Acute and prolonged ketosis lower serum IGF-I levels in human subjects

Autor: Mads Svart, Alisa D. Kjaergaard, Thien Vinh Luong, Lars C. Gormsen, Niels Møller, Jens Otto L. Jørgensen, Esben Søndergaard

Publikováno v: Endocrine and Metabolic Science, Vol 16, Iss , Pp 100207- (2024)

Objective: Metabolic health and longevity are influenced by numerous factors including the growth hormone (GH) – insulin-like growth factor I (IGFI) axis and ketone bodies (KB). However, data on the impact of KB exposure on GH and IGF-I levels a

Externí odkaz: https://doaj.org/article/9f620f89108d4ace9143e1cf0efb20ac

Guidance for the treatment of adult growth hormone deficiency with somapacitan, a long-acting growth hormone preparation

Autor: Martin Bidlingmaier, Beverly M.K. Biller, David Clemmons, Jens Otto L. Jørgensen, Hiroshi Nishioka, Yutaka Takahashi

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

Adult growth hormone deficiency (AGHD) is a rare endocrine disorder characterized by an abnormal body composition, metabolic abnormalities associated with increased cardiovascular diseases, bone loss, and impaired quality of life. Daily subcutaneous

Externí odkaz: https://doaj.org/article/342be24d33884ae4b11fbb92d31b1fed

Temporal patterns of lipolytic regulators in adipose tissue after acute growth hormone exposure in human subjects: A randomized controlled crossover trial

Autor: Astrid Johannesson Hjelholt, Kevin Y. Lee, Mai Christiansen Arlien-Søborg, Steen Bønløkke Pedersen, John J. Kopchick, Vishwajeet Puri, Niels Jessen, Jens Otto L. Jørgensen

Publikováno v: Molecular Metabolism, Vol 29, Iss , Pp 65-75 (2019)

Objective: Growth hormone (GH) stimulates lipolysis, but the underlying mechanisms remain incompletely understood. We examined the effect of GH on the expression of lipolytic regulators in adipose tissue (AT). Methods: In a randomized, placebo-contro

Externí odkaz: https://doaj.org/article/df977ca1ec0d4245be3b77f6148036fd

Gene expression profiling of subcutaneous adipose tissue reveals new biomarkers in acromegaly

Autor: Camilla M Falch, Mai Christiansen Arlien-Søborg, Jakob Dal, Arvind Y M Sundaram, Annika E Michelsen, Thor Ueland, Linn Guro Olsen, Ansgar Heck, Jens Bollerslev, Jens Otto L Jørgensen, Nicoleta C Olarescu

Publikováno v: Falch, C M, Arlien-Søborg, M C, Dal, J, Sundaram, A Y M, Michelsen, A E, Ueland, T, Olsen, L G, Heck, A, Bollerslev, J, Jørgensen, J O L & Olarescu, N C 2023, ' Gene expression profiling of subcutaneous adipose tissue reveals new biomarkers in acromegaly ', European Journal of Endocrinology, vol. 188, no. 3, pp. 310-321 . https://doi.org/10.1093/ejendo/lvad031
Falch, C M, Arlien-Søborg, M C, Dal, J, Sundaram, A Y M, Michelsen, A E, Ueland, T, Olsen, L G, Heck, A, Bollerslev, J, Jørgensen, J O L & Olarescu, N C 2023, ' Gene expression profiling of subcutaneous adipose tissue reveals new biomarkers in acromegaly ', European Journal of Endocrinology, vol. 188, no. 3, pp. 310–321 . https://doi.org/10.1093/ejendo/lvad031

Context: Active acromegaly is characterized by lipolysis-induced insulin resistance, which suggests adipose tissue (AT) as a primary driver of metabolic aberrations.Objective: To study the gene expression landscape in AT in patients with acromegaly b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93237f05c499c89a6d9e7e6b9678ecfe
https://doi.org/10.1093/ejendo/lvad031

[Genetic screening for mutations enables early diagnosis of pituitary adenomas]

Autor: Jakob, Dal, Mette, Gaustadnes, Kurt, Kristensen, Claus H, Gravholt, Jens Otto L, Jørgensen

Publikováno v: Ugeskrift for laeger. 176(1)

Mutations in the aryl hydrocarbon receptor interaction protein gene (AIP) occur in familial pituitary adenomas as an autosomal dominant inheritance with a 15-30% penetrance. The AIP mutation-associated pituitary adenomas are generally large, the onse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::16ef32e6493a1c355c64e7ea5db67ed6
https://pubmed.ncbi.nlm.nih.gov/24629609