Positive chronotropic action of HCN channel antagonism in human collecting lymphatic vessels

Autor: Jens Majgaard, Frederik G. Skov, Sukhan Kim, Vibeke Elisabeth Hjortdal, Donna M. B. Boedtkjer

Publikováno v: Physiological Reports, Vol 10, Iss 16, Pp n/a-n/a (2022)

Abstract Spontaneous action potentials precede phasic contractile activity in human collecting lymphatic vessels. In this study, we investigated the expression of hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels in human collect

Externí odkaz: https://doaj.org/article/a8c4ba86d190492ea1e777969522f948

Spontaneous and α-adrenoceptor-induced contractility in human collecting lymphatic vessels require chloride

Autor: Niklas Telinius, Sheyanth Mohanakumar, Donna Briggs Boedtkjer, Vibeke E. Hjortdal, Einar Pahle, Jens Majgaard, Niels Katballe

Publikováno v: Mohanakumar, S, Majgaard, J, Telinius, N, Katballe, N, Pahle, E, Hjortdal, V E & Boedtkjer, D M B 2018, ' Spontaneous and α-adrenoceptor-induced contractility in human collecting lymphatic vessels require chloride ', A J P: Heart and Circulatory Physiology (Online), vol. 315, no. 2, pp. H389-H401 . https://doi.org/10.1152/ajpheart.00551.2017

Human lymphatic vessels are myogenically active and respond to sympathetic stimulation. The role of various cations in this behavior has recently been investigated, but whether the anion Cl− is essential is unclear. With ethical approval and inform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bee70e2d708baf1f42647420db7284b
https://doi.org/10.1152/ajpheart.00551.2017

Spontaneous and Evoked Contractility of Human Intestinal Lymphatic Vessels

Autor: Niklas Telinius, Sheyanth Mohanakumar, Vibeke E. Hjortdal, Einar Pahle, Donna Briggs Boedtkjer, Jørn Nielsen, Jens Majgaard, Christian Aalkjaer

Publikováno v: Telinius, N, Majgaard, J C, Mohanakumar, S, Pahle, E, Nielsen, J, Hjortdal, V, Aalkjær, C & Boedtkjer, D B 2017, ' Spontaneous and Evoked Contractility of Human Intestinal Lymphatic Vessels ', Lymphatic research and biology, vol. 15, no. 1, pp. 17-22 . https://doi.org/10.1089/lrb.2016.0039

BACKGROUND: Mesenteric lymphatic vessels (MLVs) from various animal species have been intensively studied. We aimed to establish the viability and basic contractile characteristics of human MLVs maintained in vitro and to determine the reactivity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2946beccfc38176a04f7d168205a6ea4
https://pubmed.ncbi.nlm.nih.gov/28323569

Human lymphatic vessel contractile activity is inhibited in vitro but not in vivo by the calcium channel blocker nifedipine

Autor: Niklas, Telinius, Sheyanth, Mohanakumar, Jens, Majgaard, Sukhan, Kim, Hans, Pilegaard, Einar, Pahle, Jørn, Nielsen, Marc, de Leval, Christian, Aalkjaer, Vibeke, Hjortdal, Donna Briggs, Boedtkjer

Publikováno v: The Journal of physiology. 592(21)

Calcium channel blockers (CCB) are widely prescribed anti-hypertensive agents. The commonest side-effect, peripheral oedema, is attributed to a larger arterial than venous dilatation causing increased fluid filtration. Whether CCB treatment is detrim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2220eb6a97345f46f4cb8493b97eea3e
https://pubmed.ncbi.nlm.nih.gov/25172950