Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Jens Peter Volkmer"'
Autor:
Mark P. Chao, Chris H. Takimoto, Dong Dong Feng, Kelly McKenna, Phung Gip, Jie Liu, Jens-Peter Volkmer, Irving L. Weissman, Ravindra Majeti
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
In recent years, immunotherapies have been clinically investigated in AML and other myeloid malignancies. While most of these are focused on stimulating the adaptive immune system (including T cell checkpoint inhibitors), several key approaches targe
Externí odkaz:
https://doaj.org/article/8638e8ad243d4633b048ad522ad22867
Autor:
Joseph C. Liao, Eben L. Rosenthal, Irving L. Weissman, Jens-Peter Volkmer, Chiyuan Amy Zhang, Kathleen E. Mach, Kelly McKenna, Robert Ertsey, Nynke S. van den Berg, Bernhard Kiss
Purpose:Near-infrared photoimmunotherapy (NIR-PIT) is a localized molecular cancer therapy combining a photosensitizer-conjugated mAb and light energy. CD47 is an innate immune checkpoint widely expressed on bladder cancer cells, but absent from lumi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd911e468c9dec0fe72fb92143ff73c
https://doi.org/10.1158/1078-0432.c.6527972.v1
https://doi.org/10.1158/1078-0432.c.6527972.v1
Autor:
Joseph C. Liao, Eben L. Rosenthal, Irving L. Weissman, Jens-Peter Volkmer, Chiyuan Amy Zhang, Kathleen E. Mach, Kelly McKenna, Robert Ertsey, Nynke S. van den Berg, Bernhard Kiss
Supplementary methods and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb465a5d37e30b5bcbf26d662fcdb69c
https://doi.org/10.1158/1078-0432.22471706.v1
https://doi.org/10.1158/1078-0432.22471706.v1
Autor:
James Chen, Lisa Johnson, Kelly McKenna, Timothy Choi, Jiaqi Duan, Dongdong Feng, Jonathan Tsai, Natalia Garcia-Martin, Kavitha Sompalli, Roy Maute, Paresh Vyas, Ravindra Majeti, Chris Takimoto, Jie Liu, Giridharan Ramsingh, Mark Chao, Jens-Peter Volkmer, Irving Weissman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a723632ee416401faf04f925a4c0ca4a
https://doi.org/10.1016/s2152-2650(22)01421-5
https://doi.org/10.1016/s2152-2650(22)01421-5
Autor:
James Chen, Lisa Johnson, Kelly McKenna, Timothy Choi, Jiaqi Duan, Dongdong Feng, Jonathan Tsai, Natalia Garcia-Martin, Kavitha Sompalli, Roy Maute, Paresh Vyas, Ravindra Majeti, Chris Takimoto, Jie Liu, Giridharan Ramsingh, Mark Chao, Jens-Peter Volkmer, Irving Weissman
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S154
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b54b404a08612dd4da5902c30f2de56b
https://doi.org/10.1016/s2152-2650(22)00940-5
https://doi.org/10.1016/s2152-2650(22)00940-5
Autor:
Mark D. Pegram, Po Yi Ho, Rosalynd Upton, Kevin S. Kao, Benyamin Rosental, Michal Caspi Tal, Mckenna Kelly Marie, Tal Raveh, Stephen B. Willingham, Dongdong Feng, Jens-Peter Volkmer, Allison Banuelos, Tanuka Biswas, Irving L. Weissman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This study demonstrates the efficacy of combining macrophage-checkpoint inhibition with tumor-specific antibodies for cancer immunotherapy. The combination of anti-CD47 (magrolimab) and anti-HER2 (trastuzumab) antibodies eliminated HER2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b86c70a3c209942c00774efc9102ada
https://doi.org/10.1073/pnas.2026849118
https://doi.org/10.1073/pnas.2026849118
Autor:
Jens-Peter Volkmer, Chiyuan Amy Zhang, Kathleen E. Mach, Eben L. Rosenthal, Bernhard Kiss, Joseph C. Liao, Nynke S. van den Berg, Mckenna Kelly Marie, Robert Ertsey, Irving L. Weissman
Publikováno v:
Clinical Cancer Research. 25:3561-3571
Purpose: Near-infrared photoimmunotherapy (NIR-PIT) is a localized molecular cancer therapy combining a photosensitizer-conjugated mAb and light energy. CD47 is an innate immune checkpoint widely expressed on bladder cancer cells, but absent from lum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148bd325301a5d704a6027fd8b254e35
https://doi.org/10.1158/1078-0432.ccr-18-3267
https://doi.org/10.1158/1078-0432.ccr-18-3267
Autor:
James Yuhtyng Chen, Lisa Johnson, Kelly Marie McKenna, Timothy S. Choi, Jiaqi Duan, Dongdong Feng, Jonathan M. Tsai, Natalia Garcia-Martin, Kavitha Sompalli, Roy Maute, Paresh Vyas, Ravindra Majeti, Chris H.M. Takimoto, Jie Liu, Giridharan Ramsingh, Mark Chao, Jens-Peter Volkmer, Irving L. Weissman
Publikováno v:
Journal of Clinical Oncology. 40:7054-7054
7054 Background: Magrolimab is a monoclonal antibody that blocks CD47, a “don’t eat me” signal expressed on cancer cells to escape immune surveillance and macrophage-mediated clearance. Prior preclinical studies have shown that CD47 is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d5133aebc755b5fb82e240beb136c9e
https://doi.org/10.1200/jco.2022.40.16_suppl.7054
https://doi.org/10.1200/jco.2022.40.16_suppl.7054
Autor:
Naval Daver, Joshua F. Zeidner, Paresh Vyas, Ming Lin, Daniel J. Lee, Joanna Van Elk, David A. Sallman, Andrew Whiteley, Rami S. Komrokji, Guillermo Garcia-Manero, Deepa Jeyakumar, Jens-Peter Volkmer, Gabriel N. Mannis, Mark P. Chao, Tiffany N. Tanaka, Adam S. Asch, Richard A. Larson, Chris H. Takimoto, Roy Louis Maute, Monzr M. Al Malki, William B. Donnellan, Wanxing Chai-Ho, Guido G. Marcucci, Suman Kambhampati
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:S290
Context: Magrolimab, an anti-CD47 antibody, induces tumor phagocytosis and eliminates leukemia stem cells. Azacitidine (AZA) synergizes with magrolimab by inducing prophagocytic “eat me” signals. Magrolimab + AZA is clinically effective in acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36c280f3cd4ef68bafb95d2d7eb8be3c
https://doi.org/10.1016/s2152-2650(21)01694-3
https://doi.org/10.1016/s2152-2650(21)01694-3
Autor:
Jie Liu, Shirley Mihardja, Irving L. Weissman, Ravindra Majeti, Jens-Peter Volkmer, Balaji Agoram, Kavitha Sompalli, Sharline Chen, Seethu Xavy, Timothy S Choi, Dongdong Feng
Publikováno v:
JCI Insight
The CD47/signal regulatory protein α (Cd47/SIRPα)interaction provides a macrophage immune checkpoint pathway that plays a critical role in cancer immune evasion across multiple cancers. Here, we report the engineering of a humanized anti-SIRPα mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47165cdac3a638bd37ce609e8658616
https://pubmed.ncbi.nlm.nih.gov/32427583
https://pubmed.ncbi.nlm.nih.gov/32427583