Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jens H. Westhoff"'
Autor:
Jens H. Westhoff, Petrus J. Steenbergen, Laurent S. V. Thomas, Jana Heigwer, Thomas Bruckner, Ledean Cooper, Burkhard Tönshoff, Georg F. Hoffmann, Jochen Gehrig
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Despite widespread drug exposure, for example during gestation or in prematurely born children, organ-specific developmental toxicity of most drugs is poorly understood. Developmental and functional abnormalities are a major cause of kidney diseases
Externí odkaz:
https://doaj.org/article/0fe8e17202554fb7bf3447870d4c3a9a
Autor:
Maria Bartosova, David Ridinger, Iva Marinovic, Jana Heigwer, Conghui Zhang, Eszter Levai, Jens H. Westhoff, Franz Schaefer, Stefan Terjung, Georg Hildenbrand, Damir Krunic, Felix Bestvater, Michael Hausmann, Claus Peter Schmitt, Sotirios G. Zarogiannis
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8178 (2021)
Endothelial and epithelial barrier function is crucial for the maintenance of physiological processes. The barrier paracellular permeability depends on the composition and spatial distribution of the cell-to-cell tight junctions (TJ). Here, we provid
Externí odkaz:
https://doaj.org/article/9e0793dc74cf466d90fa9a4207ddebe7
Autor:
Petrus J. Steenbergen, Jana Heigwer, Gunjan Pandey, Burkhard Tönshoff, Jochen Gehrig, Jens H. Westhoff
Publikováno v:
Cells, Vol 9, Iss 5, p 1269 (2020)
Automated high-throughput workflows allow for chemical toxicity testing and drug discovery in zebrafish disease models. Due to its conserved structural and functional properties, the zebrafish pronephros offers a unique model to study renal developme
Externí odkaz:
https://doaj.org/article/b5707b8f21e84edca8bd592761bdf83e
Autor:
Claudia Muhle-Goll, Philipp Eisenmann, Burkhard Luy, Stefan Kölker, Burkhard Tönshoff, Alexander Fichtner, Jens H. Westhoff
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1187 (2020)
Acute kidney injury (AKI) in critically ill children and adults is associated with significant short- and long-term morbidity and mortality. As serum creatinine- and urine output-based definitions of AKI have relevant limitations, there is a persiste
Externí odkaz:
https://doaj.org/article/b804349bc98b4f148dc6920dade42240
Publikováno v:
Frontiers in Pediatrics, Vol 6 (2018)
Genetic disorders account for a wide range of renal diseases emerging during childhood and adolescence. Due to the utilization of modern biochemical and biomedical techniques, the number of identified disease-associated genes is increasing rapidly. M
Externí odkaz:
https://doaj.org/article/9511f86f8d044a5d8f8e01189f7cedc5
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1290 (2019)
The zebrafish is being increasingly used in biomedical research and drug discovery to conduct large-scale compound screening. However, there is a lack of accessible methodologies to enable automated imaging and scoring of tissue-specific phenotypes a
Externí odkaz:
https://doaj.org/article/29a0ddfdda7845a69b4c2ac53406e0ae
Publikováno v:
Dtsch Arztebl Int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4243a2f876e66bdf3518089d29f879
https://europepmc.org/articles/PMC9902889/
https://europepmc.org/articles/PMC9902889/
Autor:
Dominik Schöndorf, Karl Reiter, Dominic Lenz, Carola Schön, Matias Wagner, Heiko Brennenstuhl, Florian Gesenhues, Gajja S. Salomons, Matthias Griese, Jens H Westhoff, Elias Seidl, Tina Heinzmann, Marisa I. Mendes, Mirjam Stahl, Desirée E.C. Smith, Christian Staufner, Thomas Longerich, Holger Prokisch, Olaf Sommerburg
Publikováno v:
Pediatric pulmonology, 55(11), 3057-3066. Wiley-Liss Inc.
Pediatr. Pulmonol. 55, 3057-3066 (2020)
Pediatric Pulmonology, 55(11), 3057-3066. Wiley-Liss Inc.
Lenz, D, Stahl, M, Seidl, E, Schöndorf, D, Brennenstuhl, H, Gesenhues, F, Heinzmann, T, Longerich, T, Mendes, M I, Prokisch, H, Salomons, G S, Schön, C, Smith, D E C, Sommerburg, O, Wagner, M, Westhoff, J H, Reiter, K, Staufner, C & Griese, M 2020, ' Rescue of respiratory failure in pulmonary alveolar proteinosis due to pathogenic MARS1 variants ', Pediatric Pulmonology, vol. 55, no. 11, pp. 3057-3066 . https://doi.org/10.1002/ppul.25031
Pediatr. Pulmonol. 55, 3057-3066 (2020)
Pediatric Pulmonology, 55(11), 3057-3066. Wiley-Liss Inc.
Lenz, D, Stahl, M, Seidl, E, Schöndorf, D, Brennenstuhl, H, Gesenhues, F, Heinzmann, T, Longerich, T, Mendes, M I, Prokisch, H, Salomons, G S, Schön, C, Smith, D E C, Sommerburg, O, Wagner, M, Westhoff, J H, Reiter, K, Staufner, C & Griese, M 2020, ' Rescue of respiratory failure in pulmonary alveolar proteinosis due to pathogenic MARS1 variants ', Pediatric Pulmonology, vol. 55, no. 11, pp. 3057-3066 . https://doi.org/10.1002/ppul.25031
Background: Pulmonary alveolar proteinosis (PAP) is a heterogeneous condition with more than 100 different underlying disorders that need to be differentiated to target therapeutic options, which are generally limited. Methods: The clinical course of
Autor:
Thomas Opladen, Heiko Brennenstuhl, Oya Kuseyri Hübschmann, Debora Call, Kim Green, Ulrike Schara, Wolfgang Rascher, Annegret Hövel, Birgit Assmann, Stefan Kölker, Jens H. Westhoff, Magdalena Walter, Andreas Ziegler, Georg F. Hoffmann, Karl Kiening
in press
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d581de85bbb1141b71625cd7f5332913
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85138933356
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85138933356
Autor:
Stefan Kölker, Heiko Brennenstuhl, Ulrike Schara, Andreas Ziegler, Karl L. Kiening, Kim Green, Annegret Hövel, Jens H Westhoff, Birgit Assmann, Thomas Opladen, Magdalena Walter, Oya Kuseyri Hübschmann, Debora Call, Wolfgang Rascher, Georg F. Hoffmann
Hintergrund Der autosomal-rezessiv vererbte Defekt der aromatischen L‑Aminosäure-Decarboxylase (AADC) führt zu einem ausgeprägten, kombinierten Mangel an Dopamin, Serotonin und Katecholaminen. Das klinische Bild ist charakterisiert durch eine ru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dffed0f05f491c43a78b46fdf461327
https://opus4.kobv.de/opus4-fau/files/22141/s00112-021-01232-7.pdf
https://opus4.kobv.de/opus4-fau/files/22141/s00112-021-01232-7.pdf