Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jens P. Fürste"'
Autor:
Charlotte Förster, André Eichert, Dominik Oberthür, Christian Betzel, Reinhard Geßner, Andreas Nitsche, Jens P. Fürste
Publikováno v:
Journal of Nucleic Acids, Vol 2012 (2012)
“Locked nucleic acids” (LNAs) belong to the backbone-modified nucleic acid family. The 2′-O,4′-C-methylene-β-D-ribofuranose nucleotides are used for single or multiple substitutions in RNA molecules and thereby introduce enhanced bio- and th
Externí odkaz:
https://doaj.org/article/93ee7fccbafb4a209a2d2b9c6ad3ff93
Autor:
Fred Lisdat, Claudia Gallin, Reinhard Geßner, Jens P. Fürste, Maika Rothkegel, Martin Zydek, Charlotte Förster, Zhiyang Wu
Publikováno v:
Biochemical and Biophysical Research Communications. 419:60-65
‘Locked nucleic acids’ (LNAs) are sugar modified nucleic acids containing the 2′- O -4′ C -methylene- β - d -ribofuranoses. The substitution of RNAs with LNAs leads to an enhanced thermostability. Aptamers are nucleic acids, which are select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcd45f54cbba3890eb20dbb41459de9
https://doi.org/10.1016/j.bbrc.2012.01.127
https://doi.org/10.1016/j.bbrc.2012.01.127
Autor:
Charlotte Förster, Volker A. Erdmann, Reinhard Geßner, Jens P. Fürste, Dominik Oberthuer, Christian Betzel, André Eichert
Publikováno v:
Biochemical and Biophysical Research Communications. 412:532-536
tRNAs are aminoacylated by the aminoacyl-tRNA synthetases. There are at least 20 natural amino acids, but due to the redundancy of the genetic code, 64 codons on the mRNA. Therefore, there exist tRNA isoacceptors that are aminoacylated with the same
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85854bdfca9cd3beeb0073fb7ce45c67
https://doi.org/10.1016/j.bbrc.2011.07.030
https://doi.org/10.1016/j.bbrc.2011.07.030
Autor:
Volker A. Erdmann, Jens P. Fürste, Charlotte Förster, Dominik Oberthuer, Christian Betzel, Andreas Nitsche, Jiang Gao, André Eichert, Frederick G. Quast
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 65:881-885
Locked nucleic acids (LNAs) are modified nucleic acids which contain a modified sugar such as beta-D-2'-O,4'-C methylene-bridged ribofuranose or other sugar derivatives in LNA analogues. The beta-D-2'-O,4'-C methylene ribofuranose LNAs in particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8d23f3f3e79a967221866e49a6204e
https://doi.org/10.1107/s1744309109029145
https://doi.org/10.1107/s1744309109029145
Autor:
Jens P. Fürste, Volker A. Erdmann, Charlotte Förster, André Eichert, Christian Betzel, Angela Schreiber, Markus Perbandt
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 65:98-101
The aminoacylation of tRNA is a crucial step in cellular protein biosynthesis. Recognition of the cognate tRNA by the correct aminoacyl-tRNA synthetase is ensured by tRNA identity elements. In tRNA(Arg), the identity elements consist of the anticodon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf04fb3ac49c701e602b5a03bb5dca84
https://doi.org/10.1107/s1744309108042012
https://doi.org/10.1107/s1744309108042012
Autor:
André Eichert, Charlotte Förster, Jens P. Fürste, Angela Schreiber, Christian Betzel, Volker A. Erdmann, Markus Perbandt
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 65:59-62
Interest has been focused on comparative X-ray structure analyses of different tRNA(Gly) acceptor-stem helices. tRNA(Gly)/glycyl-tRNA synthetase belongs to the so-called class II system, in which the tRNA identity elements consist of simple and uniqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebeb38a5767d14076b625504cc3c82f
https://doi.org/10.1107/s1744309108040153
https://doi.org/10.1107/s1744309108040153
Autor:
Volker A. Erdmann, Kathrin Schmidt, Jens Kurreck, Arnd B. E. Brauer, Arne Meyer, Charlotte Förster, Christian Betzel, Svenja Brode, Wojciech Rypniewski, Markus Perbandt, Jens P. Fürste
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 62:665-668
The pharmacokinetic properties of an aptamer against the tumour-marker protein tenascin-C have recently been successfully improved by the introduction of locked nucleic acids (LNAs) into the terminal stem of the aptamer. Since it is believed that thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdebf5787043ae775f08a20b2f49e2dd
https://doi.org/10.1107/s1744309106020343
https://doi.org/10.1107/s1744309106020343
Autor:
Françoise Hinnen, Bertrand Kuhnast, Raphaël Boisgard, Frédéric Dollé, Jens P. Fürste, Bertrand Tavitian, Sven Klussmann, Bernard Rousseau
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 46:1205-1219
Spiegelmers are high-affinity l-enantiomeric oligonucleotide ligands (aptamers) that display high resistance to enzymatic degradation compared to d-oligonucleotides. Spiegelmers belong to the third generation of aptamers, and are currently extensivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c020b669e7c1e7542a69627f36859d89
https://doi.org/10.1002/jlcr.781
https://doi.org/10.1002/jlcr.781
Publikováno v:
Journal of Biological Chemistry. 277:40617-40622
A systematic mutagenesis study of the "10-23" DNA enzyme was performed to analyze the sequence requirements of its catalytic domain. Therefore, each of the 15 core nucleotides was substituted separately by the remaining three naturally occurring nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f0346ceca76912ac3cc9c5bc203ef3
https://doi.org/10.1074/jbc.m207094200
https://doi.org/10.1074/jbc.m207094200
Publikováno v:
Biochemical and Biophysical Research Communications. 290:1583-1588
Alzheimer's disease is correlated with the deposition of amyloid peptides in the brain of the patients. The amyloid is thus a major target in the search for novel diagnostic and therapeutic approaches. The present work employs in vitro selection to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255ca7e6716f692c9f9c4e1a0714194f
https://doi.org/10.1006/bbrc.2002.6354
https://doi.org/10.1006/bbrc.2002.6354