Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jens Buchardt"'
Autor:
Yara Huppelschoten, Jens Buchardt, Thomas E. Nielsen, Aysegul Sapmaz, Gerbrand J. van der Heden van Noort
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 884 (2023)
Autophagy is a conserved cellular process involved in the degradation of intercellular materials. During this process, double-membrane vesicles called autophagosomes engulf cytoplasmic components ready for degradation. A key component in the formatio
Externí odkaz:
https://doaj.org/article/b9f4b250732d484681a86fb0ef2bab79
Autor:
Maj Petersen, Prafull S. Gandhi, Jens Buchardt, Tomas Alanentalo, Johannes Josef Fels, Nils Langeland Johansen, Peter Helding-Kvist, Knud Vad, Peter Thygesen
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1181 (2020)
Somapacitan is a long-acting, once-weekly, albumin-binding growth hormone (GH) derivative. The reversible albumin-binding properties leads to prolonged circulation half-life. Here, we investigated and compared somapacitan with human GH on downstream
Externí odkaz:
https://doaj.org/article/b6e20898e3814bc7a7e1b4d981469a96
Autor:
Yara, Huppelschoten, Jens, Buchardt, Thomas Eiland, Nielsen, Gerbrand J, van der Heden van Noort
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2602
Solid-phase peptide synthesis (SPPS) enables the synthesis of chemically modified peptides and proteins. Chemically synthesized ubiquitin(-like) proteins containing a fluorescent tag or reactive warhead have proven to be important tools in elucidatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d548e8f79dcb41b8140aba2df16e79d
https://pubmed.ncbi.nlm.nih.gov/36446966
https://pubmed.ncbi.nlm.nih.gov/36446966
Autor:
Tomas Alanentalo, Nils Langeland Johansen, Jens Buchardt, Knud Vad, Peter Thygesen, Prafull S. Gandhi, Johannes Josef Fels, Maj Petersen, Peter Helding-Kvist
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1181 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 4
International Journal of Molecular Sciences
Volume 21
Issue 4
Somapacitan is a long-acting, once-weekly, albumin-binding growth hormone (GH) derivative. The reversible albumin-binding properties leads to prolonged circulation half-life. Here, we investigated and compared somapacitan with human GH on downstream
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7858fd82c1582eb0b5f986f6b7db2a5f
https://www.mdpi.com/1422-0067/21/4/1181
https://www.mdpi.com/1422-0067/21/4/1181
Autor:
Jens Buchardt, Carsten Behrens
GlycoPEGylation is a site-selective PEGylation method developed for modifying complex glycoproteins. It relies on the ability of glycosyltransferases to efficiently transfer polyethylene glycol (PEG)–modified sugar nucleotides to the glycan termini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21044c419c1f7ed1be3c5a74706b7f01
https://doi.org/10.1016/b978-0-444-64081-9.00012-7
https://doi.org/10.1016/b978-0-444-64081-9.00012-7
Autor:
Amr S. Abu Lila, Rosalía Agusti, Sahar Awwad, Carsten Behrens, Mary J. Bossard, Gunda Brandenburg, Steve Brocchini, Jens Buchardt, Chris Caster, Victor R. de la Rosa, Rosa M. de Lederkremer, Celine Derunes, Nehal E. Elsadek, Elaine L. Ferguson, Marc A. Gauthier, M. Eugenia Giorgi, Kenneth Grabstein, Andrea A. Greschner, Antonella Grigoletto, Richard Hoogenboom, Tatsuhiro Ishida, Waliul Islam, Nandini V. Katre, Hanieh Khalili, Ralf Krähmer, Michael J. LaBarre, Frank Leenders, Gary Li, Kenneth W. Locke, Hiroshi Maeda, Daniel C. Maneval, Katia Maso, Mann Muhsin, Natalie Winblade Nairn, Steffen Nock, Gianfranco Pasut, Christina Picken, Sabine Poppenborg, Christoph Radcke, Sybille Sauter, Ondrej Sedlacek, Rose E. Sekulovich, Kurt D. Shanebeck, Jürgen Siekmann, Joana Stokniene, David W. Thomas, Curtis B. Thompson, Peter L. Turecek, Mathieu Varache, María J. Vicent, Aijun Wang, Julia Wittmann, Ahlem Zaghmi, Samuel Zalipsky, Mire Zloh, Linglong Zou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5499b541259ce8ea55013fa36b35449
https://doi.org/10.1016/b978-0-444-64081-9.01002-0
https://doi.org/10.1016/b978-0-444-64081-9.01002-0
Autor:
Peter Thygesen, Charlotta G. Folkesson, Charlotte Wiberg, Henrik S. Ramírez-Andersen, Mats Reslow, Jens Buchardt, Per Franklin Nielsen, Xin Zhao, Nils Langeland Johansen, Johannes Josef Fels, Chen Jianhe, Leif Nørskov-Lauritsen, Christian Rischel, Xia Wenjuan, Jing Su, Carsten Behrens
Publikováno v:
Bioconjugate Chemistry. 29:3129-3143
The present work describes a series of human growth hormone (hGH) albumin binder conjugates with an extended in vivo half-life. A broad range of different conjugates were studied by varying the albumin binder structure and conjugation site. Conjugate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82348c015bc30de66842f2cd5ec1fd9
https://doi.org/10.1021/acs.bioconjchem.8b00463
https://doi.org/10.1021/acs.bioconjchem.8b00463
Autor:
Jens Buchardt, Heidi L. Holmberg, Johan Karlsson, Mads Kjelgaard-Hansen, Kasper Lamberth, Anders B. Sorensen, Wolfram Ruf, Prafull S. Gandhi, Carsten Dan Ley, Brit B. Sørensen, Anders Lærke Nielsen, Henrik Østergaard, Ole Hvilsted Olsen
Publikováno v:
Proceedings of the National Academy of Sciences. 114:12454-12459
Recombinant factor VIIa (FVIIa) variants with increased activity offer the promise to improve the treatment of bleeding episodes in patients with inhibitor-complicated hemophilia. Here, an approach was adopted to enhance the activity of FVIIa by sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf0681d039e3e21fd96e4f18b164330
https://doi.org/10.1073/pnas.1618713114
https://doi.org/10.1073/pnas.1618713114
Autor:
Donald F. Brophy, Heidi L. Holmberg, Thomas Egebjerg, Helle Demuth, Mari Enoksson, Jens Buchardt, Thomas N. Krogh, Mette S Jensen, Marianne Kjalke, Erika J. Martin, Mads Kjelgaard-Hansen, Ida Hilden, Annika Sanfridson
Publikováno v:
Journal of thrombosis and haemostasis : JTHREFERENCES. 18(1)
Background Recombinant factor VIIa (rFVIIa) enhances thrombin generation in a platelet-dependent manner; however, rFVIIa binds activated platelets with relatively low affinity. Triggering receptor expressed on myeloid cells (TREM)-like transcript (TL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929d68c768514bf13eb8750a838bf875
https://pubmed.ncbi.nlm.nih.gov/31549480
https://pubmed.ncbi.nlm.nih.gov/31549480
Autor:
Jens Buchardt, Stephen B. H. Kent, Paul F. Alewood, Caspar Christensen, Aline Dantas de Araujo
Publikováno v:
Chemistry - A European Journal. 17:13983-13986
In the image: The design and synthesis of peptidomimetics that maintain the configuration of the triad Asp-Thr-Gly found in the catalytic site of the HIV-1 protease (see scheme) are described. By using regioselective nitration and reductive lactamisa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32264547b13613b4b9b44096fcdbac66
https://doi.org/10.1002/chem.201102732
https://doi.org/10.1002/chem.201102732