Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jens L Hukelmann"'
Autor:
Linda V Sinclair, Andrew JM Howden, Alejandro Brenes, Laura Spinelli, Jens L Hukelmann, Andrew N Macintyre, Xiaojing Liu, Sarah Thomson, Peter M Taylor, Jeffrey C Rathmell, Jason W Locasale, Angus I Lamond, Doreen A Cantrell
Publikováno v:
eLife, Vol 8 (2019)
Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell differentiation. The present study uses high resolution mass spect
Externí odkaz:
https://doaj.org/article/7d4cdb633ab44514a668ee05c272cae5
Autor:
Dylan G. Ryan, Elena V. Knatko, Alva M. Casey, Jens L. Hukelmann, Sharadha Dayalan Naidu, Alejandro J. Brenes, Thanapon Ekkunagul, Christa Baker, Maureen Higgins, Laura Tronci, Efterpi Nikitopolou, Tadashi Honda, Richard C. Hartley, Luke A.J. O’Neill, Christian Frezza, Angus I. Lamond, Andrey Y. Abramov, J. Simon C. Arthur, Doreen A. Cantrell, Michael P. Murphy, Albena T. Dinkova-Kostova
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103827- (2022)
Summary: To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH associated protein
Externí odkaz:
https://doaj.org/article/59b0d8bd2ed646e68bc099da31cf94d0
Autor:
Róisín M. Loftus, Nadine Assmann, Nidhi Kedia-Mehta, Katie L. O’Brien, Arianne Garcia, Conor Gillespie, Jens L. Hukelmann, Peter J. Oefner, Angus I. Lamond, Clair M. Gardiner, Katja Dettmer, Doreen A. Cantrell, Linda V. Sinclair, David K. Finlay
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Glutamine can feed into the TCA cycle as a fuel for oxidative phosphorylation and thereby can affect metabolic pathways in lymphocytes. Yet here the authors show that glutamine serves predominantly as a signalling molecule that sustains cMyc expressi
Externí odkaz:
https://doaj.org/article/428103db6a8c40348a0ae092d9d2a982
Autor:
Alejandro J. Brenes, Jens L. Hukelmann, Laura Spinelli, Andrew J.M. Howden, Julia M. Marchingo, Linda V. Sinclair, Christina Rollings, Olivia J. James, Iain R Phair, Stephen P. Matthews, Sarah H. Ross, J. Simon C. Arthur, Mahima Swamy, David K. Finlay, Angus I. Lamond, Doreen A. Cantrell
The Immunological Proteome Resource (ImmPRes;http://immpres.co.uk/) is an open access public resource integrating proteomic data generated by large-scale mass-spectrometry analysis of murine hematopoietic populations. The initial focus is T lymphocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6b7aa12c37805d1c91648d60dea911
https://doi.org/10.1101/2022.08.29.505666
https://doi.org/10.1101/2022.08.29.505666
Autor:
Julia M. Marchingo, Doreen A. Cantrell, Andrew J. M. Howden, Laura Spinelli, Marcos Damasio, Jens L. Hukelmann
Publikováno v:
Biochemical Journal. 478:79-98
The integration of multiple signalling pathways that co-ordinate T cell metabolism and transcriptional reprogramming is required to drive T cell differentiation and proliferation. One key T cell signalling module is mediated by extracellular signal-r
Autor:
Harriet Watt, Mahima Swamy, Dina Dikovskaya, Olivia J. James, Alejandro Brenes, Laura Spinelli, Angus I. Lamond, Jens L. Hukelmann, Maud Vandereyken
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural T-IEL,
Autor:
Laura Spinelli, Harriet Watt, Mahima Swamy, Jens L. Hukelmann, Dina Dikovskaya, Angus I. Lamond, Maud Vandereyken, Olivia J. James, Alejandro Brenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f021f5a2346f72e4b1a8232394afef72
https://doi.org/10.7554/elife.70055.sa2
https://doi.org/10.7554/elife.70055.sa2
Autor:
Andrew J. M. Howden, Sarah R. Walmsley, Alex von Kriegsheim, Jens L. Hukelmann, Eilise M. Ryan, Rebecca S. Dickinson, Fiona Murphy, Gio Rodriguez Blanco, Bart Ghesquière, Patrícia Coelho, Doreen A. Cantrell, Emily R. Watts, Pranvera Sadiku, Robert Grecian, Ananda S. Mirchandani, Wesley Vermaelen, Tyler Morrison, Duncan Humphries, Tracie Plant, Moira K. B. Whyte, Andrew J. Finch
Publikováno v:
Watts, E R, Howden, A J M, Morrison, T, Sadiku, P, Hukelmann, J L, Von Kriegsheim, A, Ghesquière, B, Murphy, F, Mirchandani, A S, Humphries, D C, Grecian, R, Ryan, E M, Coelho, P, Rodriguez-blanco, G, Plant, T M, Dickinson, R S, Finch, A J, Vermaelen, W, Cantrell, D A, Whyte, M K B & Walmsley, S R 2021, ' Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism ', Journal of Clinical Investigation . https://doi.org/10.1172/JCI134073
Limiting dysfunctional neutrophilic inflammation while preserving effective immunity requires a better understanding of the processes that dictate neutrophil function in the tissues. Quantitative mass-spectrometry identified how inflammatory murine n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a5393e0379a24b90ce692f5f16f351
https://hdl.handle.net/20.500.11820/6ee67df8-79e3-477f-a412-02d6f22765b7
https://hdl.handle.net/20.500.11820/6ee67df8-79e3-477f-a412-02d6f22765b7
Autor:
Olivia J. James, Laura Spinelli, Alejandro Brenes, Mahima Swamy, Maud Vandereyken, Jens L. Hukelmann, Angus I. Lamond
Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural IEL, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e2f4ca8183a82bc493aac4bf0d8e772
https://doi.org/10.1101/2021.03.15.435419
https://doi.org/10.1101/2021.03.15.435419
Autor:
Alejandro Brenes, Hao Jiang, Angus I. Lamond, Dalila Bensaddek, Harunori Yoshikawa, Jens L. Hukelmann, Bogdan Mirauta, Oliver Stegle, Daniel D Seaton
SummaryX chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals whereby genes from one X chromosome are repressed. Analysis of human induced pluripotent stem cell (iPSC) lines using proteomics, RNAseq and polysome profilin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e523d04663b75ab990d06efca51d63e6