Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jens Löber"'
Autor:
Matthias Münchhalfen, Richard Görg, Michael Haberl, Jens Löber, Jakob Willenbrink, Laura Schwarzt, Charlotte Höltermann, Christian Ickes, Leonard Hammermann, Jan Kus, Björn Chapuy, Andrea Ballabio, Sybille D. Reichardt, Alexander Flügel, Niklas Engels, Jürgen Wienands
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Ligation of the B cell antigen receptor (BCR) initiates humoral immunity. However, BCR signaling without appropriate co-stimulation commits B cells to death rather than to differentiation into immune effector cells. How BCR activation deplet
Externí odkaz:
https://doaj.org/article/d3d3f15046064c9eadb2e5e5e120d8db
Autor:
Florian Mayr, Vanessa Kruse, Dominik C. Fuhrmann, Sebastian Wolf, Jens Löber, Saed Alsouri, Nadia Paglilla, Kwang Lee, Björn Chapuy, Bernhard Brüne, Thorsten Zenz, Björn Häupl, Thomas Oellerich, Michael Engelke
Publikováno v:
Haematologica, Vol 109, Iss 5 (2023)
Burkitt lymphoma cells (BL) exploit antigen-independent tonic signals transduced by the B-cell antigen receptor (BCR) for their survival, but the molecular details of the rewired BL-specific BCR signal network remain unclear. A loss of function scree
Externí odkaz:
https://doaj.org/article/eb6fc5e965704a859663478837179230
Autor:
Uta M. Demel, Marlitt Böger, Schayan Yousefian, Corinna Grunert, Le Zhang, Paul W. Hotz, Adrian Gottschlich, Hazal Köse, Konstandina Isaakidis, Dominik Vonficht, Florian Grünschläger, Elena Rohleder, Kristina Wagner, Judith Dönig, Veronika Igl, Bernadette Brzezicha, Francis Baumgartner, Stefan Habringer, Jens Löber, Björn Chapuy, Carl Weidinger, Sebastian Kobold, Simon Haas, Antonia B. Busse, Stefan Müller, Matthias Wirth, Markus Schick, Ulrich Keller
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Activated SUMOylation is a hallmark of cancer. Starting from a targeted screening for SUMO-regulated immune evasion mechanisms, we identified an evolutionarily conserved function of activated SUMOylation, which attenuated the immunogenicity of tumor
Externí odkaz:
https://doaj.org/article/07797f9821104132ba3cea7f4918f2e9
Autor:
Jürgen Wienands, Matthias Münchhalfen, Richard Görg, Jens Löber, Jakob Willenbrink, Laura Schwarzt, Charlotte Höltermann, Björn Chapuy, Christian Ickes, Jan Kus, Niklas Engels
Ligation of the B cell antigen receptor (BCR) initiates humoral immunity. However, mere BCR signaling without subsequent co-stimulation by T cells commits B cells to death rather than to differentiation into immune effector cells. It remains mysterio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4935a12cda5fa6aafeae2398b6bddca
https://doi.org/10.21203/rs.3.rs-1975280/v1
https://doi.org/10.21203/rs.3.rs-1975280/v1
Autor:
Ashok Kumar Jayavelu, Sebastian Wolf, Florian Buettner, Gabriela Alexe, Björn Häupl, Federico Comoglio, Constanze Schneider, Carmen Doebele, Dominik C. Fuhrmann, Sebastian Wagner, Elisa Donato, Carolin Andresen, Anne C. Wilke, Alena Zindel, Dominique Jahn, Bianca Splettstoesser, Uwe Plessmann, Silvia Münch, Khali Abou-El-Ardat, Philipp Makowka, Fabian Acker, Julius C. Enssle, Anjali Cremer, Frank Schnütgen, Nina Kurrle, Björn Chapuy, Jens Löber, Sylvia Hartmann, Peter J. Wild, Ilka Wittig, Daniel Hübschmann, Lars Kaderali, Jürgen Cox, Bernhard Brüne, Christoph Röllig, Christian Thiede, Björn Steffen, Martin Bornhäuser, Andreas Trumpp, Henning Urlaub, Kimberly Stegmaier, Hubert Serve, Matthias Mann, Thomas Oellerich
Publikováno v:
Cancer Cell. 40:301-317.e12
Acute myeloid leukemia (AML) is an aggressive blood cancer with a poor prognosis. We report a comprehensive proteogenomic analysis of bone marrow biopsies from 252 uniformly treated AML patients to elucidate the molecular pathophysiology of AML in or
Publikováno v:
European journal of immunologyReferences. 50(12)
Antigen recognition by B-cell antigen receptors (BCRs) activates distinct intracellular signaling pathways that control the differentiation fate of activated B lymphocytes. BCR-proximal signaling enzymes comprise protein tyrosine kinases, phosphatase
Autor:
Uta M. Demel, Marlitt Böger, Schayan Yousefian, Corinna Grunert, Le Zhang, Paul W. Hotz, Adrian Gottschlich, Hazal Köse, Konstandina Isaakidis, Dominik Vonficht, Florian Grünschläger, Elena Rohleder, Kristina Wagner, Judith Dönig, Veronika Igl, Bernadette Brzezicha, Francis Baumgartner, Stefan Habringer, Jens Löber, Björn Chapuy, Carl Weidinger, Sebastian Kobold, Simon Haas, Antonia B. Busse, Stefan Müller, Matthias Wirth, Markus Schick, Ulrich Keller
Publikováno v:
J. Clin. Invest. 132:e152383 (2022)
The Journal of Clinical Investigations
The Journal of Clinical Investigations
Activated SUMOylation is a hallmark of cancer. Starting from a targeted screening for SUMO-regulated immune evasion mechanisms, we identified an evolutionarily conserved function of activated SUMOylation, which attenuated the immunogenicity of tumor