A Thermal Exhaust Port on the Death Star of Plasmodium falciparum-Infected Erythrocytes

Autor: Jens E.V. Petersen, Steve M. Taylor

Publikováno v: Trends in Pharmacological Sciences. 41:508-511

Eliciting reliable and effective immunity against Plasmodium falciparum parasites remains an elusive goal in malaria control. Raj and colleagues recently described a naturally occurring human antibody response to a parasite antigen that initiates apo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5edd8ff8e80890c734ed107a27973c08
https://doi.org/10.1016/j.tips.2020.06.005

Impact of Sickle Cell Trait Hemoglobin on the Intraerythrocytic Transcriptional Program of Plasmodium falciparum

Autor: Jens E.V. Petersen, Steven B. Haase, Joseph W. Saelens, Karim Traore, Drissa Konaté, Rick M. Fairhurst, Steve M. Taylor, Elizabeth Freedman, Natalie Vance, Robert C. Moseley, Seidina A. S. Diakite, Mahamadou Diakite

Publikováno v: mSphere, Vol 6, Iss 5 (2021)
mSphere

Sickle-trait hemoglobin (HbAS) confers nearly complete protection from severe, life-threatening falciparum malaria in African children. Despite this clear protection, the molecular mechanisms by which HbAS confers these protective phenotypes remain i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c9fca89af98f5add08578e77d71020
https://journals.asm.org/doi/10.1128/mSphere.00755-21

Developing and validating COVID-19 adverse outcome risk prediction models from a bi-national European cohort of 5594 patients

Autor: Akshay Pai, Jens E.V. Petersen, Benjamin Skov Kaas-Hansen, Marie Helleberg, Matilde Winther-Jensen, Andreas David Lauritzen, Raghavendra Selvan, Gert Mehl Virenfeldt, Stine Hasling Mogensen, Mads Nielsen, Martin Erik Nyeland, Mikkel Bonde, Martin Sillesen, Hans-Christian Thorsen-Meyer, Janne Petersen, Martin Lillholm, Casper Worm Hansen, Christian Igel, Christina Lioma, Bulat Ibragimov, Anders Perner, Stephan Sloth Lorenzen, Mikkel Zöllner Ankarfeldt, Jon Middleton, Allan Linneberg, Espen Jimenez-Solem, Alexander Bonde, Abraham George Smith, Oswin Krause, Christian Hansen, Tonny Studsgaard Petersen, Mostafa Mehdipour Ghazi, Marleen de Bruijne, Nicki Skafte Detlefsen, Wouter Boomsma

Publikováno v: Jimenez-Solem, E, Petersen, T S, Hansen, C, Hansen, C, Lioma, C, Igel, C, Boomsma, W, Krause, O, Lorenzen, S, Selvan, R, Petersen, J, Nyeland, M E, Ankarfeldt, M Z, Virenfeldt, G M, Winther-Jensen, M, Linneberg, A, Ghazi, M M, Detlefsen, N, Lauritzen, A D, Smith, A G, de Bruijne, M, Ibragimov, B, Petersen, J, Lillholm, M, Middleton, J, Mogensen, S H, Thorsen-Meyer, H-C, Perner, A, Helleberg, M, Kaas-Hansen, B S, Bonde, M, Bonde, A, Pai, A, Nielsen, M & Sillesen, M 2021, ' Developing and validating COVID-19 adverse outcome risk prediction models from a bi-national European cohort of 5594 patients ', Scientific Reports, vol. 11, no. 1, 3246 . https://doi.org/10.1038/s41598-021-81844-x
Scientific Reports
Scientific Reports, 11(1):3246. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

BackgroundPatients with severe COVID-19 have overwhelmed healthcare systems worldwide. We hypothesized that Machine Learning (ML) models could be used to predict risks at different stages of management (at diagnosis, hospital admission and ICU admiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117f1461ebfa27f17f0ee84b99854782
https://curis.ku.dk/ws/files/256879260/Developing_and_validating_COVID_19_adverse_outcome_risk_prediction_models_from_a_bi_national_European_cohort_of_5594_patients.pdf

Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1

Autor: Steven B. Mwakalinga, Christian W. Wang, Jens E.V. Petersen, John Lusingu, Sixbert I. Mkumbaye, Eric Lyimo, Alphaxard Manjurano, Thor G. Theander, Jacklin F. Mosha, Anna V. Vaaben, Thomas Lavstsen, Daniel T. R. Minja, Reginald A. Kavishe

Publikováno v: Scientific Reports
Petersen, J E V, Mkumbaye, S I, Vaaben, A V, Manjurano, A, Lyimo, E, Kavishe, R A, Mwakalinga, S B, Mosha, J, Minja, D T R, Lusingu, J P A, Theander, T G, Lavstsen, T & Wang, C W 2016, ' Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1 ', Scientific Reports, vol. 6, 35950 . https://doi.org/10.1038/srep35950

The pathogenesis of Plasmodium falciparum malaria involves a complex interplay between parasite adhesion and inflammatory response that includes release of cytokines and activation of the endothelium with accompanying release of Angiopoitin 2 (Ang2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579dedcaba13ed52563145881ae87fdb

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

Autor: Daniel T. R. Minja, Louise Turner, Thor G. Theander, Sixbert I. Mkumbaye, Jens E.V. Petersen, Thomas Lavstsen, John Lusingu, Jakob S. Jespersen, Bent O. Petersen, Christian W. Wang

Publikováno v: EMBO Molecular Medicine
Jespersen, J S, Wang, C W, Mkumbaye, S I, Minja, D T, Petersen, B, Turner, L, Petersen, J E, Lusingu, J P, Theander, T G & Lavstsen, T 2016, ' Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains ', EMBO Molecular Medicine, vol. 8, no. 8, pp. 839-850 . https://doi.org/10.15252/emmm.201606188
Jespersen, J S, Wang, C W, Mkumbaye, S I, Minja, D T R, Petersen, B, Turner, L, Petersen, J E V, Lusingu, J P A, Theander, T G & Lavstsen, T 2016, ' Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains ', EMBO Molecular Medicine, vol. 8, no. 7, pp. 685-829 . https://doi.org/10.15252/emmm.201606188

Most severe Plasmodium falciparum infections are experienced by young children. Severe symptoms are precipitated by vascular sequestration of parasites expressing a particular subset of the polymorphic P. falciparum erythrocyte membrane protein 1 (Pf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347dc8666e45d74179f55259d3a293b4
https://pubmed.ncbi.nlm.nih.gov/27354391