influence and coordination of Zn 2+ ', Journal of Structural Biology, vol. 199, no. 1, pp. 27-38 . https://doi.org/10.1016/j.jsb.2017.05.006
Frankær, C G, Sønderby, P, Bang, M B, Mateiu, R V, Groenning, M, Bukrinski, J & Harris, P 2017, ' Insulin fibrillation : The influence and coordination of Zn 2+ ', Journal of Structural Biology, vol. 199, no. 1, pp. 27-38 . https://doi.org/10.1016/j.jsb.2017.05.006
Frankær, C G, Sønderby, P, Bang, M B, Mateiu, R V, Groenning, M, Bukrinski, J & Harris, P 2017, ' Insulin fibrillation : The influence and coordination of Zn 2+ ', Journal of Structural Biology, vol. 199, no. 1, pp. 27-38 . https://doi.org/10.1016/j.jsb.2017.05.006
Protein amyloid fibrillation is obtaining much focus because it is connected with amyloid-related human diseases such as Alzheimer's disease, diabetes mellitus type 2, or Parkinson's disease. The influence of metal ions on the fibrillation process an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cac2a7fede134b9382dd71461126a7
https://orbit.dtu.dk/en/publications/c9bca6a3-5f23-488c-9f91-57dc8215c5e5
https://orbit.dtu.dk/en/publications/c9bca6a3-5f23-488c-9f91-57dc8215c5e5
Autor:
Kenneth A. Howard, Jason Cameron, Jesper Wengel, Michael Lykke Hvam, Malgorzata M. Pakula, Frederik Dagnæs-Hansen, Jens T. Bukrinski, Birgitte M. Malle, Ulrich Kragh-Hansen, Konrad Bienk
Publikováno v:
Bienk, K, Hvam, M L, Pakula, M M, Dagnæs-Hansen, F, Wengel, J, Malle, B M, Kragh-Hansen, U, Cameron, J, Bukrinski, J T & Howard, K A 2016, ' An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing ', Journal of Controlled Release, vol. 232, pp. 143-151 . https://doi.org/10.1016/j.jconrel.2016.04.013
Bienk, K, Hvam, M L, Pakula, M M, Dagnæs-Hansen, F, Wengel, J, Malle, B M, Kragh-Hansen, U, Cameron, J, Bukrinski, J T & Howard, K 2016, ' An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing ', Journal of Controlled Release, vol. 232, pp. 143-151 . https://doi.org/10.1016/j.jconrel.2016.04.013
Bienk, K, Hvam, M L, Pakula, M M, Dagnæs-Hansen, F, Wengel, J, Malle, B M, Kragh-Hansen, U, Cameron, J, Bukrinski, J T & Howard, K 2016, ' An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing ', Journal of Controlled Release, vol. 232, pp. 143-151 . https://doi.org/10.1016/j.jconrel.2016.04.013
Major challenges for the clinical translation of small interfering RNA (siRNA) include overcoming the poor plasma half-life, site-specific delivery and modulation of gene silencing. In this work, we exploit the intrinsic transport properties of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235f8993dad1036f02d85cab08ee1bd7
https://pubmed.ncbi.nlm.nih.gov/27084489
https://pubmed.ncbi.nlm.nih.gov/27084489