Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jens Pfalzgraf"'
Autor:
Jeyaprakashnarayanan Seenisamy, Frank Becker, Djordje Musil, Jörg Bomke, Jakub Gunera, Uwe Eckert, Timo Heinrich, Felix Rohdich, Kerrin Hansen, Beatrix Blume, Christian Siegl, Frank Zenke, Jens Pfalzgraf, Dieter Spuck, Ansgar Wegener, Birgitta Leuthner, Melanie Dietz, Manja Friese-Hamim
Publikováno v:
Journal of Medicinal Chemistry. 62:11119-11134
The recently disclosed next generation of reversible, selective, and potent MetAP-2 inhibitors introduced a cyclic tartronic diamide scaffold. However, the lead compound 1a suffered from enterohepatic circulation, preventing further development. Neve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::539fb7d602f3d1bbfe1d4a86e7331eb7
https://doi.org/10.1021/acs.jmedchem.9b01070
https://doi.org/10.1021/acs.jmedchem.9b01070
Autor:
Timo, Heinrich, Jeyaprakashnarayanan, Seenisamy, Frank, Becker, Beatrix, Blume, Jörg, Bomke, Melanie, Dietz, Uwe, Eckert, Manja, Friese-Hamim, Jakub, Gunera, Kerrin, Hansen, Birgitta, Leuthner, Djordje, Musil, Jens, Pfalzgraf, Felix, Rohdich, Christian, Siegl, Dieter, Spuck, Ansgar, Wegener, Frank T, Zenke
Publikováno v:
Journal of medicinal chemistry. 62(24)
The recently disclosed next generation of reversible, selective, and potent MetAP-2 inhibitors introduced a cyclic tartronic diamide scaffold. However, the lead compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b4dcbfeb991a35c29e879c5251cd665
https://pubmed.ncbi.nlm.nih.gov/31725285
https://pubmed.ncbi.nlm.nih.gov/31725285