Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Jens C Brüning"'
Autor:
Christina Ising, Sybille Koehler, Sebastian Brähler, Carsten Merkwirth, Martin Höhne, Olivier R Baris, Henning Hagmann, Martin Kann, Francesca Fabretti, Claudia Dafinger, Wilhelm Bloch, Bernhard Schermer, Andreas Linkermann, Jens C Brüning, Christine E Kurschat, Roman‐Ulrich Müller, Rudolf J Wiesner, Thomas Langer, Thomas Benzing, Paul Thomas Brinkkoetter
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 3, Pp 275-287 (2015)
Abstract Mitochondrial dysfunction and alterations in energy metabolism have been implicated in a variety of human diseases. Mitochondrial fusion is essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit
Externí odkaz:
https://doaj.org/article/aaed36cafd0a43ab8e7e6120f044f0e0
Autor:
Lars Paeger, Andreas Pippow, Simon Hess, Moritz Paehler, Andreas C Klein, Andreas Husch, Christophe Pouzat, Jens C Brüning, Peter Kloppenburg
Publikováno v:
eLife, Vol 6 (2017)
Satiety-signaling, pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the hypothalamus play a pivotal role in the regulation of energy homeostasis. Recent studies reported altered mitochondrial dynamics and decreased mitochondri
Externí odkaz:
https://doaj.org/article/ce7a2701fb6c4ed094bcfdea6a6cbbf4
Autor:
Jan Mauer, Bhagirath Chaurasia, Leona Plum, Thomas Quast, Brigitte Hampel, Matthias Blüher, Waldemar Kolanus, C Ronald Kahn, Jens C Brüning
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000938 (2010)
A major component of obesity-related insulin resistance is the establishment of a chronic inflammatory state with invasion of white adipose tissue by mononuclear cells. This results in the release of pro-inflammatory cytokines, which in turn leads to
Externí odkaz:
https://doaj.org/article/9b011073f41e434fb955e21b43d1c963
Autor:
Kerstin Griess, Michael Rieck, Nadine Müller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jürgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Miriam Cnop, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S. Reichert, Daniel Markgraf, Marianne Wammers, Dieter Häussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Höglinger, Thorsten Hornemann, Jens C. Brüning, Bengt-Frederik Belgardt
Publikováno v:
Nat. Cell Biol. 25, 20–29 (2023)
Impaired proinsulin-to-insulin processing in pancreatic β-cells is a key defective step in both type 1 diabetes and type 2 diabetes (T2D) (refs. 1,2), but the mechanisms involved remain to be defined. Altered metabolism of sphingolipids (SLs) has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2260e154d029f1a9d54ef2017f9e380c
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=67090
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=67090
Autor:
Anna Sieben, F. Thomas Wunderlich, Dong Kong, Xing Xiao, Peter Kloppenburg, André Kleinridders, Thomas E. Scammell, Gagik Yeghiazaryan, Simon Hess, A. Christine Hausen, Paul Klemm, Bradford B. Lowell, Jens C. Brüning, Kamal Rahmouni, Donald A. Morgan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here we show orexin receptor type 1 and 2 are predominantly expressed in dorsal raphe nucleus-dorsal and -ventral, respectively. Serotonergic neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39018121014cacedc640165017f559f8
https://doaj.org/article/526ad1da292b4e9a9a66f3e0635380a6
https://doaj.org/article/526ad1da292b4e9a9a66f3e0635380a6
Autor:
Isabella Gaziano, Svenja Corneliussen, Nasim Biglari, René Neuhaus, Linyan Shen, Tamara Sotelo-Hitschfeld, Paul Klemm, Lukas Steuernagel, Alain J. De Solis, Weiyi Chen, F. Thomas Wunderlich, Peter Kloppenburg, Jens C. Brüning
Publikováno v:
JCI Insight. 7
Dopamine acts on neurons in the arcuate nucleus (ARC) of the hypothalamus, which controls homeostatic feeding responses. Here we demonstrate a differential enrichment of dopamine receptor 1 (Drd1) expression in food intake-promoting agouti related pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095e9a0ef2bda083045293304f137773
https://doi.org/10.1172/jci.insight.162753
https://doi.org/10.1172/jci.insight.162753
Autor:
Anna Juliane Vesting, Alexander Jais, Paul Klemm, Lukas Steuernagel, Peter Wienand, Morten Fog-Tonnesen, Henning Hvid, Anna–Lena Schumacher, Christian Kukat, Hendrik Nolte, Theodoros Georgomanolis, Janine Altmüller, Manolis Pasparakis, Andreas Schmidt, Marcus Krüger, Marc Schmidt Supprian, Ari Waisman, Beate Katharina Straub, Nathanael Raschzok, Michel Bernier, Andreas L. Birkenfeld, Nadine Hövelmeyer, Jens C. Brüning, F. Thomas Wunderlich
Publikováno v:
Mol Metab
Mol. Metab. 66:101626 (2022)
Mol. Metab. 66:101626 (2022)
OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) ranges from steatosis to nonalcoholic steatohepatitis (NASH), which often progresses to hepatocellular carcinoma (HCC) through a largely undefined mechanism. NASH and HCC depend on inflammatory sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bce082ac7f3b02d5f3048fe04b0a9b6
https://hdl.handle.net/21.11116/0000-000B-B68B-B
https://hdl.handle.net/21.11116/0000-000B-B68B-B
Autor:
Jonathan D. Teo, Oana C. Marian, Alanna G. Spiteri, Madeline Nicholson, Huitong Song, Jasmine X. Y. Khor, Holly P. McEwen, Anjie Ge, Monokesh K. Sen, Laura Piccio, Jessica L. Fletcher, Nicholas J. C. King, Simon S. Murray, Jens C. Brüning, Anthony S. Don
Publikováno v:
GliaREFERENCES.
The sphingolipids galactosylceramide (GalCer), sulfatide (ST) and sphingomyelin (SM) are essential for myelin stability and function. GalCer and ST are synthesized mostly from C22-C24 ceramides, generated by Ceramide Synthase 2 (CerS2). To clarify th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd0aa8eae28e42f1e57fd6b417fb276
https://pubmed.ncbi.nlm.nih.gov/36583573
https://pubmed.ncbi.nlm.nih.gov/36583573
Autor:
Carlos G. Ardanaz, Aida de la Cruz, Marcos Elizalde-Horcada, Elena Puerta, María J. Ramírez, Jorge E. Ortega, Ainhoa Urbiola, Cristina Ederra, Mikel Ariz, Carlos Ortiz-de-Solórzano, Joaquín Fernández- Irigoyen, Enrique Santamaría, Gerard Karsenty, Jens C. Brüning, Maite Solas
Astrocytes are considered an essential source of blood-borne glucose or its metabolites to neurons. Nonetheless, the necessity of the main astrocyte glucose transporter, i.e. GLUT1, for brain glucose metabolism has not been defined. Unexpectedly, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e068491e7105c9f1e2f4e581977fa16f
https://doi.org/10.1101/2022.10.06.511112
https://doi.org/10.1101/2022.10.06.511112
Autor:
Philipp Hammerschmidt, Jens C. Brüning
Publikováno v:
Cellular and Molecular Life Sciences. 79
Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play specialized regulatory roles in cellular metabolism depending on their characteristic fatty acyl chain lengths and subcellular distribution. As obesity progresses, cert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c61b4d2d6441cbb907efc22c0736c32e
https://doi.org/10.1007/s00018-022-04401-3
https://doi.org/10.1007/s00018-022-04401-3