Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Jens H Gundlach"'
A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury
Autor:
Christopher Whidbey, Jay Vornhagen, Claire Gendrin, Erica Boldenow, Jenny Mae Samson, Kenji Doering, Lisa Ngo, Ejiofor A D Ezekwe, Jens H Gundlach, Michal A Elovitz, Denny Liggitt, Joseph A Duncan, Kristina M Adams Waldorf, Lakshmi Rajagopal
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 4, Pp 488-505 (2015)
Abstract Group B streptococci (GBS) are Gram‐positive bacteria that cause infections in utero and in newborns. We recently showed that the GBS pigment is hemolytic and increased pigment production promotes bacterial penetration of human placenta. H
Externí odkaz:
https://doaj.org/article/58cc3b802639472a95d79fdb5dca6df9
Autor:
Ian C Nova, Ian M Derrington, Jonathan M Craig, Matthew T Noakes, Benjamin I Tickman, Kenji Doering, Hugh Higinbotham, Andrew H Laszlo, Jens H Gundlach
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181599 (2017)
Nanopore DNA sequencing is a promising single-molecule analysis technology. This technique relies on a DNA motor enzyme to control movement of DNA precisely through a nanopore. Specific experimental buffer conditions are required based on the preferr
Externí odkaz:
https://doaj.org/article/560b97e04cbb4d4a8f44a96e86638980
Autor:
Jonathan M Craig, Andrew H Laszlo, Ian M Derrington, Brian C Ross, Henry Brinkerhoff, Ian C Nova, Kenji Doering, Benjamin I Tickman, Mark T Svet, Jens H Gundlach
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143253 (2015)
Malyshev et al. showed that the four-letter genetic code within a living organism could be expanded to include the unnatural DNA bases dNaM and d5SICS. However, verification and detection of these unnatural bases in DNA requires new sequencing techni
Externí odkaz:
https://doaj.org/article/03ee6b8236104b3db7ba60539f25f146
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38726 (2012)
Mycobacterium smegmatis porin A (MspA) forms an octameric channel and represents the founding member of a new family of pore proteins. Control of subunit stoichiometry is important to tailor MspA for nanotechnological applications. In this study, two
Externí odkaz:
https://doaj.org/article/8c9a2a71ca6f4a00bde02dda66b9b44f
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25723 (2011)
Nanopore sequencing has the potential to become a fast and low-cost DNA sequencing platform. An ionic current passing through a small pore would directly map the sequence of single stranded DNA (ssDNA) driven through the constriction. The pore protei
Externí odkaz:
https://doaj.org/article/dd370ea14da343c69a6dccddfc3aa59e
Autor:
Jonathan M Craig, Maria Mills, Hwanhee C Kim, Jesse R Huang, Sarah J Abell, Jonathan W Mount, Jens H Gundlach, Keir C Neuman, Andrew H Laszlo
Publikováno v:
Nucleic Acids Research. 50:10601-10613
Helicases are essential for nearly all nucleic acid processes across the tree of life, yet detailed understanding of how they couple ATP hydrolysis to translocation and unwinding remains incomplete because their small (∼300 picometer), fast (∼1 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680fb19d5356eb163f2d0420fa5a135f
https://doi.org/10.1093/nar/gkac837
https://doi.org/10.1093/nar/gkac837
Autor:
Christopher A. Thomas, Jonathan M. Craig, Shuichi Hoshika, Henry Brinkerhoff, Jesse R. Huang, Sarah J. Abell, Hwanhee C. Kim, Michaela C. Franzi, Jessica D. Carrasco, Hyo-Joong Kim, Drew C. Smith, Jens H. Gundlach, Steven A. Benner, Andrew H. Laszlo
Publikováno v:
Journal of the American Chemical Society.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9faf73fad61ffb8c68e33e8876c2ea05
https://doi.org/10.1021/jacs.3c00829
https://doi.org/10.1021/jacs.3c00829
Autor:
Alan Shaw, Jonathan M. Craig, Hossein Amiri, Jeonghoon Kim, Heather E. Upton, Sydney C. Pimentel, Jesse R. Huang, Susan Marqusee, Jens H. Gundlach, Kathleen Collins, Carlos J. Bustamante
Techniques that can directly sequence RNAs and determine secondary structures are essential to establish how an RNA molecule folds and how folding affects its function. We describe the development of a direct RNA nanopore sequencing technique using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aaa4a7f0575975f04797cedb8dcba36
https://doi.org/10.1101/2023.04.05.535757
https://doi.org/10.1101/2023.04.05.535757
Autor:
Ian C. Nova, Justas Ritmejeris, Henry Brinkerhoff, Theo J. R. Koenig, Jens H. Gundlach, Cees Dekker
Current methods to detect post-translational modifications (PTMs) of proteins, such as phosphate groups, cannot measure single molecules and often cannot differentiate between closely spaced phosphorylation sites. Using a nanopore sequencing approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94283b501b265c6b4d51e6c35923343d
https://doi.org/10.1101/2022.11.11.516163
https://doi.org/10.1101/2022.11.11.516163
Autor:
Sinduja K. Marx, Keith J. Mickolajczyk, Jonathan M. Craig, Christopher A. Thomas, Akira M. Pfeffer, Sarah J. Abell, Jessica D. Carrasco, Michaela C. Franzi, Jesse R. Huang, Hwanhee C. Kim, Henry D. Brinkerhoff, Tarun M. Kapoor, Jens H. Gundlach, Andrew H. Laszlo
Publikováno v:
bioRxiv : the preprint server for biology.
The genome of SARS-CoV-2 encodes for a helicase called nsp13 that is essential for viral replication and highly conserved across related viruses, making it an attractive antiviral target. Here we use nanopore tweezers, a high-resolution single-molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ac5eeb6c8305d406edbe3e8fe0302f
https://pubmed.ncbi.nlm.nih.gov/36238723
https://pubmed.ncbi.nlm.nih.gov/36238723