Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jens Schewitz"'
Autor:
Petra Gfrörer, U. Götz, Jens Schewitz, Klaus Pusecker, Klaus Albert, Ernst Bayer, Li-Hong Tseng
Publikováno v:
Chromatographia. 50:333-337
Coupling of capillary electrophoresis (CE) with nuclear magnetic resonance (NMR) spectroscopy has been achieved by use of a recently developed capillary NMR interface. The technique has been used for the analysis of synthetic nucleic acids. A crude a
Publikováno v:
Analytical Chemistry. 71:315A-321A
Improved sensitivity, deuterated solvents, and less sample make this approach feasible for many applications.
Publikováno v:
Analytical Chemistry. 70:3280-3285
A novel capillary NMR coupling configuration, which offers the possibility of combining capillary zone electrophoresis (CZE), capillary HPLC (CHPLC), and for the first time capillary electrochromatography (CEC) with nuclear magnetic resonance (NMR),
Publikováno v:
Analytical Chemistry. 70:2197-2204
Based on the application of cationic polystyrene nanoparticles, a novel method for solid-phase extraction of phosphorothioate oligonucleotides from human plasma has been developed. A high binding affinity, which is required for an effective isolation
Publikováno v:
Zeitschrift für Naturforschung B. 52:110-116
Sulphurization is a crucial step during synthesis of phosphorothioate oligonucleotides. Insufficient reaction leads to inhomogeneous products with phosphodiester defects and subsequently to destabilization of the oligomers in biological media. To ach
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 81(2)
The pharmaceutical industry is encouraged within Quality by Design (QbD) to apply science-based manufacturing principles to assure quality not only of new but also of existing processes. This paper presents how QbD principles can be applied to an exi
Autor:
Klaus Pusecker, Jens Schewitz, Petra Gfrörer, Li-Hong Tseng, Klaus Albert, Ernst Bayer, Ian D. Wilson, Nigel J. Bailey, Graeme B. Scarfe, Jeremy K. Nicholson, John C. Lindon
Publikováno v:
Analytical Communications. 35:213-215
Direct NMR spectroscopic detection on-flow to capillary electrophoresis (CE) or capillary electrochromatography (CEC) was applied to the separation of metabolites of paracetamol from an extract of human urine. The detection and characterisation of th
Publikováno v:
Electrophoresis. 20(1)
Coupling of gradient capillary electrochromatography (gradient CEC) and capillary zone electrophoresis (CZE) with nuclear magnetic resonance spectroscopy (NMR) was performed using a recently developed capillary NMR interface. This technique was appli
Publikováno v:
Analytical biochemistry. 262(2)
Based on a novel method for solid-phase extraction using cationic polystyrene nanoparticles, the suitability of the extraction procedure for quantitation of terminally and backbone-modified antisense oligonucleotides was investigated. Extractions wer