Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Jens Mayer"'
Publikováno v:
Environmental Sciences Europe, Vol 36, Iss 1, Pp 1-17 (2024)
Abstract Background Water bodies are affected by chemical contamination, including micropollutants, which is not fully captured by conventional chemical monitoring methods. The inclusion of integrative, effect-based in vivo and in vitro methods in st
Externí odkaz:
https://doaj.org/article/eee16a0661f4485d890a210d52235ec3
Autor:
Martin Hart, Fabian Kern, Claudia Fecher-Trost, Lena Krammes, Ernesto Aparicio, Annika Engel, Pascal Hirsch, Viktoria Wagner, Verena Keller, Georges Pierre Schmartz, Stefanie Rheinheimer, Caroline Diener, Ulrike Fischer, Jens Mayer, Markus R. Meyer, Veit Flockerzi, Andreas Keller, Eckart Meese
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 4, Pp 935-945 (2024)
Abstract The identification of targetomes remains a challenge given the pleiotropic effect of miRNAs, the limited effects of miRNAs on individual targets, and the sheer number of estimated miRNA–target gene interactions (MTIs), which is around 44,5
Externí odkaz:
https://doaj.org/article/3efe0c622e26455595bea061ca0cb9f0
Autor:
Caroline Diener, Martin Hart, Claudia Fecher-Trost, Jessica Knittel, Stefanie Rheinheimer, Markus R. Meyer, Jens Mayer, Veit Flockerzi, Andreas Keller, Eckart Meese
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-16 (2023)
Abstract Among the concepts in biology that are widely taken granted is a potentiated cooperative effect of multiple miRNAs on the same target. This strong hypothesis contrasts insufficient experimental evidence. The quantity as well as the quality o
Externí odkaz:
https://doaj.org/article/6107573b558b458e821e4f0ddff8a018
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101281- (2022)
Summary: Human endogenous retroviruses (HERVs) comprise many regulatory elements and can regulate host gene activity at different expression levels via multiple mechanisms. Here, we introduce a step-by-step protocol to activate or repress transcripti
Externí odkaz:
https://doaj.org/article/920440cbf92248c2842e2401a3ffeb4d
Autor:
Nicole Grandi, Maria Paola Pisano, Martina Demurtas, Jonas Blomberg, Gkikas Magiorkinis, Jens Mayer, Enzo Tramontano
Publikováno v:
Mobile DNA, Vol 11, Iss 1, Pp 1-16 (2020)
Abstract Background Endogenous Retroviruses (ERVs) constitute approximately 8% of every human genome and are relics of ancestral infections that affected the germ line cells. The ERV-W group contributed to primate physiology by providing an envelope
Externí odkaz:
https://doaj.org/article/7dc98f2a188247a9951f169bf33de0d1
Autor:
Giuseppe Rigogliuso, Martin L. Biniossek, John L. Goodier, Bettina Mayer, Gavin C. Pereira, Oliver Schilling, Eckart Meese, Jens Mayer
Publikováno v:
Mobile DNA, Vol 10, Iss 1, Pp 1-22 (2019)
Abstract Background A considerable portion of the human genome derives from retroviruses inherited over millions of years. Human endogenous retroviruses (HERVs) are usually severely mutated, yet some coding-competent HERVs exist. The HERV-K(HML-2) gr
Externí odkaz:
https://doaj.org/article/81513dc2430747268cbb6801fad48c08
Autor:
Gavin C. Pereira, Laura Sanchez, Paul M. Schaughency, Alejandro Rubio-Roldán, Jungbin A. Choi, Evarist Planet, Ranjan Batra, Priscilla Turelli, Didier Trono, Lyle W. Ostrow, John Ravits, Haig H. Kazazian, Sarah J. Wheelan, Sara R. Heras, Jens Mayer, Jose Luis García-Pérez, John L. Goodier
Publikováno v:
Mobile DNA, Vol 9, Iss 1, Pp 1-30 (2018)
ABSTRACT Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving loss of motor neurons and having no known cure and uncertain etiology. Several studies have drawn connections between altered retrotransposon expre
Externí odkaz:
https://doaj.org/article/4c05b9012a7d41358fb9b99446dd09e9
Autor:
Robert J. Gifford, Jonas Blomberg, John M. Coffin, Hung Fan, Thierry Heidmann, Jens Mayer, Jonathan Stoye, Michael Tristem, Welkin E. Johnson
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-11 (2018)
Abstract Retroviral integration into germline DNA can result in the formation of a vertically inherited proviral sequence called an endogenous retrovirus (ERV). Over the course of their evolution, vertebrate genomes have accumulated many thousands of
Externí odkaz:
https://doaj.org/article/189773ca9a014c75835a6506dadafdde
Autor:
Jens Mayer, Christian Harz, Laura Sanchez, Gavin C. Pereira, Esther Maldener, Sara R. Heras, Lyle W. Ostrow, John Ravits, Ranjan Batra, Eckart Meese, Jose Luis García-Pérez, John L. Goodier
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-25 (2018)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. About 90% of ALS cases are without a known genetic cause. The human endogenous retrovirus multi-copy HERV-K(HML-2) group was recently reported to potential
Externí odkaz:
https://doaj.org/article/a614b9b1c6a245569d81d26e1a7fc6ea
Publikováno v:
BMC Evolutionary Biology, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background The genomes of all vertebrates harbor remnants of ancient retroviral infections, having affected the germ line cells during the last 100 million years. These sequences, named Endogenous Retroviruses (ERVs), have been transmitted t
Externí odkaz:
https://doaj.org/article/4bdee8cc4f894e5980f479e66eb236df