Improved leptin sensitivity and increased soluble leptin receptor concentrations may underlie the additive effects of combining PYY [1–34] and exendin-4 on body weight lowering in diet-induced obese mice

Autor: Birgitte S. Wulff, Rune Ehrenreich Kuhre, Madhan Selvaraj, Jens F. Rehfeld, Kristoffer Niss, Johannes J. Fels, Secher Anna, Kirsten Raun, Marina Kjaergaard Gerstenberg

Publikováno v: Heliyon, Vol 10, Iss 12, Pp e32009- (2024)

Objective: Co-treatment with long acting PYY and the GLP-1 receptor agonists has potential as an efficient obesity treatment. This study investigates whether the mechanisms behind additive reduction of food intake and weight loss depends on complemen

Externí odkaz: https://doaj.org/article/4c1a17d3a0794a50bafbe1ca28b42027

Enterohepatic, Gluco-metabolic, and Gut Microbial Characterization of Individuals With Bile Acid Malabsorption

Autor: Martin L. Kårhus, David P. Sonne, Martin Thomasen, Anne-Marie Ellegaard, Jens J. Holst, Jens F. Rehfeld, Oscar Chávez-Talavera, Anne Tailleux, Bart Staels, Dennis S. Nielsen, Lukasz Krych, Lars O. Dragsted, Tina Vilsbøll, Andreas Brønden, Filip K. Knop

Publikováno v: Gastro Hep Advances, Vol 1, Iss 3, Pp 299-312 (2022)

Background and Aims: Bile acid malabsorption (BAM) is a debilitating disease characterized by loose stools and high stool frequency. The pathophysiology of BAM is not well-understood. We investigated postprandial enterohepatic and gluco-metabolic phy

Externí odkaz: https://doaj.org/article/f76919d4a1ab4a769b0d39a75d0aa3b1

Sacubitril/valsartan increases postprandial gastrin and cholecystokinin in plasma

Autor: Ulrik Ø Andersen, Dijana Terzic, Nicolai Jacob Wewer Albrechtsen, Peter Dall Mark, Peter Plomgaard, Jens F Rehfeld, Finn Gustafsson, Jens P Goetze

Publikováno v: Endocrine Connections, Vol 9, Iss 5, Pp 438-444 (2020)

Aims: Neprilysin degrades natriuretic peptides in circulation and is also suggested to degrade the gut hormones gastrin and cholecystokinin. Neprilysin inhibition has become a therapeutic strategy and thus a regimen in need of further testing in term

Externí odkaz: https://doaj.org/article/e6fa5c4b127a4465b5921d4cb30c2447

Liraglutide changes postprandial responses of gut hormones involved in the regulation of gallbladder motility

Autor: Henriette H. Nerild, Andreas Brønden, Ida M. Gether, Pernille H. Hellmann, Mille Baekdal, Matthew P. Gillum, Jens S. Svenningsen, Bolette Hartmann, Naveen Rathor, Hanna Angelene Kudiyanur Muniraju, Jens F. Rehfeld, Jens J. Holst, Tina Vilsbøll, David P. Sonne, Filip K. Knop

Publikováno v: Nerild, H H, Brønden, A, Gether, I M, Hellmann, P H, Baekdal, M, Gillum, M P, Svenningsen, J S, Hartmann, B, Rathor, N, Kudiyanur Muniraju, H A, Rehfeld, J F, Holst, J J, Vilsbøll, T, Sonne, D P & Knop, F K 2023, ' Liraglutide changes postprandial responses of gut hormones involved in the regulation of gallbladder motility ', Diabetes, Obesity and Metabolism, vol. 25, no. 6, pp. 1632-1637 . https://doi.org/10.1111/dom.15017

AIM: Liraglutide treatment is associated with gallbladder-related disorders and has been shown to delay postprandial gallbladder refilling. The gut hormones cholecystokinin (CCK), fibroblast growth factor 19 (FGF19) and glucagon-like peptide 2 (GLP-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23324ec7c1b97914e173df0b499a96d6
https://doi.org/10.1111/dom.15017

Cholecystokinin and the hormone concept

Autor: Jens F Rehfeld

Publikováno v: Endocrine Connections, Vol 10, Iss 3, Pp R139-R150 (2021)

The birth certificate for endocrinology was Bayliss’ and Starlin g’s demonstration in 1902 that regulation of bodily functions is not only neuronal but al so due to blood-borne messengers. Starling named these messengers hormones. Since the n tra

Externí odkaz: https://doaj.org/article/e7998749cb7b43969f50007bd2429adf