Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jens Harborth"'
Autor:
Bharat Majeti, Robiel Baclig, Wenbin Ying, Xiaoen Wang, Dhrubamitra Chatterjee, Hai Wang, Cima Cina, Jean-Pierre Clamme, J.-P. Jin, Jose Ibarra, Jennifer Daniels, Li Wang, Jens Harborth, James Chu, Zhihong O'Brien, James T. Lin
Publikováno v:
Cancer Research. 80:4060-4060
Pancreatic cancer is the third most common cause of death from cancer in the US. The disease has a poor prognosis with a five-year survival rate under 10%. Mutations in KRAS are driving tumor growth in about 95% of patients with pancreatic cancer. Cu
Autor:
Robiel Baclig, Sonya Zabludoff, Steven Fong, James Chu, Jean-Pierre Clamme, Li Wang, Wenbin Ying, Jose Ibarra, Jens Harborth, Zhihong O'Brien, Clayton Zhang, Haiqing Yin, Roger Adami, Jing Yu, Bharat Majeti
Publikováno v:
Cancer Research. 78:5917-5917
Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancers and KRAS mutation occurs in 25-30% of NSCLC. Therapeutics directly targeting KRAS mutant proteins are currently not available. We developed a novel siRNA therapeutic agains
Autor:
Wenbin Ying, Cima Cina, Zhihong O'Brien, J.-P. Jin, Nish Beltran-Raygoza, Jessica Xu, Sonya Zabludoff, Jens Harborth, Sang Jun Lee, Kwok Yin Tsang, Jiping Yao, Roger Adami
Publikováno v:
Cancer Research. 78:5918-5918
Lung cancer is the most common form of cancer worldwide and the leading cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers, and KRAS mutation occurs in 25-30% of NSCLC. However, to da
Autor:
Ivanka Toudjarska, Jürgen Soutschek, Vandana Sood, Kevin McClintock, Akin Akinc, Birgit Bramlage, Matthew N. Fedoruk, Timothy Racie, Adam Judge, Ian MacLachlan, Hans-Peter Vornlocher, Lorne R. Palmer, Lloyd Jeffs, Kieu Lam, Sumi Shanmugam, William Zedalis, Tracy Zimmermann, Ingo Röhl, Matthias John, Ed Yaworski, Jens Harborth, Amy C.H. Lee, Muthiah Manoharan, Stephan Seiffert, James Heyes, David Bumcrot, Amanda J. Wheat, Victor Koteliansky, Lubomir Nechev
Publikováno v:
Nature. 441:111-114
The opportunity to harness the RNA interference (RNAi) pathway to silence disease-causing genes holds great promise for the development of therapeutics directed against targets that are otherwise not addressable with current medicines. Although there
Publikováno v:
Experimental Cell Research
Patients with the autosomal dominant form of Emery-Dreifuss muscular dystrophy (EDMD) or familial partial lipodystrophy (FPLD) have specific mutations in the lamin A gene. Three such point mutations, G465D (FPLD), R482L, (FPLD), or R527P (EDMD), were
Publikováno v:
Journal of Cell Science
We report the first RNAi-induced phenotypes in mammalian cultured cells using RNA interference mediated by duplexes of 21-nt RNAs. The 21 gene products studied have different functions and subcellular localizations. Knockdown experiments monitored by
Publikováno v:
EMBO Journal
NuMA, a 238 kDa protein present in the nucleus during interphase, translocates to the spindle poles in mitosis. NuMA plays an essential role in mitosis, since microinjection of the NuMA SPN-3 monoclonal antibody causes mitotic arrest and micronuclei
Publikováno v:
Journal of Cell Science. 104:139-150
Several high molecular mass proteins which relocate from the interphase nucleus to the spindle poles during mitosis have been defined by antibodies. Microinjection experiments have shown that at least the antigen defined by SPN antibody plays a funct
Publikováno v:
Plant Physiology. 101:303-312
Plastids have been isolated from pea (Pisum sativum L.) roots with a high degree of purity and intactness. In these plastids, the activity of enzymes involved in carbohydrate metabolism have been analyzed and corrected for cytosolic contamination. Th
Publikováno v:
Current opinion in molecular therapeutics. 10(2)
RNA interference (RNAi) has rapidly advanced from a laboratory observation into a major area of research within biology and medicine. RNAi is triggered by short interfering RNAs (siRNAs) of between 19 and 21 nucleotides in length, which induces the t