Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Jens M. Hohlfeld"'
Autor:
Kenji Cunnion, Jessica Goss, Pamela Hair, Linda Dell, Destrey Roberson, Ulrich Thienel, Meike Müller, Saskia Carstensen-Aurèche, Philipp Badorrek, Olaf Holz, Jens M. Hohlfeld
Publikováno v:
ERJ Open Research, Vol 10, Iss 4 (2024)
Background This study was a randomised, double-blind, placebo-controlled study intended to establish the translatability of the RLS-0071 mechanisms of action from animal disease models to humans by inhibiting neutrophil-mediated inflammation at the t
Externí odkaz:
https://doaj.org/article/291ea86fe0e24f398dea37888ec168ba
Autor:
Philipp Badorrek, Claudia Diefenbach, Harald Kögler, Anastasia Eleftheraki, Friedeborg Seitz, Jens M. Hohlfeld
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 8, Pp n/a-n/a (2024)
Abstract Novel treatments are needed to reduce inflammation, improve symptoms, address exacerbations, and slow disease progression in bronchiectasis. Cathepsin C (CatC) inhibition promises to achieve this through reduction of neutrophil‐derived ser
Externí odkaz:
https://doaj.org/article/6cf4e4560b7a4ccd929fffaee02c03ff
Publikováno v:
Pulmonary Therapy, Vol 10, Iss 1, Pp 109-122 (2024)
Abstract Introduction The selection of inhaler device is of critical importance in chronic obstructive pulmonary disease (COPD) as the interaction between a patient’s inhalation profile and the aerosol characteristics of an inhaler can affect drug
Externí odkaz:
https://doaj.org/article/832681727c5c44aeb48ec95bd5e0d15e
Autor:
Christina Gress, Tobias Litzenburger, Ramona Schmid, Ke Xiao, Florian Heissig, Meike Muller, Abhya Gupta, Jens M. Hohlfeld
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Segmental instillation of lipopolysaccharide (LPS) by bronchoscopy safely induces transient airway inflammation in human lungs. This model enables investigation of pulmonary inflammatory mechanisms as well as pharmacodynamic analysis of inve
Externí odkaz:
https://doaj.org/article/561b2cec38ae43e5a0eb80d8141807e5
Publikováno v:
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Background Surfactant phospholipid (PL) composition plays an important role in lung diseases. We compared the PL composition of non-invasively collected exhaled breath particles (PEx) with bronchoalveolar lavage (BAL) and induced sputum (ISP
Externí odkaz:
https://doaj.org/article/c6ba4ea50d7d4ddcbd54073ea31ecd63
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Particles in exhaled air (PEx) are generated when collapsed small airways reopen during breathing. PEx can be noninvasively collected by particle impaction, allowing the analysis of undiluted epithelial lining fluid (ELF). We used the endoto
Externí odkaz:
https://doaj.org/article/b2bc9773bb434ad0964f4fca1ebda65e
Autor:
Saskia Carstensen, Christina Gress, Veit J. Erpenbeck, Shamsah D. Kazani, Jens M. Hohlfeld, David A. Sandham, Meike Müller
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background Prostaglandin D2 (PGD2) signaling via prostaglandin D2 receptor 2 (DP2) contributes to atopic and non-atopic asthma. Inhibiting DP2 has shown therapeutic benefit in certain subsets of asthma patients, improving eosinophilic airway
Externí odkaz:
https://doaj.org/article/9ef12645bb7e4800853ed9a7b72fc9b0
Autor:
Saskia Carstensen, Meike Müller, Glaiza L. A. Tan, Khristine Amber Pasion, Jens M. Hohlfeld, Victoria L. M. Herrera, Nelson Ruiz-Opazo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Background and objectiveThe correlation (Rs > 0.7) of neutrophils expressing the dual endothelin1/signal peptide receptor (DEspR+CD11b+/CD66b+) with severity of hypoxemia (SF-ratio) and multi-organ failure (SOFA-score) in patients with acute respirat
Externí odkaz:
https://doaj.org/article/a402768b25f34218b6105a4db2b4c356
Autor:
Anna Esteve-Codina, Thomas P. Hofer, Dorothe Burggraf, Marion S. Heiss-Neumann, Wolfgang Gesierich, Anne Boland, Robert Olaso, Marie-Therese Bihoreau, Jean-Francois Deleuze, Winfried Moeller, Otmar Schmid, María Soler Artigas, Kathrin Renner, Jens M. Hohlfeld, Tobias Welte, Thomas Fuehner, Lukas Jerrentrup, Andreas Rembert Koczulla, Timm Greulich, Antje Prasse, Joachim Müller-Quernheim, Sumit Gupta, Christopher Brightling, Deepak R. Subramanian, David G. Parr, Umme Kolsum, Vandana Gupta, Imre Barta, Balázs Döme, János Strausz, Mariarita Stendardo, Marco Piattella, Piera Boschetto, Damian Korzybski, Dorota Gorecka, Adam Nowinski, Marc Dabad, Marcos Fernández-Callejo, David Endesfelder, Wolfgang zu Castell, Pieter S. Hiemstra, Per Venge, Elfriede Noessner, Thasso Griebel, Simon Heath, Dave Singh, Ivo Gut, Loems Ziegler-Heitbrock
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory disease and the genes expressed within the lung are crucial to its pathophysiology. We have determined the RNAseq transcriptome of bronchial brush cells from 312 stri
Externí odkaz:
https://doaj.org/article/910271cd28a0431e890028bbd9684f22
Autor:
Henrik Watz, Jens M. Hohlfeld, Dave Singh, Jutta Beier, Zuzana Diamant, Jinming Liu, Shucheng Hua, Khalid Abd-Elaziz, Pascale Pinot, Ieuan Jones, Hanns-Christian Tillmann
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-5 (2020)
Abstract Indacaterol (IND; 150 μg), glycopyrronium (GLY; 50 μg) and mometasone furoate (MF; 160 μg [high-dose ICS] and 80 μg [medium-dose ICS]) have been formulated as a once-daily (o.d.) fixed-dose combination treatment delivered via the Breezha
Externí odkaz:
https://doaj.org/article/d541d016783b409fa448e2abf8959460