Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jens, Nolting"'
Autor:
Savita Bisht, Jens Nolting, Ute Schütte, Jens Haarmann, Prashi Jain, Dhruv Shah, Peter Brossart, Patrick Flaherty, Georg Feldmann
Publikováno v:
Translational Oncology, Vol 8, Iss 4, Pp 295-307 (2015)
Despite considerable progress in recent years, the overall prognosis of metastatic malignant melanoma remains poor, and curative therapeutic options are lacking. Therefore, better understanding of molecular mechanisms underlying melanoma progression
Externí odkaz:
https://doaj.org/article/8c4188bbd7ef4f0ba949e7acfb9e85c5
Publikováno v:
Cancer Immunology, Immunotherapy. 70:107-121
Bromo- and extra-terminal domain (BET) inhibitors represent potential therapeutic approaches in solid and hematological malignancies that are currently analyzed in several clinical trials. Additionally, BET are involved in the epigenetic regulation o
Autor:
Daniel, Hofbauer, Dimitrios, Mougiakakos, Luca, Broggini, Mario, Zaiss, Maike, Büttner-Herold, Christian, Bach, Bernd, Spriewald, Frank, Neumann, Savita, Bisht, Jens, Nolting, Robert, Zeiser, Shaima'a, Hamarsheh, Martin, Eberhardt, Julio, Vera, Cristina, Visentin, Chiara Maria Giulia, De Luca, Fabio, Moda, Stefan, Haskamp, Cindy, Flamann, Martin, Böttcher, Katrin, Bitterer, Simon, Völkl, Andreas, Mackensen, Stefano, Ricagno, Heiko, Bruns
Publikováno v:
Immunity. 54(8)
As substantial constituents of the multiple myeloma (MM) microenvironment, pro-inflammatory macrophages have emerged as key promoters of disease progression, bone destruction, and immune impairment. We identify beta-2-microglobulin (β2m) as a driver
Autor:
Savita Bisht, Stefano Ricagno, Heiko Bruns, Mario M. Zaiss, Shaima’a Hamarsheh, Andreas Mackensen, Christian Bach, Martin Eberhardt, Dimitrios Mougiakakos, Luca Broggini, Simon Völkl, Martin Böttcher, Jens Nolting, Daniel Hofbauer, Maike Büttner-Herold, Fabio Moda, Chiara De Luca, Katrin Bitterer, Robert Zeiser, Julio Vera, Frank Neumann
Publikováno v:
SSRN Electronic Journal.
As significant constituents of the tumor microenvironment in multiple Myeloma (MM), pro-inflammatory macrophages are key promoters of disease progression, bone destruction, and immune-impairment. Consequently, the identification of endogenous mediato
Autor:
Heiko Bruns, Stefano Ricagno, Cindy Flamann, Shaima’a Hamarsheh, Frank Neumann, Andreas Mackensen, Katrin Bitterer, Maike Büttner-Herold, Cristina Visentin, Robert Zeiser, Christian Bach, Dimitrios Mougiakakos, Stefan Haskamp, Daniel Hofbauer, Martin Böttcher, Savita Bisht, Chiara De Luca, Fabio Moda, Martin Eberhardt, Luca Broggini, Bernd M. Spriewald, Julio Vera, Mario M. Zaiss, Jens Nolting, Simon Völkl
Publikováno v:
Immunity. 54:1772-1787.e9
As substantial constituents of the multiple myeloma (MM) microenvironment, pro-inflammatory macrophages have emerged as key promoters of disease progression, bone destruction, and immune impairment. We identify beta-2-microglobulin (β2m) as a driver
Publikováno v:
Journal of Oncology, Vol 2019 (2019)
Journal of Oncology
Journal of Oncology
Therapeutic options for advanced stage cholangiocellular carcinoma (CCC) are very limited as of today and patients carry an exceptionally poor overall prognosis. In recent years, increasing evidence has been accumulated to suggest that malignant cell
Autor:
Daniel Hofbauer, Savita Bisht, Robert Zeiser, Jens Nolting, Heiko Bruns, Shaima’a Hamarsheh, Dimitrios Mougiakakos, Andreas Mackensen, Frank Neumann, Stefano Ricagno, Maike Büttner-Herold, Katrin Bitterer, Martin Boettcher, Martin Eberhardt, Mario M. Zaiss
Publikováno v:
Blood. 134:2314-2314
Multiple myeloma (MM) is closely dependent on cross-talk between malignant plasma cells and cellular components of the inflammatory bone marrow milieu, which promotes disease progression, bone destruction and immune-impairment. However, the molecular
Autor:
Simon Jitschin, Heiko Bruns, Leonhard Busch, Jens Nolting, Deniz Gezer, Rainer Boxhammer, Diana Dudziak, Bernd M. Spriewald, Christian P. Pallasch, Friedrich F. Hennig, Maike Büttner-Herold, Jörg Thomas Bittenbring, Dietrich A. Volmer, Frank Neumann, Andreas Mackensen, Markus H. Hoffmann, Christian Bach, Miriam J. Müller, Savita Bisht, Dimitrios Mougiakakos, Martin Böttcher, Heidi Balzer, Kolja Gelse, Mario Fabri, Fabian Beier
Publikováno v:
Leukemia. 32(11)
Macrophages are key mediators of the therapeutic effects exerted by monoclonal antibodies, such as the anti-CD38 antibody MOR202, currently introduced in multiple myeloma (MM) therapy. Therefore, it is important to understand how antibody-mediated ef
Autor:
Jens Haarmann, Georg Feldmann, Ute Schütte, Jens Nolting, Dhruv Shah, Savita Bisht, Prashi Jain, Peter Brossart, Patrick T. Flaherty
Publikováno v:
Translational Oncology, Vol 8, Iss 4, Pp 295-307 (2015)
Translational Oncology
Translational Oncology
Despite considerable progress in recent years, the overall prognosis of metastatic malignant melanoma remains poor, and curative therapeutic options are lacking. Therefore, better understanding of molecular mechanisms underlying melanoma progression
Autor:
JĂśrg Wenzel, Alexander Rupp, Georg Feldmann, Peter Brossart, Stefan Holdenrieder, Rolf Schubert, Gerd Bendas, Jens Nolting, Martin Schlesinger, Savita Bisht
Publikováno v:
Journal of Nanobiotechnology
Background Pancreatic cancer is one of the most lethal of human malignancies known to date and shows relative insensitivity towards most of the clinically available therapy regimens. 3,5-bis(2-fluorobenzylidene)-4-piperidone (EF24), a novel synthetic