Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jens O Watzlawik"'
Autor:
Meghan M Painter, James H Morrison, Laurie J Zoecklein, Tommy A Rinkoski, Jens O Watzlawik, Louisa M Papke, Arthur E Warrington, Allan J Bieber, William E Matchett, Kari L Turkowski, Eric M Poeschla, Moses Rodriguez
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005311 (2015)
For many emerging and re-emerging infectious diseases, definitive solutions via sterilizing adaptive immunity may require years or decades to develop, if they are even possible. The innate immune system offers alternative mechanisms that do not requi
Externí odkaz:
https://doaj.org/article/a7744516c8e147598d583085c9739909
Autor:
Jens O Watzlawik, Robert J Kahoud, Ryan J O'Toole, Katherine A M White, Alyssa R Ogden, Meghan M Painter, Bharath Wootla, Louisa M Papke, Aleksandar Denic, Jill M Weimer, William A Carey, Moses Rodriguez
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128007 (2015)
Neonatal white matter injury (nWMI) is an increasingly common cause of cerebral palsy that results predominantly from hypoxic injury to progenitor cells including those of the oligodendrocyte lineage. Existing mouse models of nWMI utilize prolonged p
Externí odkaz:
https://doaj.org/article/4e8be402acda461b8f1c8ff02e22c4f0
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55149 (2013)
Promotion of remyelination is a major goal in treating demyelinating diseases such as multiple sclerosis (MS). The recombinant human monoclonal IgM, rHIgM22, targets myelin and oligodendrocytes (OLs) and promotes remyelination in animal models of MS.
Externí odkaz:
https://doaj.org/article/19d7bfe92e694e078323a2b43e79be07
Autor:
Fidha Nazreen Kunnath Muhammedkutty, Ramesh Prasad, Yuan Gao, Tarunya Rao Sudarshan, Alicia S. Robang, Jens O. Watzlawik, Terrone L. Rosenberry, Anant K. Paravastu, Huan-Xiang Zhou
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Amyloid beta (Aβ) aggregation is a slow process without seeding or assisted nucleation. Sodium dodecyl sulfate (SDS) micelles stabilize Aβ42 small oligomers (in the dimer to tetramer range); subsequent SDS removal leads to a 150-kD Aβ42 o
Externí odkaz:
https://doaj.org/article/cdbaac7f83d642a1869fa7beaa06d63f
Autor:
Yuan Gao, Ramesh Prasad, Peter S. Randolph, Jens O. Watzlawik, Alicia S. Robang, Cong Guo, Scott M. Stagg, Huan-Xiang Zhou, Terrone L. Rosenberry, Anant K. Paravastu
Previous reports revealed that sodium dodecyl sulfate near its critical micelle concentration can drive the assembly of Aβ42 along an oligomeric pathway. This pathway produces a 150 kDa peptide oligomer (approximately 32 peptide molecules or protome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bf4eb89d7245c51e1f36de04d779e83
https://doi.org/10.1101/2022.12.06.519347
https://doi.org/10.1101/2022.12.06.519347
Autor:
Heather L. Melrose, Fabienne C. Fiesel, Xu Hou, Wolfdieter Springer, Silvia S. Kang, Chia Chen Liu, Michael G. Heckman, Jens O. Watzlawik, Casey Cook, Michael DeTure, Leonard Petrucelli, Fadi S. Hanna Al-Shaikh, Owen A. Ross, Ronald L. Walton, Melissa E. Murray, Guojun Bu, John D. Fryer, Nilufer Ertekin-Taner, Dennis W. Dickson, Wen Lang Lin, Nancy N. Diehl
Publikováno v:
Alzheimer's & Dementia
Introduction The cytoprotective PTEN‐induced kinase 1 (PINK1)‐parkin RBR E3 ubiquitin protein ligase (PRKN) pathway selectively labels damaged mitochondria with phosphorylated ubiquitin (pS65‐Ub) for their autophagic removal (mitophagy). Becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e2c426e0b304d6ec736d0bf3b4f2bc
https://doi.org/10.1002/alz.12198
https://doi.org/10.1002/alz.12198
Autor:
Xu Hou, Fabienne C. Fiesel, Jens O. Watzlawik, Michael G. Heckman, Wolfdieter Springer, Owen A. Ross, Matthew S. Goldberg, Zbigniew K. Wszolek, Michael DeTure, Sandeep Kumar Barodia, Dennis W. Dickson, Joanna Siuda, Chloe Ramnarine, Tania F. Gendron, Guojun Bu, Dominika Fricova, Clemens R. Scherzer
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Mitochondrial dysfunction is an early, imminent event in neurodegenerative disorders including Parkinson disease (PD) and Alzheimer disease (AD). The enzymatic pair PINK1 and PRKN/Parkin recognize and transiently label damaged mitochondria with ubiqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c2419063e2d5c255d720e534acad7d
http://europepmc.org/articles/PMC8496550
http://europepmc.org/articles/PMC8496550
Publikováno v:
J Mol Biol
Impaired protein homeostasis and accumulation of damaged or abnormally modified protein are common disease mechanisms in many neurodegenerative disorders, including Parkinson's disease (PD). As one of the major degradation pathways, autophagy plays a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd6ba4c69850071dcf2a937a81f4556
https://doi.org/10.1016/j.jmb.2020.01.037
https://doi.org/10.1016/j.jmb.2020.01.037
Autor:
Fidha Nazreen Kunnath Muhammedkutty, Ramesh Prasad, Yuan Gao, Alicia S. Robang, Jens O. Watzlawik, Terrone Rosenberry, Anant K. Paravastu, Huan-Xiang Zhou
Publikováno v:
Biophysical Journal. 122:313a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e0f29f2b66106481bdc938c3c9f7474
https://doi.org/10.1016/j.bpj.2022.11.1759
https://doi.org/10.1016/j.bpj.2022.11.1759
Autor:
Ying Wang, Santanu Bhattacharya, Ramcharan Singh Angom, Pritam Das, Jens O. Watzlawik, Enfeng Wang, Terrone L. Rosenberry, Krishnendu Pal, Debabrata Mukhopadhyay
Publikováno v:
The FASEB Journal. 33:4626-4637
Aggregated amyloid β (Aβ) peptides in the Alzheimer’s disease (AD) brain are hypothesized to trigger several downstream pathologies, including cerebrovascular dysfunction. Previous studies have shown that Aβ peptides can have antiangiogenic prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa9a08a854ce85e56083f6316f01038
https://doi.org/10.1096/fj.201802003r
https://doi.org/10.1096/fj.201802003r