Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jens C Rekling"'
Autor:
Mareike Albert, Sandra U Schmitz, Susanne M Kooistra, Martina Malatesta, Cristina Morales Torres, Jens C Rekling, Jens V Johansen, Iratxe Abarrategui, Kristian Helin
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003461 (2013)
Embryonic development is tightly regulated by transcription factors and chromatin-associated proteins. H3K4me3 is associated with active transcription and H3K27me3 with gene repression, while the combination of both keeps genes required for developme
Externí odkaz:
https://doaj.org/article/909a14ca09044a9fb1a9835d6d1b3cc2
Publikováno v:
Biochemistry and Biophysics Reports, Vol 31, Iss , Pp 101288- (2022)
Bile acids (BAs) play an important role in the digestion of dietary fats and act as signaling molecules. However, due to their solubilizing properties, high concentrations in the gut may negatively affect gut epithelium and possibly afferent fibers i
Externí odkaz:
https://doaj.org/article/4a568f181e3041f69e30f0b4875db1a8
Autor:
Kristoffer L. Egerod, Natalia Petersen, Pascal N. Timshel, Jens C. Rekling, Yibing Wang, Qinghua Liu, Thue W. Schwartz, Laurent Gautron
Publikováno v:
Molecular Metabolism, Vol 12, Iss , Pp 62-75 (2018)
Objectives: G protein-coupled receptors (GPCRs) act as transmembrane molecular sensors of neurotransmitters, hormones, nutrients, and metabolites. Because unmyelinated vagal afferents richly innervate the gastrointestinal mucosa, gut-derived molecule
Externí odkaz:
https://doaj.org/article/481cf6923ace4e2c87c2b80e1d6901c5
Publikováno v:
J Neurosci
The inspiratory rhythm generator, located in the brainstem preBötzinger complex (preBötC), is dependent on glutamatergic signaling and is affected profoundly by opioids. Here, we used organotypic slice cultures of the newborn mouse brainstem of eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f72db2fd12f0d390f4ccee8a940b6c8
https://doi.org/10.1523/jneurosci.1369-22.2022
https://doi.org/10.1523/jneurosci.1369-22.2022
Publikováno v:
Neuropeptides. 94
Thyrotropin-releasing hormone (TRH) plays a central role in metabolic homeostasis, and single-cell sequencing has recently demonstrated that vagal sensory neurons in the nodose ganglion express thyrotropin-releasing hormone receptor 1 (TRHR1). Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5307c63a4107193c2c19c0c95c0efbf9
https://pubmed.ncbi.nlm.nih.gov/35704969
https://pubmed.ncbi.nlm.nih.gov/35704969
Autor:
Angela R Blissett, Yangyang Wang, Jens C. Rekling, Mustafa Goksel, Talita M. Silva, Thiago S. Moreira, Srinivasan Tupal, Salil Mahajan, Randy J. Nelson, Ning Zhang, Summer Fair, Catherine Czeisler, Michele Joana Alves, Jeremy C. Borniger, Fay Catacutan, Jillian Liu, Ana C. Takakura, Behiye Kaya, Jose Otero, Silvio A. Fernandes‐Junior, Vishnu Sundaresean, Phelipe E. Silva, Aaron Cowgill
Publikováno v:
The Journal of Physiology. 597:2225-2251
KEY POINTS: The embryonic PHOX2B‐progenitor domain generates neuronal and glial cells which together are involved in chemosensory control of breathing and sleep homeostasis. Ablating PHOX2B‐derived astrocytes significantly contributes to secondar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a131faf5bd2c3507b871617b2568953f
https://doi.org/10.1113/jp277082
https://doi.org/10.1113/jp277082
Publikováno v:
eNeuro
GABAergic somatodendritic inhibition in the preBötzinger complex (preBötC), a medullary site for the generation of inspiratory rhythm, is involved in respiratory rhythmogenesis and patterning. Nevertheless, whether GABA acts distally on presynaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00c57482fe378924bb98dd5d58ac3419
https://pubmed.ncbi.nlm.nih.gov/34380658
https://pubmed.ncbi.nlm.nih.gov/34380658
Autor:
Lola Torz, Kristoffer Niss, Sofia Lundh, Jens C. Rekling, Carlos Damian Quintana, Signe Emilie Dannulat Frazier, Aaron J. Mercer, Anda Cornea, Charlotte Vinther Bertelsen, Marina Kjærgaard Gerstenberg, Ann Maria Kruse Hansen, Mette Guldbrandt, Jens Lykkesfeldt, Linu Mary John, J. Carlos Villaescusa, Natalia Petersen
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 3260
Torz, L, Niss, K, Lundh, S, Rekling, J C, Quintana, C D, Frazier, S E D, Mercer, A J, Cornea, A, Bertelsen, C V, Gerstenberg, M K, Hansen, A M K, Guldbrandt, M, Lykkesfeldt, J, John, L M, Villaescusa, J C & Petersen, N 2022, ' NPFF Decreases Activity of Human Arcuate NPY Neurons : A Study in Embryonic-Stem-Cell-Derived Model ', International Journal of Molecular Sciences, vol. 23, no. 6, 3260 . https://doi.org/10.3390/ijms23063260
Torz, L, Niss, K, Lundh, S, Rekling, J C, Quintana, C D, Frazier, S E D, Mercer, A J, Cornea, A, Bertelsen, C V, Gerstenberg, M K, Hansen, A M K, Guldbrandt, M, Lykkesfeldt, J, John, L M, Villaescusa, J C & Petersen, N 2022, ' NPFF Decreases Activity of Human Arcuate NPY Neurons : A Study in Embryonic-Stem-Cell-Derived Model ', International Journal of Molecular Sciences, vol. 23, no. 6, 3260 . https://doi.org/10.3390/ijms23063260
Restoring the control of food intake is the key to obesity management and prevention. The arcuate nucleus (ARC) of the hypothalamus is extensively being studied as a potential anti-obesity target. Animal studies showed that neuropeptide FF (NPFF) red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb1075b5312e468a62bab39485ceb3a
https://doi.org/10.3390/ijms23063260
https://doi.org/10.3390/ijms23063260
Autor:
Laurent Gautron, Jens C. Rekling, Natalia Petersen, Pascal Timshel, Qinghua Liu, Thue W. Schwartz, Yibing Wang, Kristoffer L. Egerod
Publikováno v:
Molecular Metabolism, Vol 12, Iss, Pp 62-75 (2018)
Molecular Metabolism
Egerod, K L, Petersen, N, Timshel, P N, Rekling, J C, Wang, Y, Liu, Q, Schwartz, T W & Gautron, L 2018, ' Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms ', Molecular Metabolism, vol. 12, pp. 62-75 . https://doi.org/10.1016/j.molmet.2018.03.016
Molecular Metabolism
Egerod, K L, Petersen, N, Timshel, P N, Rekling, J C, Wang, Y, Liu, Q, Schwartz, T W & Gautron, L 2018, ' Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms ', Molecular Metabolism, vol. 12, pp. 62-75 . https://doi.org/10.1016/j.molmet.2018.03.016
Objectives G protein-coupled receptors (GPCRs) act as transmembrane molecular sensors of neurotransmitters, hormones, nutrients, and metabolites. Because unmyelinated vagal afferents richly innervate the gastrointestinal mucosa, gut-derived molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6536fbc31c9d41392e1b9d7ebc4d9af9
http://www.sciencedirect.com/science/article/pii/S2212877818302023
http://www.sciencedirect.com/science/article/pii/S2212877818302023
Publikováno v:
Gómez, C D, Rasmussen, C M & Rekling, J C 2021, ' Gabaergic inhibition of presynaptic ca 2+ transients in respiratory prebötzinger neurons in organotypic slice cultures ', eNeuro, vol. 8, no. 4, ENEURO.0154-21.2021 . https://doi.org/10.1523/ENEURO.0154-21.2021
GABAergic somatodendritic inhibition in the preBotzinger Complex (preBotC), a medullary site for the generation of inspiratory rhythm, is involved in respiratory rhythmogenesis and patterning. Nevertheless, whether GABA acts distally on presynaptic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da74f27222aeb7023699464929cba74
https://doi.org/10.1523/eneuro.0154-21.2021
https://doi.org/10.1523/eneuro.0154-21.2021