Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jens Lamerz"'
Autor:
Manaswini Sivaramakrishnan, Kathleen D. McCarthy, Sébastien Campagne, Sylwia Huber, Sonja Meier, Angélique Augustin, Tobias Heckel, Hélène Meistermann, Melanie N. Hug, Pascale Birrer, Ahmed Moursy, Sarah Khawaja, Roland Schmucki, Nikos Berntenis, Nicolas Giroud, Sabrina Golling, Manuel Tzouros, Balazs Banfai, Gonzalo Duran-Pacheco, Jens Lamerz, Ying Hsiu Liu, Thomas Luebbers, Hasane Ratni, Martin Ebeling, Antoine Cléry, Sergey Paushkin, Adrian R. Krainer, Frédéric H.-T. Allain, Friedrich Metzger
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Small molecules correcting the splicing deficit of the survival of motor neuron 2 (SMN2) gene have been identified as having therapeutic potential. Here, the authors provide evidence that SMN2 mRNA forms a ribonucleoprotein complex that can be specif
Externí odkaz:
https://doaj.org/article/86ed63c63e664f938352b802e813bfcc
Autor:
Vilém Guryča, Daniel Roeder, Paolo Piraino, Jens Lamerz, Axel Ducret, Hanno Langen, Paul Cutler
Publikováno v:
Biology, Vol 3, Iss 1, Pp 205-219 (2014)
The identification of novel biomarkers from human plasma remains a critical need in order to develop and monitor drug therapies for nearly all disease areas. The discovery of novel plasma biomarkers is, however, significantly hampered by the complexi
Externí odkaz:
https://doaj.org/article/23708e05ada14c3eb266506a39ba55e0
Autor:
Barbara Klughammer, Laurent Essioux, Hanno Langen, David W. Avila, Manuel Tzouros, Guillemette Duchateau-Nguyen, Johannes C. Hermann, Stefan Scheiblich, Sabrina Golling, Hélène Meistermann, Jens Lamerz, Angélique Augustin
PDF file - 60K, Schematic diagram of the experimental framework applied to perform label-free, quantitative chemical proteomics on erlotinib and gefitinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9198f2fb78276d5dbe86098b85950f9
https://doi.org/10.1158/1535-7163.22497625.v1
https://doi.org/10.1158/1535-7163.22497625.v1
Autor:
Barbara Klughammer, Laurent Essioux, Hanno Langen, David W. Avila, Manuel Tzouros, Guillemette Duchateau-Nguyen, Johannes C. Hermann, Stefan Scheiblich, Sabrina Golling, Hélène Meistermann, Jens Lamerz, Angélique Augustin
Although both erlotinib and gefitinib target the EGF receptor (EGFR), erlotinib is effective in patients with EGFR wild-type or mutated tumors, whereas gefitinib is only beneficial for patients with activating mutations. To determine whether these di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8db1bb1a1af69d9296d2031954eb23
https://doi.org/10.1158/1535-7163.c.6535669
https://doi.org/10.1158/1535-7163.c.6535669
Autor:
Barbara Klughammer, Laurent Essioux, Hanno Langen, David W. Avila, Manuel Tzouros, Guillemette Duchateau-Nguyen, Johannes C. Hermann, Stefan Scheiblich, Sabrina Golling, Hélène Meistermann, Jens Lamerz, Angélique Augustin
XLSX file - 24K, Statistics of proteins that significantly decrease in their relative abundance with increasing compound concentration, in at least one of the two compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d0dea924e8755f7493071f469dbc5b
https://doi.org/10.1158/1535-7163.22497622.v1
https://doi.org/10.1158/1535-7163.22497622.v1
Autor:
Barbara Klughammer, Laurent Essioux, Hanno Langen, David W. Avila, Manuel Tzouros, Guillemette Duchateau-Nguyen, Johannes C. Hermann, Stefan Scheiblich, Sabrina Golling, Hélène Meistermann, Jens Lamerz, Angélique Augustin
PDF file - 96K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f81026ad59ead1a9b037683c138a3fe
https://doi.org/10.1158/1535-7163.22497619.v1
https://doi.org/10.1158/1535-7163.22497619.v1
Autor:
Jens Lamerz, Oana Mihaela Danila, Andreas Schuster, Janine Burren, Christian Moessner, Wolfgang Göhring, Pankaj Rege, Helmut Stahr, Stefan Hildbrand, Daniel Coleman
Publikováno v:
PDA journal of pharmaceutical science and technology. 76(6)
The identification of critical process parameters in biologics and small molecule process development is a key element of quality by design. The objectivity and consistency of procedures to identify critical process parameters can be improved with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b1382aaa45c16bd0e2a4301be168db
https://pubmed.ncbi.nlm.nih.gov/35840347
https://pubmed.ncbi.nlm.nih.gov/35840347
Autor:
Anna Pratsinis, Yuchen Fan, Michaela Portmann, Michal Hammel, Ponien Kou, Apoorva Sarode, Philippe Ringler, Lubomir Kovacik, Matthias E. Lauer, Jens Lamerz, Greg L. Hura, Chun-Wan Yen, Michael Keller
Publikováno v:
International Journal of Pharmaceutics. 637:122874
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9119686a1b768d12241a435ca24916b3
https://doi.org/10.1016/j.ijpharm.2023.122874
https://doi.org/10.1016/j.ijpharm.2023.122874
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 72:188-198
We propose a new index and graphical display for quantifying and visualizing process performance in the pharmaceutical industry. These tools can provide management a comprehensive, high level overview of the process performance of a global manufactur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cb6331dee3d5e15ad2690aa88e4c89
https://doi.org/10.5731/pdajpst.2017.008177
https://doi.org/10.5731/pdajpst.2017.008177
Autor:
Lothar Lindemann, Michal Stawarski, Ruth C. Werthmann, Jens Lamerz, Catherine Diener, Christophe Fischer, Thorsten Fritzius, Martin Gassmann, Angélique Augustin, Luca Trovò, Bernhard Bettler, Adi Raveh, Manuel Tzouros
Publikováno v:
Neuropharmacology. 190:108426
For a long time metabotropic glutamate receptors (mGluRs) were thought to regulate neuronal functions as obligatory homodimers. Recent reports, however, indicate the existence of heterodimers between group-II and -III mGluRs in the brain, which diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73f87087a186e1c3ef8d0d145dac862
https://doi.org/10.1016/j.neuropharm.2020.108426
https://doi.org/10.1016/j.neuropharm.2020.108426