Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jens Ruschmann"'
Autor:
Ping Xiang, Wei Wei, Nicole Hofs, Jack Clemans-Gibbon, Tobias Maetzig, Courteney K. Lai, Ishpreet Dhillon, Christopher May, Jens Ruschmann, Edith Schneider, Patricia Rosten, Kaiji Hu, Florian Kuchenbauer, Pamela A. Hoodless, R. Keith Humphries
Publikováno v:
Blood Advances, Vol 1, Iss 24, Pp 2225-2235 (2017)
Abstract: Myeloid ecotropic viral integration site 1 (MEIS1), a HOX transcription cofactor, is a critical regulator of normal hematopoiesis, and its overexpression is implicated in a wide range of leukemias. Using the clustered regularly interspaced
Externí odkaz:
https://doaj.org/article/177ee9c1a2934b1bb4877ae28a97a7d0
Autor:
Tobias Maetzig, Jens Ruschmann, Lea Sanchez Milde, Courteney K. Lai, Niklas von Krosigk, R. Keith Humphries
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 54-65 (2017)
Tracking the behavior of leukemic samples both in vitro and in vivo plays an increasingly large role in efforts to better understand the leukemogenic processes and the effects of potential new therapies. Such work can be accelerated and made more eff
Externí odkaz:
https://doaj.org/article/6b595f88b78a4bd8ab97383d7c8c50df
Autor:
Edith Schneider, Anna Staffas, Linda Röhner, Erik D. Malmberg, Arghavan Ashouri, Kathrin Krowiorz, Nicole Pochert, Christina Miller, Stella Yuan Wei, Laleh Arabanian, Christian Buske, Hartmut Döhner, Lars Bullinger, Linda Fogelstrand, Michael Heuser, Konstanze Döhner, Ping Xiang, Jens Ruschmann, Oleh I. Petriv, Alireza Heravi-Moussavi, Carl L. Hansen, Martin Hirst, R. Keith Humphries, Arefeh Rouhi, Lars Palmqvist, Florian Kuchenbauer
Publikováno v:
Haematologica, Vol 103, Iss 2 (2018)
Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155
Externí odkaz:
https://doaj.org/article/87401d72d1534be9b48a6f1e53390dbc
Autor:
Katharina Rothe, Artem Babaian, Keith Keith Humphries, Jonathan Zeng, Xiaoyan Jiang, Min Chen, Donna L. Forrest, Hanyang Lin, Oleh Petriv, Inanc Birol, Connie J. Eaves, Jens Ruschmann, Tobias Maetzig, Ryan R. Brinkman, David J.H.F. Knapp, Naoto Nakamichi, Kieran O'Neill, Carl L. Hansen, Ryan Yen, Andrew Wu
Publikováno v:
Blood
Overcoming drug resistance and targeting cancer stem cells remain challenges for curative cancer treatment. To investigate the role of microRNAs (miRNAs) in regulating drug resistance and leukemic stem cell (LSC) fate, we performed global transcripto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244fcbe5e7d9ca676c08de606117ab56
https://doi.org/10.1182/blood.2019003636
https://doi.org/10.1182/blood.2019003636
Autor:
Oleh Petriv, Jens Ruschmann, Edith Schneider, Lars Palmqvist, Kathrin Krowiorz, Anna Staffas, Erik Delsing Malmberg, Carl L. Hansen, Hartmut Döhner, Arefeh Rouhi, Florian Kuchenbauer, Martin Hirst, Arghavan Ashouri, Ping Xiang, Michael Heuser, Konstanze Döhner, Stella Yuan Wei, Lars Bullinger, Christina Miller, Linda Röhner, Nicole Pochert, R. Keith Humphries, Laleh S. Arabanian, Alireza Heravi-Moussavi, Christian Buske, Linda Fogelstrand
Publikováno v:
Haematologica
Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e0e72d1b0ec5d74e7282eea9068a83
http://europepmc.org/articles/PMC5792269
http://europepmc.org/articles/PMC5792269
Autor:
Kaiji Hu, Patricia Rosten, Florian Kuchenbauer, R. Keith Humphries, Ishpreet Dhillon, Pamela A. Hoodless, Edith Schneider, Wei Wei, Christopher May, Nicole Hofs, Courteney Lai, Jens Ruschmann, Jack Clemans-Gibbon, Tobias Maetzig, Ping Xiang
Publikováno v:
Blood Advances. 1:2225-2235
Myeloid ecotropic viral integration site 1 (MEIS1), a HOX transcription cofactor, is a critical regulator of normal hematopoiesis, and its overexpression is implicated in a wide range of leukemias. Using the clustered regularly interspaced short pali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601f23dfb8c39834e065070d487b6e7f
https://doi.org/10.1182/bloodadvances.2017010355
https://doi.org/10.1182/bloodadvances.2017010355
Autor:
Lea Sanchez Milde, Jens Ruschmann, R. Keith Humphries, Courteney Lai, Tobias Maetzig, Niklas von Krosigk
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 54-65 (2017)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Tracking the behavior of leukemic samples both in vitro and in vivo plays an increasingly large role in efforts to better understand the leukemogenic processes and the effects of potential new therapies. Such work can be accelerated and made more eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce63c312066a9c254c46782f0ac1d40
http://www.sciencedirect.com/science/article/pii/S2329050117300724
http://www.sciencedirect.com/science/article/pii/S2329050117300724
Autor:
Simon Leierseder, Arefeh Rouhi, Andrew L Muranyi, Stefan Engelhardt, Francesco Boccalatte, Jens Ruschmann, Daniel T. Starczynowski, Bob Argiropoulos, Aly Karsan, Christian Buske, Mojca Jongen-Lavrencic, Michael Heuser, Tiziana Plati, R. Keith Humphries, Hartmut Döhner, Bernhard Gentner, Nicole Pochert, Tobias Berg, Florian Kuchenbauer, Milijana mirkovic-Hosle, Su Ming Sun, Sarah M Mah, Donna E. Hogge, Luigi Naldini, Fernando D. Camargo
Publikováno v:
Experimental Hematology, 43(10), 858-868. Elsevier Inc.
A precise understanding of the role of miR-223 in human hematopoiesis and in the pathogenesis of acute myeloid leukemia (AML) is still lacking. By measuring miR-223 expression in blasts from 115 AML patients, we found significantly higher miR-223 lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e351039c1fefe77ab81901c3f001189
https://pure.eur.nl/en/publications/c4bed309-c0a0-4853-a85f-dcd66fc3f4a0
https://pure.eur.nl/en/publications/c4bed309-c0a0-4853-a85f-dcd66fc3f4a0
Autor:
Christopher May, Patricia Rosten, Anton Selich, Tobias Maetzig, Jens Ruschmann, Niklas von Krosigk, Michael Rothe, Axel Schambach, R. Keith Humphries, Mor Ngom, Gudmundur L. Norddahl, Lea Sanchez Milde, Suzan Imren, Courteney Lai, Ishpreet Dhillon
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 25(3)
Retroviral integration site analysis and barcoding have been instrumental for multiplex clonal fate mapping, although their use imposes an inherent delay between sample acquisition and data analysis. Monitoring of multiple cell populations in real ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1b002effe6dda14e241eaa0691a245
https://pubmed.ncbi.nlm.nih.gov/28253481
https://pubmed.ncbi.nlm.nih.gov/28253481
Autor:
Yuzhuo Wang, Connie J. Eaves, Lars Bullinger, Michael Heuser, Akira Watahiki, Florian Kuchenbauer, R. Keith Humphries, Jürgen Krauter, Christian Buske, Samuel Aparicio, Bob Argiropoulos, Hartmut Döhner, Lars Palmqvist, Tobias Berg, Daniel T. Starczynowski, Aly Karsan, Arefeh Rouhi, Ryan D. Morin, Andrew McPherson, Marco A. Marra, Konstanze Döhner, Fernando D. Camargo, Jens Ruschmann, Sarah M Mah, Arnold Ganser, David Lai
Publikováno v:
Blood. 118:3350-3358
Processing of pre-miRNA through Dicer1 generates an miRNA duplex that consists of an miRNA and miRNA* strand. Despite the general view that miRNA*s have no functional role, we further investigated miRNA* species in 10 deep-sequencing libraries from m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbcd0309d505c08f9a978e8f52690f6
https://doi.org/10.1182/blood-2010-10-312454
https://doi.org/10.1182/blood-2010-10-312454