Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jens C. Krause"'
Autor:
Jens C. Krause, Damian C. Ekiert, Terrence M. Tumpey, Patricia B. Smith, Ian A. Wilson, James E. Crowe
Publikováno v:
mBio, Vol 2, Iss 1 (2011)
ABSTRACT The structural and functional significance of somatic insertions and deletions in antibody chains is unclear. Here, we demonstrate that a naturally occurring three-amino-acid insertion within the influenza virus-specific human monoclonal ant
Externí odkaz:
https://doaj.org/article/048e786b5ef74f1bacc5e4ca0983aec7
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43603 (2012)
Recently, a new class of broadly neutralizing anti-influenza virus antibodies that target the stalk domain of the viral hemagglutinin was discovered. As such, induction, isolation, characterization, and quantification of these novel antibodies has be
Externí odkaz:
https://doaj.org/article/f949c0c6d0014ab9bcf9c3a9e151cdad
Autor:
Tshidi Tsibane, Damian C Ekiert, Jens C Krause, Osvaldo Martinez, James E Crowe, Ian A Wilson, Christopher F Basler
Publikováno v:
PLoS Pathogens, Vol 8, Iss 12, p e1003067 (2012)
Most monoclonal antibodies (mAbs) to the influenza A virus hemagglutinin (HA) head domain exhibit very limited breadth of inhibitory activity due to antigenic drift in field strains. However, mAb 1F1, isolated from a 1918 influenza pandemic survivor,
Externí odkaz:
https://doaj.org/article/9a7af32a8fc34cd6a6116ac08c903da4
Publikováno v:
Nature Structural & Molecular Biology. 20:363-370
Influenza virus hemagglutinin (HA) mediates receptor binding and viral entry during influenza infection. The development of receptor analogs as viral-entry blockers has not been successful, which suggests that sialic acid may not be an ideal scaffold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e76587a2558adf69a226df5d44bef4
https://doi.org/10.1038/nsmb.2500
https://doi.org/10.1038/nsmb.2500
Autor:
Romina Libster, Elsa Baumeister, Bernardo Maskin, Jennifer M. Klemenc, Kathryn M. Edwards, Marcela Echavarria, Jens C. Krause, M Florencia Lopez, Guillermina A. Melendi, Ana Clara Monsalvo, Carlos Rubinstein, Jimena Bugna, Liliana Solari, James E. Crowe, Graciela Cabral, Joyce E. Johnson, Vilma Savy, Liliana Dalurzo, Juan P. Batalle, Fernando P. Polack, Kevin P. Weller, Julia Font, John V. Williams, Leandro Aguilar, James D. Chappell, Johanna Zea Hernandez, Liliana Aguilar
Publikováno v:
Nature medicine
Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da25279b84f93456cc27ff5f1ae59ab4
https://doi.org/10.1038/nm.2262
https://doi.org/10.1038/nm.2262
Autor:
Jens C. Krause, Eric P. Skaar, Amanda L. McCoy, Gleb Pishchany, James E. Crowe, Mary E. Fabry, Victor J. Torres
Publikováno v:
Cell Host & Microbe. 8(6):544-550
SummaryIron is required for bacterial proliferation, and Staphylococcus aureus steals this metal from host hemoglobin during invasive infections. This process involves hemoglobin binding to the cell wall of S. aureus, heme extraction, passage through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3af85105cab214de0634cac36ecd71
Autor:
Dinakantha S. Kumararatne, Xavier Bossuyt, Toshiro Hara, Cyrille Hoarau, László Maródi, Nicolas Sirvent, Claudia Fortuny, Capucine Picard, Joseph B. Domachowske, Horst von Bernuth, Maria Méndez, John I. Gallin, Jean-Laurent Casanova, Laia Alsina, Simona Eva Zitnik, Abdulaziz Al-Ghonaium, David P. Speert, Anne Puel, Artur Bonito Vitor, Carlos Rodrigo, Noorbibi K. Day-Good, Juan I. Aróstegui, Chaim M. Roifman, E. Graham Davies, Júlia Vasconcelos, Hidetoshi Takada, Raif S. Geha, Sami Al-Hajjar, C. Buddy Creech, Carlos Rodríguez-Gallego, Mimi L.K. Tang, Douglas R. McDonald, Yildiz Camcioglu, Joanne Smart, Rainer Döffinger, Jens C. Krause, James W. Verbsky, Ofer Levy, Adrian J. Thrasher, Margarida Guedes, Dominique De Ricaud, Helen Chapel, Elena Colino, Andrew C. Issekutz, Steven M. Holland, Claire Bethune, Hideto Yoshikawa, Stephan Ehl, Saleh Al-Muhsen, Ben Zion Garty, Maya Chrabieh, Cheng-Lung Ku, Shigeaki Nonoyama, Janine Reichenbach, Pegah Ghandil, Francisco Almazán, Laurent Abel, Peter D. Arkwright
Publikováno v:
Medicine. 89:403-425
Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid differentiation factor (MyD)88 deficiencies impair Toll-like receptor (TLR)- and interleukin-1 receptor-mediated immunity. We documented the clinical features and outco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7085695ec566c1c02c60d78d2eaac1
https://doi.org/10.1097/md.0b013e3181fd8ec3
https://doi.org/10.1097/md.0b013e3181fd8ec3
Autor:
Rong Hai, Chelsey J. Huffman, Patricia A. McGraw, Terrence M. Tumpey, James E. Crowe, Jens C. Krause, Melissa B. Pearce, Christopher F. Basler, Tshidi Tsibane
Publikováno v:
Journal of Virology. 84:3127-3130
The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de066486c06ef943ceacf43a3a1ad8a3
https://doi.org/10.1128/jvi.02184-09
https://doi.org/10.1128/jvi.02184-09
Autor:
James E. Crowe, Jens C. Krause
Publikováno v:
Microbiology spectrum. 2(5)
The globular head of the trimeric influenza hemagglutinin (HA) contains the receptor-binding domain (RBD) and is the target of potently neutralizing human monoclonal antibodies (mAbs) with high in vivo activity. In general, these mAbs are induced eas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a3261f3c59de0987c18da28637eb4a
https://pubmed.ncbi.nlm.nih.gov/26104373
https://pubmed.ncbi.nlm.nih.gov/26104373
