Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jens Quant"'
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
Chemical structure of BI 811283: 2,3-diamino-pyrimidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b569a67ee6db1fdbb4b9b9898d09fa
https://doi.org/10.1158/1535-7163.22503072
https://doi.org/10.1158/1535-7163.22503072
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
Supplementary Table S1: Statistics of data collection and processing of AuroraB/INCENP in complex with BI 847325; Supplementary Table S2: Statistics of data collection and processing of MEK1 in complex with BI 847325; Supplementary Table S3: Statisti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a674f9a24129289384fc2594456c5203
https://doi.org/10.1158/1535-7163.22503057
https://doi.org/10.1158/1535-7163.22503057
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
(A), MEK1 and phospho-MEK1/2; (B) ERK1/2 and phospho-ERK1/2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364401e0cf33e13f4ddf75ae3b69dd1f
https://doi.org/10.1158/1535-7163.22503066.v1
https://doi.org/10.1158/1535-7163.22503066.v1
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
(A), MEK1 and phospho-MEK1/2; (B) ERK1/2 and phospho-ERK1/2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea465e8bb386c7526ee890a39c10857
https://doi.org/10.1158/1535-7163.22503069.v1
https://doi.org/10.1158/1535-7163.22503069.v1
Autor:
Norbert Kraut, Günther R. Adolf, Eric Haaksma, Andreas Zoephel, Stephan K. Zahn, Heather Tye, Matthias Treu, Otmar Schaaf, Alexander Savchenko, Jens Quant, Dirk Kessler, Marco H. Hofmann, Pilar Garin-Chesa, Joshua Apgar, Michael P. Sanderson
Supplementary Materials and Methods, Tables S1 through S3 and Figures S1 and S2 - Supplementary Materials and Methods: The sources, application and dilution of the antibodies used for Western blotting (WB) and immunohistochemical (IHC) analyses in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb6189c7b8fb2d741fdf8290172943c
https://doi.org/10.1158/1535-7163.22503943
https://doi.org/10.1158/1535-7163.22503943
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
(A), MEK1 and phospho-MEK1/2; (B) ERK1/2 and phospho-ERK1/2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7900c0b469b7183181eea3504d39d1
https://doi.org/10.1158/1535-7163.22503063
https://doi.org/10.1158/1535-7163.22503063
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
BomTac:NMRI-Foxn1nu mice bearing human MIAPaCa-2 tumors were treated with vehicle, BI 847325 at 10 mg/kg daily p.o., AZD6244 at 25 mg/kg twice daily p.o., GSK 1120212 at 0.25 mg/kg twice daily p.o. Data is plotted as average tumor volume with standar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7bfd5ae2616333b34e1ecb62821f3e
https://doi.org/10.1158/1535-7163.22503060.v1
https://doi.org/10.1158/1535-7163.22503060.v1
Autor:
Wolfgang J. Rettig, Armin Heckel, Jens Quant, Andreas Zoephel, Gerd Bader, Pilar Garin-Chesa, Ulrike Tontsch-Grunt, Wolfgang Sommergruber, Susanna Kautschitsch, Martin Krssak, Gerald J. Roth, Frank Hilberg
Inhibition of tumor angiogenesis through blockade of the vascular endothelial growth factor (VEGF) signaling pathway is a novel treatment modality in oncology. Preclinical findings suggest that long-term clinical outcomes may improve with blockade of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b6ea2186679c686773cc82eb8804b8
https://doi.org/10.1158/0008-5472.c.6497339
https://doi.org/10.1158/0008-5472.c.6497339
Autor:
Wolfgang J. Rettig, Armin Heckel, Jens Quant, Andreas Zoephel, Gerd Bader, Pilar Garin-Chesa, Ulrike Tontsch-Grunt, Wolfgang Sommergruber, Susanna Kautschitsch, Martin Krssak, Gerald J. Roth, Frank Hilberg
Supplementary Methods, Figure 1, Table 1 from BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc987044139262ecca31c9b8b23fd85
https://doi.org/10.1158/0008-5472.22374101.v1
https://doi.org/10.1158/0008-5472.22374101.v1
Autor:
Yvonne Scherbantin, Gerd Bader, thomas Fett, Harald Weinstabl, Sophie Mitzner, Tuncay Ciftci, Bernhard Wolkerstorfer, Jens Bruchhaus, Xiaobing Lv, Dongyang Li, Bernadette Sharps, Daniela Haering, Heribert Arnhof, Nikolai Mischerikow, Geraldine Garavel, Andreas Schrenk, Joerg Rinnenthal, Roland Kousek, Thomas Gerstberger, Guido Scholz, Stephan Karl Zahn, Paola Martinelli, Jens Quant, Renate Schnitzer, Andreas Zoephel, Darryl B. McConnell, Moriz Mayer, Dirk Kessler, Xuechun Zhang, Michelle Burkard, Mark Pearson, Karin S. Hofbauer, Alicia Du, Matthias Treu, Christoph Harrer, Yali Li, Fabio Savarese, Klaus Rumpel, Biljana Peric-Simov, Georg Dahmann, Wolfgang Sommergruber, Peter Ettmayer
Publikováno v:
Journal of Medicinal Chemistry. 62:7976-7997
Phosphoglycerate dehydrogenase (PHGDH) is known to be the rate-limiting enzyme in the serine synthesis pathway in humans. It converts glycolysis-derived 3-phosphoglycerate to 3-phosphopyruvate in a co-factor-dependent oxidation reaction. Herein, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aae2be102afb8dc581630c149133ec0d
https://doi.org/10.1021/acs.jmedchem.9b00718
https://doi.org/10.1021/acs.jmedchem.9b00718
