Zobrazeno 1 - 10
of 346
pro vyhledávání: '"Jens Rettig"'
Autor:
Hsin-Fang Chang, Claudia Schirra, Momchil Ninov, Ulrike Hahn, Keerthana Ravichandran, Elmar Krause, Ute Becherer, Štefan Bálint, Maria Harkiolaki, Henning Urlaub, Salvatore Valitutti, Cosima T. Baldari, Michael L. Dustin, Reinhard Jahn, Jens Rettig
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cytotoxic T cells have specialised granules that are important for mediating their killing function. Here the authors characterise two types of cytotoxic granules and indicate different functions and temporal release of mediators at the immunological
Externí odkaz:
https://doaj.org/article/31a8c24e301a4df68584d46846ad161c
Autor:
Angelina Staudt, Olga Ratai, Aicha Bouzouina, Claudia Fecher-Trost, Ahmed Shaaban, Hawraa Bzeih, Alexander Horn, Ali H. Shaib, Margarete Klose, Veit Flockerzi, Marcel A. Lauterbach, Jens Rettig, Ute Becherer
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Both paralogs of the calcium-dependent activator protein for secretion (CAPS) are required for exocytosis of synaptic vesicles (SVs) and large dense core vesicles (LDCVs). Despite approximately 80% sequence identity, CAPS1 and CAPS2 have distinct fun
Externí odkaz:
https://doaj.org/article/5286869c7a7e4edfb1a509880282ac20
Autor:
Praneeth Chitirala, Hsin-Fang Chang, Paloma Martzloff, Christiane Harenberg, Keerthana Ravichandran, Midhat H Abdulreda, Per-Olof Berggren, Elmar Krause, Claudia Schirra, Trese Leinders-Zufall, Fritz Benseler, Nils Brose, Jens Rettig
Publikováno v:
eLife, Vol 9 (2020)
Understanding T cell function in vivo is of key importance for basic and translational immunology alike. To study T cells in vivo, we developed a new knock-in mouse line, which expresses a fusion protein of granzyme B, a key component of cytotoxic gr
Externí odkaz:
https://doaj.org/article/b37eccad99c04025abdd7fd3715a33f8
Autor:
Donatella Galgano, Tayebeh Soheili, Matthias Voss, Lamberto Torralba-Raga, Bianca Tesi, Frank Cichocki, Isabelle Andre, Jens Rettig, Marina Cavazzana, Yenan Bryceson
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Autosomal recessive mutations in genes required for cytotoxicity are causative of a life-threatening, early-onset hyperinflammatory syndrome termed familial hemophagocytic lymphohistiocytosis (FHL). Mutations in UNC13D cause FHL type 3. UNC13D encode
Externí odkaz:
https://doaj.org/article/69f9bb01c1a646f79fb2cac91f012148
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Granules of cytotoxic T lymphocytes (CTL) are derived from the lysosomal compartment. Synaptotagmin7 (Syt7) appears to be the calcium sensor triggering fusion of lysosomes in fibroblasts. Syt7 has been proposed to control cytotoxic granule (CG) fusio
Externí odkaz:
https://doaj.org/article/9b3e71eb6fd846eaa1813bf7fc6b8893
Autor:
Marie-Christine Klein, Katharina Zimmermann, Stefan Schorr, Martina Landini, Patrick A. W. Klemens, Jacqueline Altensell, Martin Jung, Elmar Krause, Duy Nguyen, Volkhard Helms, Jens Rettig, Claudia Fecher-Trost, Adolfo Cavalié, Markus Hoth, Ivan Bogeski, H. Ekkehard Neuhaus, Richard Zimmermann, Sven Lang, Ilka Haferkamp
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Endoplasmic reticulum (ER) functioning requires a constant supply of ATP, but the exchanger required for ATP uptake into the ER is unknown. Here, the authors report that SLC35B1, here named AXER, or ATP/ADP exchanger into the ER, can transport ATP in
Externí odkaz:
https://doaj.org/article/ac526f2764c44504b8828f5d643e6d8d
Autor:
Praneeth Chitirala, Keerthana Ravichandran, Donatella Galgano, Marwa Sleiman, Elmar Krause, Yenan T. Bryceson, Jens Rettig
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Cytotoxic T lymphocytes kill infected or malignant cells through the directed release of cytotoxic substances at the site of target cell contact, the immunological synapse. While genetic association studies of genes predisposing to early-onset life-t
Externí odkaz:
https://doaj.org/article/61122c8ee1454381ac65f98e7f08cf8e
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 13, p 4660 (2020)
Cytotoxic T lymphocytes (CTL) are an essential part of our immune system by killing infected and malignant cells. To fully understand this process, it is necessary to study CTL function in the physiological setting of a living organism to account for
Externí odkaz:
https://doaj.org/article/d157b9f1f3ad45c5a1f00fe33cc9c8c2
Autor:
Michael Estl, Pascal Blatt, Xuemei Li, Ute Becherer, Hsin-Fang Chang, Jens Rettig, Varsha Pattu
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2475 (2020)
Cytotoxic T lymphocytes (CTL) are key players of the adaptive immune system that target tumors and infected cells. A central step to that is the formation of a cell–cell contact zone between the CTL and its target called an immune synapse (IS). Her
Externí odkaz:
https://doaj.org/article/41e42db0c00f4186903c3e020fe54d3a
Autor:
Ali H. Shaib, Angelina Staudt, Ali Harb, Margarete Klose, Ahmed Shaaban, Claudia Schirra, Ralf Mohrmann, Jens Rettig, Ute Becherer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
The two paralogs of the calcium-dependent activator protein for secretion (CAPS) are priming factors for synaptic vesicles (SVs) and neuropeptide containing large dense-core vesicles (LDCVs). Yet, it is unclear whether CAPS1 and CAPS2 regulate exocyt
Externí odkaz:
https://doaj.org/article/e4b7907f3a544aca8eac22eb538d917e