Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Jens, Klockgether"'
Autor:
Leif Tueffers, Aditi Batra, Johannes Zimmermann, João Botelho, Florian Buchholz, Junqi Liao, Nicolás Mendoza Mejía, Antje Munder, Jens Klockgether, Burkhard Tüemmler, Jan Rupp, Hinrich Schulenburg
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 7 (2024)
ABSTRACT Pseudomonas aeruginosa is a ubiquitous, opportunistic human pathogen. Since it often expresses multidrug resistance, new treatment options are urgently required. Such new treatments are usually assessed with one of the canonical laboratory s
Externí odkaz:
https://doaj.org/article/03e4de67c9534611a14e37d744063dcb
Autor:
Lutz Wiehlmann, Jens Klockgether, Anna-Silke Hammerbacher, Prabhakar Salunkhe, Sonja Horatzek, Antje Munder, Janno Florian Peilert, Erich Gulbins, Leo Eberl, Burkhard Tümmler
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Pseudomonas aeruginosa TBCF10839 is a highly virulent strain that can persist and replicate in human neutrophils. Screening of a signature-tagged mutagenesis (STM) TBCF10839 transposon library in phagocytosis tests identified a mutant that carried th
Externí odkaz:
https://doaj.org/article/0b7f0c8fd7c94245b93a15847d6c7fe8
Autor:
João Botelho, Leif Tüffers, Janina Fuss, Florian Buchholz, Christian Utpatel, Jens Klockgether, Stefan Niemann, Burkhard Tümmler, Hinrich Schulenburg
Publikováno v:
EBioMedicine, Vol 90, Iss , Pp 104532- (2023)
Summary: Background: Pseudomonas aeruginosa is an opportunistic pathogen consisting of three phylogroups (hereafter named A, B, and C). Here, we assessed phylogroup-specific evolutionary dynamics across available and also new P. aeruginosa genomes. M
Externí odkaz:
https://doaj.org/article/4ede90c0a17f41b98e9f91e82f30bd84
Autor:
Jens Klockgether, Marie-Madlen Pust, Colin F. Davenport, Boyke Bunk, Cathrin Spröer, Jörg Overmann, Burkhard Tümmler
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Plasticity of Pseudomonas aeruginosa chromosomes is mainly driven by an extended accessory genome that is shaped by insertion and deletion events. Further modification of the genome composition can be induced by chromosomal inversion events which lea
Externí odkaz:
https://doaj.org/article/424b98a1235647309bc98c06ca5fc248
Publikováno v:
mSystems, Vol 5, Iss 6 (2020)
ABSTRACT Genotyping of 2,882 Pseudomonas aeruginosa isolates that had been collected during the last 40 years identified the ExoU-positive lineages PA14 (ST253) and ST235 as the second and third most frequent clones in the P. aeruginosa population. B
Externí odkaz:
https://doaj.org/article/bace576ba406463b94c76f44d7e48296
Autor:
Katarzyna Pienkowska, Marie-Madlen Pust, Margaux Gessner, Svenja Gaedcke, Ajith Thavarasa, Ilona Rosenboom, Patricia Morán Losada, Rebecca Minso, Christin Arnold, Silke Hedtfeld, Marie Dorda, Lutz Wiehlmann, Jochen G. Mainz, Jens Klockgether, Burkhard Tümmler
Publikováno v:
Microbiology Spectrum. 11
Cystic fibrosis (CF) is the most common life-limiting monogenetic disease in European populations and is caused by mutations in the CFTR gene. Chronic airway infections with opportunistic pathogens are the major morbidity that determines prognosis an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3881ae6ef3f96a70b39eb1e6474790d
https://doi.org/10.1128/spectrum.03633-22
https://doi.org/10.1128/spectrum.03633-22
Autor:
Antje Munder, Justin Rothschuh, Bastian Schirmer, Jens Klockgether, Volkhard Kaever, Burkhard Tümmler, Roland Seifert, Christina Kloth
Publikováno v:
Open Biology, Vol 8, Iss 1 (2018)
The nucleotidyl cyclase ExoY is an effector protein of the type III secretion system of Pseudomonas aeruginosa. We compared the cyclic nucleotide production and lung disease phenotypes caused by the ExoY-overexpressing strain PA103ΔexoUexoT::Tc pUCP
Externí odkaz:
https://doaj.org/article/89467645a4ac471b82c16adc4769651a
Publikováno v:
Current Opinion in Immunology. 83:102328
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac5b4b2b139db9e165f89a1cecee9b44
https://doi.org/10.1016/j.coi.2023.102328
https://doi.org/10.1016/j.coi.2023.102328
Autor:
Jens Klockgether, Burkhard Tümmler
Publikováno v:
F1000Research, Vol 6 (2017)
The versatile and ubiquitous Pseudomonas aeruginosa is an opportunistic pathogen causing acute and chronic infections in predisposed human subjects. Here we review recent progress in understanding P. aeruginosa population biology and virulence, its c
Externí odkaz:
https://doaj.org/article/ecc51c2f2b96444aad677480aa04f4cf
Autor:
João Botelho, Leif Tüffers, Janina Fuss, Florian Buchholz, Christian Utpatel, Jens Klockgether, Stefan Niemann, Burkhard Tümmler, Hinrich Schulenburg
SummaryBackgroundPseudomonas aeruginosais an opportunistic pathogen consisting of three phylogroups (hereafter named A, B, and C) of unevenly distributed size. Here, we assessed phylogroup-specific evolutionary dynamics in a collection ofP. aeruginos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef32f3b7af482a34caac887d9d91760b
https://doi.org/10.1101/2022.04.24.489302
https://doi.org/10.1101/2022.04.24.489302
