Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jens Füllgrabe"'
Autor:
Patricia González-Rodríguez, Elizabeth Delorme-Axford, Amélie Bernard, Lily Keane, Vassilis Stratoulias, Kathleen Grabert, Pinelopi Engskog-Vlachos, Jens Füllgrabe, Daniel J. Klionsky, Bertrand Joseph
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-13 (2022)
Abstract Macroautophagy/autophagy is an evolutionarily conserved and tightly regulated catabolic process involved in the maintenance of cellular homeostasis whose dysregulation is implicated in several pathological processes. Autophagy begins with th
Externí odkaz:
https://doaj.org/article/0b1a1d3b4425414c99ff9cf57348ae04
Autor:
Nicolas J. Walker, Mamunur Rashid, Shirong Yu, Helen Bignell, Casper K. Lumby, Carmen M. Livi, Kate Howell, David J. Morley, Sandro Morganella, Daniel Barrell, Shabhonam Caim, Walraj Gosal, Jens Füllgrabe, Thomas J. Charlesworth, Louella Vasquez, Miika Ahdesmäki, Jordan Eizenga, Parul Prabhat, Vitali Proutski, Marie Laurie Murat-Onana, Catherine J. Greenwood, Lisa Kirkwood, Meeta Maisuria-Armer, Mengjie Li, Emma Coats, Victoria Winfield, Lachlan MacBean, Toby Stock, Alice Tomé-Fernandez, Yat Chan, Nasir Sheikh, Paula Golder, Michael Steward, Tobias W. B. Ost, Douglas Stewart, Albert Vilella, Mojtaba Noursalehi, Benedict Paten, Debora Lucarelli, Joanne Mason, Gareth Ridge, Jason Mellad, Suman Shirodkar, Shankar Balasubaramanian, Joanna D. Holbrook
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Early detection of cancer will improve survival rates. The blood biomarker 5-hydroxymethylcytosine has been shown to discriminate cancer. In a large covariate-controlled study of over two thousand individual blood samples, we created, tested
Externí odkaz:
https://doaj.org/article/d0f8987336da4809bf0d43cd15a3ea02
Autor:
Mariana Pavel, Maurizio Renna, So Jung Park, Fiona M. Menzies, Thomas Ricketts, Jens Füllgrabe, Avraham Ashkenazi, Rebecca A. Frake, Alejandro Carnicer Lombarte, Carla F. Bento, Kristian Franze, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
At high cell density or when plated on soft matrix, YAP/TAZ are redistributed from the nucleus to the cytosol, becoming transcriptionally inactive. Here the authors show that at high cell density, autophagosome formation is impaired due to reduced YA
Externí odkaz:
https://doaj.org/article/0cc58f26136b45e7a5358ff2da4265a7
Autor:
Jens Füllgrabe, Walraj S. Gosal, Páidí Creed, Sidong Liu, Casper K. Lumby, David J. Morley, Tobias W. B. Ost, Albert J. Vilella, Shirong Yu, Helen Bignell, Philippa Burns, Tom Charlesworth, Beiyuan Fu, Howerd Fordham, Nicolas J. Harding, Olga Gandelman, Paula Golder, Christopher Hodson, Mengjie Li, Marjana Lila, Yang Liu, Joanne Mason, Jason Mellad, Jack M. Monahan, Oliver Nentwich, Alexandra Palmer, Michael Steward, Minna Taipale, Audrey Vandomme, Rita Santo San-Bento, Ankita Singhal, Julia Vivian, Natalia Wójtowicz, Nathan Williams, Nicolas J. Walker, Nicola C. H. Wong, Gary N. Yalloway, Joanna D. Holbrook, Shankar Balasubramanian
Publikováno v:
Nature Biotechnology.
DNA comprises molecular information stored in genetic and epigenetic bases, both of which are vital to our understanding of biology. Most DNA sequencing approaches address either genetics or epigenetics and thus capture incomplete information. Method
Autor:
Jens Füllgrabe, Walraj S Gosal, Páidí Creed, Sidong Liu, Casper K Lumby, David J Morley, Tobias W B Ost, Albert J Vilella, Shirong Yu, Helen Bignell, Philippa Burns, Tom Charlesworth, Beiyuan Fu, Howerd Fordham, Nick Harding, Olga Gandelman, Paula Golder, Christopher Hodson, Mengjie Li, Marjana Lila, Yang Liu, Joanne Mason, Jason Mellad, Jack Monahan, Oliver Nentwich, Alexandra Palmer, Michael Steward, Minna Taipale, Audrey Vandomme, Rita Santo San-Bento, Ankita Singhal, Julia Vivian, Natalia Wójtowicz, Nathan Williams, Nicolas J Walker, Nicola C H Wong, Gary Yalloway, Joanna D Holbrook, Shankar Balasubaramanian
DNA comprises molecular information stored via genetic bases (G, C, T, A) and also epigenetic bases, principally 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). Both genetic and epigenetic information are vital to our understanding of biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac2af7acf13559572475f1c21b6cbf27
https://doi.org/10.1101/2022.07.08.499285
https://doi.org/10.1101/2022.07.08.499285
Autor:
Fabio Puddu, Casper K. Lumby, Nick Harding, David J. Morley, Jamie Scotcher, Robert Crawford, Jens Füllgrabe, Walraj S. Gosal, Shirong Yu, Daniel Brudzewsky, Jane Haywood, Andrada Tomoni, Philippa Burns, Joanna D. Holbrook, Paidi Creed
Publikováno v:
Cancer Research. 83:6602-6602
Liquid biopsy for profiling of cell free DNA (cfDNA) in blood holds huge promise to transform how we experience and manage cancer by early detection and identification of residual disease and subtype. However, a standard blood draw yields an average
Autor:
Patricia González-Rodríguez, Kristian Dreij, Agata Lupa, Virginia Cunha, Mathilde Cheray, Maria Salli, Lily Keane, Michael G. Rosenfeld, Pinelopi Engskog-Vlachos, Bertrand Joseph, Wenbo Li, Qi Ma, Jens Füllgrabe
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Macroautophagy/autophagy is a conserved catabolic pathway that targets cytoplasmic components for their degradation and recycling in an autophagosome-dependent lysosomal manner. Under physiological conditions, this process maintains cellular homeosta
Autor:
Stephen P. Andrews, Avraham Ashkenazi, Veerle Baekelandt, Jeremy D. Baker, Konrad Beyreuther, Laura J. Blair, Azad Bonni, Erin Bove-Fenderson, Patrik Brundin, Andrea Caricasole, Amarallys F. Cintron, Mark R. Cookson, Utpal Das, Sarah M. de Jager, Maria E. de Sousa Rodrigues, Audrey S. Dickey, Chad A. Dickey, Cheng Fang, Angeleen Fleming, Jens Füllgrabe, Stephen K. Godin, Michel Goedert, Lawrence S. Goldstein, Jorge Gomez-Deza, Ben Gu, David A. Harris, Harm H. Kampinga, Scott Koppel, John Koren, Albert R. La Spada, Simon Laws, Floriana Licitra, Yen Y. Lim, Ana Lopez, Kathryn P. MacPherson, Colin L. Masters, Alex J. McDonald, Robert C.C. Mercer, Mariana Pavel, Wouter Peelaerts, Leonard Petrucelli, Claudia Puri, Maurizio Renna, Thomas Ricketts, Blaine Roberts, David C. Rubinsztein, Jinsoo Seo, Christopher E. Shaw, Lindsey B. Shelton, John Skidmore, Sarah E. Smith, Russell H. Swerdlow, Malú G. Tansey, Tiffany W. Todd, Li-Huei Tsai, Vladimir N. Uversky, Fred W. van Leeuwen, Mariella Vicinanza, Victor L. Villemagne, Alex von Schulze, Xiaowan Wang, Jack M. Webster, Ian Weidling, Heather M. Wilkins, Michael S. Wolfe, Bei Wu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e518906b4e18d6ed54ce87b37749b142
https://doi.org/10.1016/b978-0-12-811304-2.00026-2
https://doi.org/10.1016/b978-0-12-811304-2.00026-2
Autor:
Jens Füllgrabe, Steven K. Backues, Bertrand Joseph, Patricia González-Rodríguez, Meiyan Jin, Amélie Bernard, Elizabeth Delorme-Axford, Daniel J. Klionsky
Publikováno v:
Current Biology. 25:546-555
Summary Background Autophagy is a conserved process mediating vacuolar degradation and recycling. Autophagy is highly upregulated upon various stresses and is essential for cell survival in deleterious conditions. Autophagy defects are associated wit
Autor:
Fiona M. Menzies, Jens Füllgrabe, Maurizio Renna, Mariella Vicinanza, Maria Jimenez Sanchez, Avraham Ashkenazi, Andrea Caricasole, Hyeran Won, Ye Zhu, Mariana Pavel, Cansu Karabiyik, Claudia Puri, Floriana Licitra, Carla F. Bento, Ana Lopez Ramirez, Thomas Ricketts, Angeleen Fleming, David C. Rubinsztein, Lars Schlotawa, Anne Jackson, Stephen P. Andrews, John Skidmore
Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review evidence from mouse knockout studies demonstrating the normal functions of autop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ca4b057ec64a50ebc04380d4932e7b
https://www.repository.cam.ac.uk/handle/1810/263493
https://www.repository.cam.ac.uk/handle/1810/263493