Výsledky vyhledávání - "Jens Blobner"

Akademický článek

In vivo dynamics and anti-tumor effects of EpCAM-directed CAR T-cells against brain metastases from lung cancer

Publikováno v: OncoImmunology, Vol 12, Iss 1 (2023)

ABSTRACTLung cancer patients are at risk for brain metastases and often succumb to their intracranial disease. Chimeric Antigen Receptor (CAR) T-cells emerged as a powerful cell-based immunotherapy for hematological malignancies; however, it remains

Externí odkaz: https://doaj.org/article/2cd0fd06eccb45e2812b5a5b9cb1aecb

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Akademický článek

AMPLIFY-NEOVAC: a randomized, 3-arm multicenter phase I trial to assess safety, tolerability and immunogenicity of IDH1-vac combined with an immune checkpoint inhibitor targeting programmed death-ligand 1 in isocitrate dehydrogenase 1 mutant gliomas

Autor: Lukas Bunse, Anne-Kathleen Rupp, Isabel Poschke, Theresa Bunse, Katharina Lindner, Antje Wick, Jens Blobner, Martin Misch, Ghazaleh Tabatabai, Martin Glas, Oliver Schnell, Jens Gempt, Monika Denk, Guido Reifenberger, Martin Bendszus, Patrick Wuchter, Joachim P Steinbach, Wolfgang Wick, Michael Platten

Publikováno v: Neurological Research and Practice, Vol 4, Iss 1, Pp 1-7 (2022)

Abstract Introduction Isocitrate dehydrogenase (IDH) mutations are disease-defining mutations in IDH-mutant astrocytomas and IDH-mutant and 1p/19q-codeleted oligodendrogliomas. In more than 80% of these tumors, point mutations in IDH type 1 (IDH1) le

Externí odkaz: https://doaj.org/article/4c9969cb47df44d0813e1eae513b7e2a

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Akademický článek

In vivo two-photon characterization of tumor-associated macrophages and microglia (TAM/M) and CX3CR1 during different steps of brain metastasis formation from lung cancer

Autor: Wenlong Zhang, Philipp Karschnia, Iven-Alex von Mücke-Heim, Matthias Mulazzani, Xiaolan Zhou, Jens Blobner, Niklas Mueller, Nico Teske, Sertac Dede, Tao Xu, Niklas Thon, Hellen Ishikawa-Ankerhold, Andreas Straube, Joerg-Christian Tonn, Louisa von Baumgarten

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 11, Pp 1089-1100 (2021)

Brain metastases frequently occur in lung cancer and dramatically limit prognosis of affected patients. The influence of tumor-associated macrophages and microglia (TAM/M) and their receptor CX3CR1 on different steps of brain metastasis formation fro

Externí odkaz: https://doaj.org/article/13e3e60ed87b47a6a75f2a7c979d630b

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Akademický článek

Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers

Autor: Philipp Karschnia, Jonathan Weller, Jens Blobner, Veit M. Stoecklein, Mario M. Dorostkar, Kai Rejeski, Robert Forbrig, Maximilian Niyazi, Louisa von Baumgarten, Jorg Dietrich, Joerg-Christian Tonn, Niklas Thon

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract Neural stem cells within the subventricular zone were identified as cells of origin driving growth of high-grade gliomas, and anatomical involvement of the subventricular zone has been associated with an inferior clinical outcome. Whether th

Externí odkaz: https://doaj.org/article/4a3f8ed6334e4c18b870dfcb35a3b312

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Akademický článek

18 kDa translocator protein positron emission tomography facilitates early and robust tumor detection in the immunocompetent SB28 glioblastoma mouse model

Publikováno v: Frontiers in Medicine, Vol 9 (2022)

IntroductionThe 18 kDa translocator protein (TSPO) receives growing interest as a biomarker in glioblastoma. Mouse models can serve as an important tool for the investigation of biomarkers in glioblastoma, but several glioblastoma models indicated on

Externí odkaz: https://doaj.org/article/3005aeed99994e34b3cb32a36542ee40

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Akademický článek

Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Modeling patient-individual resistance to immunotherapy is challenging. Here, the authors use a syngeneic experimental hypermutated orthotopic glioma model to define radiological and biological features that can predict or explain the mechanistic dif

Externí odkaz: https://doaj.org/article/65441a7f16a24904a9e706ac1ace56b2

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Shunt dependency in supratentorial intraventricular tumors depends on the extent of tumor resection

Autor: Nico Teske, Mariana Chiquillo-Domínguez, Benjamin Skrap, Patrick N. Harter, Kai Rejeski, Jens Blobner, Louisa von Baumgarten, Joerg-Christian Tonn, Mathias Kunz, Niklas Thon, Philipp Karschnia

Publikováno v: Acta Neurochirurgica. 165:1053-1064

Background Supratentorial intraventricular tumors (SIVTs) are rare lesions of various entities characteristically presenting with hydrocephalus and often posing a surgical challenge due to their deep-seated localization. We aimed to elaborate on shun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3524059e33cc7299687c21c80f2e5662
https://doi.org/10.1007/s00701-023-05532-7

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