Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Jens, Zimmer"'
Publikováno v:
Stem Cells International, Vol 2012 (2012)
The potential use of predifferentiated neural precursor cells for treatment of a neurological disorder like Parkinson’s disease combines stem cell research with previous experimental and clinical transplantation of developing dopaminergic neurons.
Externí odkaz:
https://doaj.org/article/3fdb63e435ab42f7837b8864b04b8c3e
Publikováno v:
Cell Transplantation, Vol 12 (2003)
Several previous studies, suggesting the potential use of embryonic xenografts in the treatment of neurological disorders, indicate that neural growth and axonal guidance factors may function across species. In this light, blocks of fetal porcine neo
Externí odkaz:
https://doaj.org/article/39ba3e25300645968047c96f0f0ca6de
Autor:
Annette Møller Dall, Erik Hvid Danielsen, Jens Christian Sørensen, Flemming Andersen, Arne Møller, Jens Zimmer, Albert H. Gjedde, Paul Cumming
Publikováno v:
Cell Transplantation, Vol 11 (2002)
The functional restoration of the dopamine innervation of striatum in MPTP-poisoned Göttingen minipigs was assessed for 6 months following grafting of fetal pig mesencephalic neurons. Pigs were assigned to a normal control group and a MPTP-poisoned
Externí odkaz:
https://doaj.org/article/0a1a8da06a474ebaaaa4103df5925ed3
Publikováno v:
Cell Transplantation, Vol 10 (2001)
The immunogenicity of porcine tissue is a major obstacle to its use as donor material in xenotransplantation for neurodegenerative diseases. We are currently evaluating a novel strategy for reducing the immunogenicity, in which the α-galactosyl epit
Externí odkaz:
https://doaj.org/article/4a561e19315343e6aa65f1e1a7267262
Publikováno v:
Cell Transplantation, Vol 8 (1999)
Among the dopaminergic neurons in substantia nigra pars compacta and in the ventral tegmental area, subpopulations express the calcium-binding proteins calbindin (CB) and calretinin (CR), and the CB-containing neurons are supposed to be less prone to
Externí odkaz:
https://doaj.org/article/0f9cb6754f7542b2838f5362b3069d4e
Publikováno v:
Cell Transplantation, Vol 6 (1997)
Intracerebral grafting of porcine fetal brain cells is a potential treatment of neurodegenerative disorders in humans. Although it is well known that the survival of fetal pig brain cells in the rat brain requires immunosuppression, the response of h
Externí odkaz:
https://doaj.org/article/205f41c4182b4f05b9608013920b3732
Autor:
Jens, Zimmer Rasmussen
Publikováno v:
Ugeskrift for laeger. 175(36)
Publikováno v:
Jensen, P, Gramsbergen, J-B, Zimmer, J, Widmer, H R & Meyer, M 2011, ' Enhanced proliferation and dopaminergic differentiation of ventral mesencephalic precursor cells by synergistic effect of FGF2 and reduced oxygen tension ', Experimental Cell Research, vol. 317, no. 12, pp. 1649-62 . https://doi.org/10.1016/j.yexcr.2011.04.012
Effective numerical expansion of dopaminergic precursors might overcome the limited availability of transplantable cells in replacement strategies for Parkinson's disease. Here we investigated the effect of fibroblast growth factor-2 (FGF2) and FGF8
Publikováno v:
Neuroscience Letters. 464:203-208
There is a lot of excitement about the potential use of multipotent neural stem cells for the treatment of neurodegenerative diseases. However, the strategy is compromised by the general loss of multipotency and ability to generate neurons after long
Publikováno v:
Montero, M, Gonzàlez, B & Zimmer, J 2009, ' Immunotoxic depletion of microglia in mouse hippocampal slice cultures enhances ischemia-like neurodegeneration ', Experimental Neurology, vol. 129, pp. 140-152 .
Microglial cells have been attributed both neuroprotective and neurodegenerative roles in cerebral ischemia. This study presents an immunotoxic method for depletion of microglia from mouse hippocampal slice cultures and the effect of this on ischemia