Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Jens Sydor"'
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2020 White Paper on Recent Issues in Bioanalysis: BMV of Hybrid Assays, Acoustic MS, HRMS, Data Integrity, Endogenous Compounds, Microsampling and Microbiome (Part 1 – Recommendations on Industry/Regulators Consensus on BMV of Biotherapeutics by LCMS, Advanced Application in Hybrid Assays, Regulatory Challenges in Mass Spec, Innovation in Small Molecules, Peptides and Oligos)
Autor: Luca Ferrari, Wenkui Li, Christopher P. Evans, Lieve Dillen, Noah Post, Jens Sydor, Jinhui Zhang, Susan Stojdl, Boris Gorovits, Jason Boer, Anita Lee, Mark G. Qian, Natasha Savoie, Kevin P. Bateman, Brian Dean, Allena J. Ji, Jiang Wu, Amanda Wilson, Michael H. Buonarati, Jian Wang, Gustavo Mendes Lima Santos, Daniel S Spellman, Hendrik Neubert, Hui Zhang, Scott G. Summerfield, Eric Yang, Nilufer Tampal, Parya Nouri, Christopher J Beaver, Anna Edmison, Christine Fandozzi, Troy Voelker, Jenny Zhang, Fabio Garofolo, Michael McGuinness, Sam Haidar, Bill Mylott, Stephen Vinter, Arindam Dasgupta, Patrick Faustino, Daniela Fraier, Wenying Jian, Tahseen Mirza, Sune Sporring, Diaa Shakleya, Timothy V Olah, Eric Woolf, Stephen C. Alley, Nicola Hughes, Suman Dandamudi, Hongbin Yu, Phillip Sundman, Rebecca Elliott, Lina Luo, Jan Welink
Publikováno v: Bioanalysis. 13:203-238
The 14th edition of the Workshop on Recent Issues in Bioanalysis (14th WRIB) was held virtually on June 15–29, 2020 with an attendance of over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d0f1046448eff2611c3c8337e268531
https://doi.org/10.4155/bio-2020-0324
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2
IQ consortium perspective: complementary LBA and LC–MS in protein therapeutics bioanalysis and biotransformation assessment
Autor: Mark Jairaj, Jianing Zeng, Kevin P. Bateman, Jens Sydor, Jim Glick, John F. Kellie, Surinder Kaur
Publikováno v: Bioanalysis. 12:257-270
Increasingly diverse large molecule modalities have driven the need for complex bioanalysis and biotransformation assessment involving both traditional ligand-binding assays (LBA) and more recent hybrid immunoaffinity LC–MS platforms. Given the sci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995314deebc1fde3fad5aca975fb0167
https://doi.org/10.4155/bio-2019-0279
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3
Recommendations for singlet-based approach in ligand binding assays: an IQ Consortium perspective
Autor: LaKenya Williams, Manuela Braun, Douglas Donaldson, Mark G. Qian, Carol Gleason, Tobias Haslberger, Boris Gorovits, Ling He, Jorge Quiroz, Enaksha R Wickremsinhe, David Christopher, Catherine L Brockus, Jens Sydor, Renuka Pillutla
Publikováno v: Bioanalysis. 12(12)
Historically, ligand-binding assays for pharmacokinetic samples employed duplicate rather than singlet-based analysis. Herein, the Translational and absorption, distribution, metabolism and excretion (ADME) Sciences Leadership Group of the Internatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7211183da8ef65939e4da8e61b76e357
https://pubmed.ncbi.nlm.nih.gov/32558588
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4
2018 White Paper on Recent Issues in Bioanalysis: ‘A global bioanalytical community perspective on last decade of incurred samples reanalysis (ISR)’ (Part 1 – small molecule regulated bioanalysis, small molecule biomarkers, peptides & oligonucleotide bioanalysis)
Autor: Charles S Hottenstein, Seongeun Julia Cho, Dina Goykhman, Daniela Verthelyi, Jens Sydor, Natasha Savoie, Steven P. Piccoli, Stephanie Fraser, Alex Bulychev, Elana Cherry, Yan Zhang, Anna Edmison, Ingo Röhl, Daniela Fraier, Lieve Dillen, Fabio Garofolo, Yoshiro Saito, Michael H. Buonarati, Adrien Musuku, Timothy Sangster, Barry R Jones, Eric Yang, Ragu Ramanathan, Tate Owen, Nico C van de Merbel, Anton I. Rosenbaum, Christopher Stebbins, Allena J. Ji, Daniel A. Norris, Akiko Ishii-Watabe, Rachel Green, Sean Kassim, Emma Whale, Amanda Wilson, Lina Luo, Neil Henderson, Christopher A. James, Sam Haidar, Alexander Behling, Nicola Hughes, Yuanxin Xu, Scott G. Summerfield, Isabelle Cludts, Stephen Vinter, Tom Verhaeghe, Gustavo Mendes Lima Santos, Robert Dodge, Eric Woolf, Mark Ma, Jan Welink, Kirk Brown, Uma Kavita, Hyun Gyung Jang
Publikováno v: Bioanalysis. 10:1781-1801
The 2018 12th Workshop on Recent Issues in Bioanalysis (12th WRIB) took place in Philadelphia, PA, USA on April 9–13, 2018 with an attendance of over 900 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, cont
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8d073b6bbc20524afacbc35eb80548f
https://doi.org/10.4155/bio-2018-0268
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5
Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
Autor: Volker Fischer, Olga Kavetskaia, Jens Sydor, Bruce W. Surber, Anthony J. Lee, Sonia M. de Morais, Rajeev M. Menon, Junli Ma, Jianwei Shen, Michael Serby, Prajakta S. Badri
Publikováno v: Drug Metabolism and Disposition. 44:1148-1157
Ombitasvir (also known as ABT-267) is a potent inhibitor of hepatitis C virus (HCV) nonstructural protein 5A (NS5A), which has been developed in combination with paritaprevir/ritonavir and dasabuvir in a three direct-acting antiviral oral regimens fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a788c77672d9dd09e8c905cc749a880a
https://doi.org/10.1124/dmd.115.067496
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6
Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors
Autor: Anil Vasudevan, Ana Lucia Relo, Irini Akritopoulou-Zanze, Hongyu Zhao, Mario Mezler, Carolin Hoft, Willi Amberg, Frauke Pohlki, Ying Wang, Yi-Yin Ku, Justin D. Dietrich, Michael Ochse, Yanbin Lao, Huan-Qiu Li, Steven M. Hannick, Jason T. Brewer, Berthold Behl, Jens Sydor, Udo Lange, Wilfried Hornberger
Publikováno v: Journal of medicinal chemistry. 61(17)
The glycine transporter 1 (GlyT1) has emerged as a key novel target for the treatment of schizophrenia. Herein, we report the synthesis and biological evaluation of aminotetralines and aminochromanes as novel classes of competitive GlyT1 inhibitors.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ef701eae6cddb134d20a7a01fca9f0
https://pubmed.ncbi.nlm.nih.gov/30080045
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7
De Novo Design, Synthesis, and Biological Evaluation of 3,4-Disubstituted Pyrrolidine Sulfonamides as Potent and Selective Glycine Transporter 1 Competitive Inhibitors
Autor: Udo Lange, Yanbin Lao, Wilfried Hornberger, Frauke Pohlki, Jens Sydor, Mario Mezler, Jason T. Brewer, Stevan W. Djuric, Berthold Behl, Irini Akritopoulou-Zanze, Justin D. Dietrich, Ana Lucia Relo, Hongyu Zhao, Carolin Hoft, Huan-Qiu Li, Ying Wang, Anil Vasudevan, Willi Amberg
Publikováno v: Journal of medicinal chemistry. 61(17)
The development of glycine transporter 1 (GlyT1) inhibitors may offer putative treatments for schizophrenia and other disorders associated with hypofunction of the glutaminergic N-methyl-d-aspartate (NMDA) receptor. Herein, we describe the synthesis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1cbd37b4fe43579515c610b80749e6
https://pubmed.ncbi.nlm.nih.gov/29969029
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8
Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases
Autor: Masanori Tachikawa, Yasuo Uchida, Dominik Gartzke, Gert Fricker, Tetsuya Terasaki, Yutaro Hoshi, Jens Sydor, Loic Laplanche, Jürgen Delzer
Publikováno v: Pharmaceutical Research. 32:2060-2071
To investigate whether it is possible to specifically suppress the expression and function of endogenous canine P-glycoprotein (cPgp) in Madin-Darby canine kidney type II cells (MDCKII) transfected with hPGP and breast cancer resistance protein (hBCR
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1d7bffd528bb97ba89e7ffbf179647
https://doi.org/10.1007/s11095-014-1599-5
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