Zobrazeno 1 - 10
of 631
pro vyhledávání: '"Jens Meiler"'
Autor:
Laura M Chamness, Charles P Kuntz, Andrew G McKee, Wesley D Penn, Christopher M Hemmerich, Douglas B Rusch, Hope Woods, Dyotima, Jens Meiler, Jonathan P Schlebach
Publikováno v:
eLife, Vol 12 (2024)
Many membrane proteins are prone to misfolding, which compromises their functional expression at the plasma membrane. This is particularly true for the mammalian gonadotropin-releasing hormone receptor GPCRs (GnRHR). We recently demonstrated that evo
Externí odkaz:
https://doaj.org/article/87e6dc4267994ade8aebd09e14ada9b5
Autor:
Moritz Ertelt, Vikram Khipple Mulligan, Jack B Maguire, Sergey Lyskov, Rocco Moretti, Torben Schiffner, Jens Meiler, Clara T Schoeder
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 3, p e1011939 (2024)
Post-translational modifications (PTMs) of proteins play a vital role in their function and stability. These modifications influence protein folding, signaling, protein-protein interactions, enzyme activity, binding affinity, aggregation, degradation
Externí odkaz:
https://doaj.org/article/77e6f2dca787462c97d0b815eb05045b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Delivery to the correct membrane domain in polarized epithelial cells is a critical regulatory mechanism for transmembrane proteins. The trafficking of these proteins is directed by short amino acid sequences known as sorting motifs. In six basolater
Externí odkaz:
https://doaj.org/article/fadd5f5b3a004857bb715f6b4bc03be0
Autor:
Thillai V. Sekar, Eslam A. Elghonaimy, Katy L. Swancutt, Sebastian Diegeler, Isaac Gonzalez, Cassandra Hamilton, Peter Q. Leung, Jens Meiler, Cristina E. Martina, Michael Whitney, Todd A. Aguilera
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract In the rapidly advancing field of synthetic biology, there exists a critical need for technology to discover targeting moieties for therapeutic biologics. Here we present INSPIRE-seq, an approach that utilizes a nanobody library and next-gen
Externí odkaz:
https://doaj.org/article/ebb3ebd8f07a4871845f2e1f02176d2c
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0297560 (2024)
Variants in the cystic fibrosis transmembrane conductance regulator gene (CFTR) result in cystic fibrosis-a lethal autosomal recessive disorder. Missense variants that alter a single amino acid in the CFTR protein are among the most common cystic fib
Externí odkaz:
https://doaj.org/article/d9b8d3609c484310a0dc18ddebc2180b
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2024)
Ion channels play a crucial role in a variety of physiological and pathological processes, making them attractive targets for drug development in diseases such as diabetes, epilepsy, hypertension, cancer, and chronic pain. Despite the importance of i
Externí odkaz:
https://doaj.org/article/e9362dfdb300400e9882cb7185ffbb0a
Autor:
Nina G. Bozhanova, Andrew I. Flyak, Benjamin P. Brown, Stormy E. Ruiz, Jordan Salas, Semi Rho, Robin G. Bombardi, Luke Myers, Cinque Soto, Justin R. Bailey, James E. Crowe, Pamela J. Bjorkman, Jens Meiler
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Identifying determinants of broadly neutralizing antibodies against hepatitis C virus (HCV) may guide HCV vaccine design. Here, the authors discover new anti-HCV antibodies using computational screening and analyze the amino acid composition and sequ
Externí odkaz:
https://doaj.org/article/f9573f4cd2774fcb9a4cbb1c42411547
Autor:
Taylor B Engdahl, Elad Binshtein, Rebecca L Brocato, Natalia A Kuzmina, Lucia M Principe, Steven A Kwilas, Robert K Kim, Nathaniel S Chapman, Monique S Porter, Pablo Guardado-Calvo, Félix A Rey, Laura S Handal, Summer M Diaz, Irene A Zagol-Ikapitte, Minh H Tran, W Hayes McDonald, Jens Meiler, Joseph X Reidy, Andrew Trivette, Alexander Bukreyev, Jay W Hooper, James E Crowe
Publikováno v:
eLife, Vol 12 (2023)
Hantaviruses are high-priority emerging pathogens carried by rodents and transmitted to humans by aerosolized excreta or, in rare cases, person-to-person contact. While infections in humans are relatively rare, mortality rates range from 1 to 40% dep
Externí odkaz:
https://doaj.org/article/8473aa7cf9fd4f6f8543805191bc6878
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 3, p e1010947 (2023)
Lipid molecules such as cholesterol interact with the surface of integral membrane proteins (IMP) in a mode different from drug-like molecules in a protein binding pocket. These differences are due to the lipid molecule's shape, the membrane's hydrop
Externí odkaz:
https://doaj.org/article/add00a1800eb4d25b037fad3a0e8a498
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Glycan masking is a novel technique in reverse vaccinology in which sugar chains (glycans) are added on the surface of immunogen candidates to hide regions of low interest and thus focus the immune system on highly therapeutic epitopes. This shieldin
Externí odkaz:
https://doaj.org/article/409248f2407c44d8ae7108040b7b47e7