Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jens Derbinski"'
Publikováno v:
Genomics Data, Vol 6, Iss C, Pp 48-50 (2015)
The establishment of central tolerance essentially depends on the promiscuous gene expression (pGE) of a plethora of tissue restricted antigens by the medullary thymic epithelial cells. The antigens are presented to developing thymocytes in the thymu
Externí odkaz:
https://doaj.org/article/488a3a0698ff4a2ca881d3930574fb37
Autor:
Liliana E. Lucca, Jens Derbinski, Nicolas Fazilleau, Pierre Rufas, Abdulraouf Ramadan, Roland S. Liblau, Bruno Kyewski, Corine Perals, Lennart T. Mars, Pierre Paul Axisa, Meryem Aloulou
Publikováno v:
European Journal of Immunology
European Journal of Immunology, 2016, 46 (9), pp.2247-2259. ⟨10.1002/eji.201646416⟩
European Journal of Immunology, Wiley-VCH Verlag, 2016, 46 (9), pp.2247-2259. ⟨10.1002/eji.201646416⟩
European Journal of Immunology, 2016, 46 (9), pp.2247-2259. ⟨10.1002/eji.201646416⟩
European Journal of Immunology, Wiley-VCH Verlag, 2016, 46 (9), pp.2247-2259. ⟨10.1002/eji.201646416⟩
T-cell polyspecificity, predicting that individual T cells recognize a continuum of related ligands, implies that multiple antigens can tolerize T cells specific for a given self-antigen. We previously showed in C57BL/6 mice that part of the CD4(+) T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcdd29813219237280c7a3b82fae6c6
https://doi.org/10.1002/eji.201646416
https://doi.org/10.1002/eji.201646416
Autor:
Thorsten Marquardt, Jochen Meyburg, Anibh M. Das, Georg F. Hoffmann, Thomas Opladen, Barbara K. Burton, Kathrin Zangerl, Sukru Emre, Aneal Khan, Sebene Mayorandan, Thea Böhm, Bernd Rosenkranz, Peter Burgard, Bruce A. Barshop, Jörg Rennecke, Martin Lindner, Jens Derbinski, Ulrich H.N. Dürr, Marc Yudkoff
Publikováno v:
Molecular Genetics and Metabolism. 117:19-26
Background The hepatic urea cycle is the main metabolic pathway for detoxification of ammonia. Inborn errors of urea cycle function present with severe hyperammonemia and a high case fatality rate. Long-term prognosis depends on the residual activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdaa34bc0982c15ee45f303554ad9b1
https://doi.org/10.1016/j.ymgme.2015.11.007
https://doi.org/10.1016/j.ymgme.2015.11.007
Publikováno v:
Genomics Data, Vol 6, Iss C, Pp 48-50 (2015)
Genomics Data
Genomics Data
The establishment of central tolerance essentially depends on the promiscuous gene expression (pGE) of a plethora of tissue restricted antigens by the medullary thymic epithelial cells. The antigens are presented to developing thymocytes in the thymu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c3d2a7ce7c7bd9e24f0044398a1640
Autor:
Eva Thimm, Jörg Rennecke, Vassili Valayannopoulos, Jens Derbinski, Sebene Mayorandan, Pascale de Lonlay, Anibh M. Das, Vassiliki Konstantopoulou, Skadi Beblo, Caroline Unsinn, Alberto Burlina, Georg F. Hoffmann, Johannes Häberle
Publikováno v:
Orphanet Journal of Rare Diseases
Orphanet journal of rare diseases
Orphanet journal of rare diseases
Background Urea cycle disorders (UCDs) are rare inherited metabolic defects of ammonia detoxification. In about half of patients presenting with a UCD, the first symptoms appear within a few days after birth. These neonatal onset patients generally h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eace6cde9731edd4f260e0eab03c3885
http://europepmc.org/articles/PMC4991093
http://europepmc.org/articles/PMC4991093
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 196(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2f13ac12bbbf214c1261345fabe28f5
https://pubmed.ncbi.nlm.nih.gov/26994302
https://pubmed.ncbi.nlm.nih.gov/26994302
Autor:
Jens Derbinski, Bruno Kyewski
Publikováno v:
Current Opinion in Immunology. 22:592-600
Our perception of the scope self-antigen availability for tolerance induction in the thymus has profoundly changed over the recent years following new insights into the cellular and molecular complexity of intrathymic antigen presentation. The divers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e532faa424b814eb2cefef3c16c096f2
https://doi.org/10.1016/j.coi.2010.08.003
https://doi.org/10.1016/j.coi.2010.08.003
Publikováno v:
Proceedings of the National Academy of Sciences. 105:657-662
Promiscuous expression of tissue-restricted autoantigens in medullary thymic epithelial cells (mTECs) imposes central T cell tolerance. The molecular regulation of this unusual gene expression is not understood, in particular its delineation from cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4054052ee86818f40e8a10740f41a8aa
https://doi.org/10.1073/pnas.0707486105
https://doi.org/10.1073/pnas.0707486105
Autor:
Bruno Kyewski, Sonja Matt, Kristin Rattay, Janine Claude, Esmail Rezavandy, Jens Derbinski, Thomas G. Hofmann
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 194(3)
Promiscuous expression of a plethora of tissue-restricted Ags (TRAs) by medullary thymic epithelial cells (mTECs) plays an essential role in T cell tolerance. Although the cellular mechanisms by which promiscuous gene expression (pGE) imposes T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0405867650f7b66a9e6eba6bd7b97203
https://pubmed.ncbi.nlm.nih.gov/25552543
https://pubmed.ncbi.nlm.nih.gov/25552543
Autor:
Bruno Kyewski, Jens Derbinski
Publikováno v:
Trends in Immunology. 26:503-506
Medullary thymic epithelial cells (mTECs) are indispensable for self-tolerance to peripheral organs by virtue of their expression of a host of tissue-restricted self-antigens. The full extent of this promiscuous gene expression is confined to functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0daac34db6376c85584b358e97ad687b
https://doi.org/10.1016/j.it.2005.07.006
https://doi.org/10.1016/j.it.2005.07.006