Zobrazeno 1 - 10
of 435
pro vyhledávání: '"Jens R, Nyengaard"'
Autor:
Monalisa Padhee, Mitchell C. Lock, I. Caroline McMillen, Song Zhang, Kimberley J. Botting, Jens R. Nyengaard, Severence M. MacLaughlin, David O. Kleemann, Simon K. Walker, Jennifer M. Kelly, Skye R. Rudiger, Janna L. Morrison
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 5, Iss , Pp 100039- (2023)
Embryo culture with and without human serum supplementation, previously common practice in assisted reproductive technologies (ARTs), have been associated with increased heart weight in early and late gestation in the sheep fetus. The present study a
Externí odkaz:
https://doaj.org/article/a356901f738f4c7da91f640674e584c6
Autor:
Nick Y. Larsen, Ninna Vihrs, Jesper Møller, Jon Sporring, Xueke Tan, Xixia Li, Gang Ji, Grazyna Rajkowska, Fei Sun, Jens R. Nyengaard
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Brodmann Area 46 (BA46) has long been regarded as a hotspot of disease pathology in individuals with schizophrenia (SCH) and major depressive disorder (MDD). Pyramidal neurons in layer III of the Brodmann Area 46 (BA46) project to other cort
Externí odkaz:
https://doaj.org/article/5b14b2a3b9a147ffa7231645403b8830
Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections
Autor:
Nick Y. Larsen, Xixia Li, Xueke Tan, Gang Ji, Jing Lin, Grazyna Rajkowska, Jesper Møller, Ninna Vihrs, Jon Sporring, Fei Sun, Jens R. Nyengaard
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Nick Larsen et al. developed a pipeline to collect and image serial sections from fixed human cortex, then apply deep learning to detect pyramidal cells from 3D reconstructions of these sections. Their results reiterate that cortical pyramidal cells
Externí odkaz:
https://doaj.org/article/c372f12dc5a442998736c0ade347fe0e
Autor:
Alberto Delaidelli, Mette Richner, Lixiang Jiang, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Nelson Ferreira, Jens R. Nyengaard, Christian B. Vægter, Poul H. Jensen, Ian R. Mackenzie, Poul H. Sorensen, Asad Jan
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol SNCA), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleinopathies. Several findings in experimental models
Externí odkaz:
https://doaj.org/article/4556178dc7c94ccab3861fb11cbb6d65
Autor:
Mariane H. Schleimann, Maria-Louise Kobberø, Line K. Vibholm, Kathrine Kjær, Leila B. Giron, Kathleen Busman-Sahay, Chi Ngai Chan, Michael Nekorchuk, Manuel Schmidt, Burghardt Wittig, Tine E. Damsgaard, Peter Ahlburg, Michel B. Hellfritzsch, Kaja Zuwala, Frederik H. Rothemejer, Rikke Olesen, Phillipp Schommers, Florian Klein, Harsh Dweep, Andrew Kossenkov, Jens R. Nyengaard, Jacob D. Estes, Mohamed Abdel-Mohsen, Lars Østergaard, Martin Tolstrup, Ole S. Søgaard, Paul W. Denton
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 328-340 (2019)
Background: TLR9 agonists are being developed as immunotherapy against malignancies and infections. TLR9 is primarily expressed in B cells and plasmacytoid dendritic cells (pDCs). TLR9 signalling may be critically important for B cell activity in lym
Externí odkaz:
https://doaj.org/article/6617a90ba47a4cea9fc13ade7be6bc01
Autor:
Thorsten K. Rasmussen, Páll Karlsson, Nanna B. Finnerup, Troels S. Jensen, Jens R. Nyengaard, Astrid J. Terkelsen
Publikováno v:
Rasmussen, T K, Karlsson, P, Finnerup, N B, Jensen, T S, Nyengaard, J R & Terkelsen, A J 2023, ' Functional and structural markers of peripheral microvascular autonomic neuropathy ', Muscle & Nerve, vol. 67, no. 2, pp. 146-153 . https://doi.org/10.1002/mus.27770
Introduction/Aims: Autonomic dysfunction is a common complication of small-fiber neuropathy (SFN). In this study we aimed to assess the applicability of autonomic microvascular indices as a potential marker for SFN assessment. Methods: Fifteen patien
Autor:
Christian Damsgaard, Henrik Lauridsen, Anette MD Funder, Jesper S Thomsen, Thomas Desvignes, Dane A Crossley II, Peter R Møller, Do TT Huong, Nguyen T Phuong, H William Detrich III, Annemarie Brüel, Horst Wilkens, Eric Warrant, Tobias Wang, Jens R Nyengaard, Michael Berenbrink, Mark Bayley
Publikováno v:
eLife, Vol 8 (2019)
The retina has a very high energy demand but lacks an internal blood supply in most vertebrates. Here we explore the hypothesis that oxygen diffusion limited the evolution of retinal morphology by reconstructing the evolution of retinal thickness and
Externí odkaz:
https://doaj.org/article/ef3139edd42545b8a41f468f6ce82920
Publikováno v:
Neuroscience Insights, Vol 14 (2019)
Recombinant adeno-associated virus (rAAV) vectors have emerged as the safe vehicles of choice for long-term gene transfer in mammalian nervous system. Recombinant adeno-associated virus–mediated localized gene transfer in adult nervous system follo
Externí odkaz:
https://doaj.org/article/ed44856202ed4a9b8f1c0e13bf91ae4c
Autor:
Line S. Reinert, Katarína Lopušná, Henriette Winther, Chenglong Sun, Martin K. Thomsen, Ramya Nandakumar, Trine H. Mogensen, Morten Meyer, Christian Vægter, Jens R. Nyengaard, Katherine A. Fitzgerald, Søren R. Paludan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The cGAS–STING pathway is an important immune defence pathway against viral infection, including HSV-1. Here the authors use an HSV-1 encephalitis model and show microglia are the main producers of type 1 interferons that induce antiviral activity
Externí odkaz:
https://doaj.org/article/9c9ff79ecf304100a3671a4551b19557
Autor:
Paolo Tornese, Nathalie Sala, Daniela Bonini, Tiziana Bonifacino, Luca La Via, Marco Milanese, Giulia Treccani, Mara Seguini, Alessandro Ieraci, Jessica Mingardi, Jens R. Nyengaard, Stefano Calza, Giambattista Bonanno, Gregers Wegener, Alessandro Barbon, Maurizio Popoli, Laura Musazzi
Publikováno v:
Neurobiology of Stress, Vol 10, Iss , Pp - (2019)
Depression is a debilitating mental disease, characterized by persistent low mood and anhedonia. Stress represents a major environmental risk factor for depression; the complex interaction of stress with genetic factors results in different individua
Externí odkaz:
https://doaj.org/article/2d013c98480c4f938be72adaed4c287a